School of Medicine
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Manish J. Butte, MD PhD
Assistant Professor of Pediatrics (Immunology)
Current Research and Scholarly Interests Our laboratory's goal is to address fundamental and therapeutic questions in immunology using innovative nanotechnological and biophysical approaches to visualize and manipulate cells. Our primary focus is on understanding the molecular controls that balance T cell activation versus tolerance. The ultimate aim of our work is to manipulate T cell signaling pathways to control immunologically-mediated diseases.
Professor (Research) of Pediatrics, Emerita
Current Research and Scholarly Interests Our group uses molecular biology, biochemistry, and cellular immunology to investigate the activation and effector function of T lymphocytes. Research in the laboratory is currently focused on three areas: granulysin, a lytic molecule expressed late (7-12 days) after T cell activation; identification of correlates of immunity in diseases such as tuberculosis; and tolerance. The long term goal of this work is to develop new ways to treat human disease.
David K. Hong
Instructor, Pediatrics - Immunology and Allergy
Current Research and Scholarly Interests We are interested in developing new therapeutics and vaccines for respiratory viruses such as Influenza and Respiratory Syncytial Virus. We are particularly interested in studying the immune response in children to these viruses and how these responses could be boosted or shaped using novel vaccine adjuvants
David B. Lewis
Professor of Pediatrics (Immunology) at the Lucile Salter Packard Children's Hospital
Current Research and Scholarly Interests My laboratory has two major research interests. First, to define cellular and molecular mechanisms that limit T cell responses to vaccines and pathogens during normal early postnatal development and in cases of inherited genetic immunodeficiencies. Second, to determine how these limitations in immunity can be overcome by using novel approaches for vaccine adjuvants, with a particular focus on anti-viral vaccines.
Clinical Assistant Professor, Pediatrics - Immunology and Allergy
Current Research and Scholarly Interests Bioinformatics
Kari Nadeau, MD, PhD
Associate Professor of Pediatrics (Allergy & Clinical Immunology) and, by courtesy, of Otolaryngology - Head and Neck Surgery at LPCH
Current Research and Scholarly Interests Kari Nadeau, MD, PhD, Allergy, Immunology and Asthma
Our research interests in the laboratory focus on the role of human T cells, specifically natural regulatory T cells (Treg, in immunological diseases. We aim to differentiate the mechanisms of action of regulatory T cell suppressive function. We study how pollution, such as diesel exhause, disrupt Treg suppressive function and how chemokines, like lymphotactin, enhance Treg suppressive function. We also study Treg function in tolerance.