Bio

Clinical Focus


  • Pediatric Cardiology
  • Pediatric Cardiomyopathy, Heart Failure, and Heart Transplantation

Academic Appointments


Administrative Appointments


  • Director, Cardiomyopathy Program, Stanford University, School of Medicine (2013 - Present)

Boards, Advisory Committees, Professional Organizations


  • Review Board Member, United Network for Organ Sharing (2007 - 2011)
  • Vice Chair, Pediatric Council, International Society of Heart and Lung Transplantation (2010 - 2010)
  • Chair, Pediatric Council, International Society of Heart and Lung Transplantation (2011 - 2012)

Professional Education


  • Medical Education:Weill Medical College Cornell University (1996) NY
  • Board Certification: Pediatric Cardiology, American Board of Pediatrics (2004)
  • Fellowship:Columbia University/New York Presbyterian Hospital (2004) NY
  • Board Certification: Pediatrics, American Board of Pediatrics (1999)
  • Residency:John Hopkins University School of Medicine (1999) MD

Publications

Journal Articles


  • Hot Topics in Tetralogy of Fallot JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY Villafane, J., Feinstein, J. A., Jenkins, K. J., Vincent, R. N., Walsh, E. P., Dubin, A. M., Geva, T., Towbin, J. A., Cohen, M. S., Fraser, C., Dearani, J., Rosenthal, D., Kaufman, B., Graham, T. P. 2013; 62 (23): 2155-2166

    Abstract

    Tetralogy of Fallot (TOF) is the most common cyanotic congenital heart defect. We explore "hot topics" to highlight areas of emerging science for clinicians and scientists in moving toward a better understanding of the long-term management of patients with repaired TOF. From a genetic perspective, the etiology of TOF is multifactorial, with a familial recurrence risk of 3%. Cardiac magnetic resonance is the gold standard assessment tool based on its superior imaging of the right ventricular (RV) outflow tract, pulmonary arteries, aorta, and aortopulmonary collaterals, and on its ability to quantify biventricular size and function, pulmonary regurgitation (PR), and myocardial viability. Atrial re-entrant tachycardia will develop in more than 30% of patients, and high-grade ventricular arrhythmias will be seen in about 10% of patients. The overall incidence of sudden cardiac death is estimated at 0.2%/yr. Risk stratification, even with electrophysiologic testing and cardiac magnetic resonance, remains imperfect. Drug therapy has largely been abandoned, and defibrillator placement, despite its high risks for complications and inappropriate discharges, is often recommended for patients at higher risk. Definitive information about optimal surgical strategies for primary repair to preserve RV function, reduce arrhythmia, and optimize functional status is lacking. Post-operative lesions are often amenable to transcatheter intervention. In selected cases, PR may be treated with transcatheter valve insertion. Ongoing surveillance of RV function is a crucial component of clinical assessment. Except for resynchronization with biventricular pacing, no medical therapies have been shown to be effective after RV dysfunction occurs. In patients with significant PR with RV dilation, optimal timing of pulmonary valve replacement remains uncertain, although accepted criteria are emerging.

    View details for DOI 10.1016/j.jacc.2013.07.100

    View details for Web of Science ID 000328073000002

    View details for PubMedID 24076489

  • Adult and pediatric perspectives on heart retransplant. World journal for pediatric & congenital heart surgery Kaufman, B. D., Jessup, M. 2013; 4 (1): 75-79

    Abstract

    At the Ethics of the Heart II: Ethical and Policy Challenges in Congenital Heart Disease Conference, March 16-17, 2012 in Philadelphia, Pennsylvania, one of the sessions focused on the issues related to end-stage heart failure in patients with congenital heart disease including utilizing the therapy of heart transplantation. This article will summarize the session related to repeat heart transplant that was based on discussion of actual patient cases, two adults and one pediatric, presented, respectively, by an adult and a pediatric heart transplant specialist. Outcome data related to retransplant for both adult and pediatric heart transplant populations are reviewed. The complicated ethical issues related to considerations of beneficence versus nonmalfeasance by a medical care team for an individual patient, patient autonomy related to adherence, and obligations to society to fairly allocate the scarce precious resource of donor organs are discussed.

    View details for DOI 10.1177/2150135112469972

    View details for PubMedID 23799759

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