Bio

Academic Appointments


Honors & Awards


  • Principal Investigator, NIH STTR Grant 1R41EB014605-01A1 (2012-2013)
  • Co-Principal Investigator, UC Discovery Grant # IT107-10166a - Competative Renewal (2011-2012)
  • ASTRO Recognition Award, American Society for Radiation Oncology, Resident Recognition Award in Radiation Physics (2011)
  • Co-Principal Investigator, UC Discovery Grant # IT107-10166 (2008-2011)
  • Norm Baily Award, American Association of Medical Physicists SCC (2009)
  • Mentorship Fellowship, University of California, Los Angeles (2007-2008)
  • Leo P. Delsasso Fellowship, Department of Physics and Astronomy, UCLA (2005-2006)

Professional Education


  • Board Certification, Diplomate of the American Board of Radiology, Therapeutic Medical Physics (2013)
  • Residency, Stanford University, Therapeutic Medical Physics (CAMPEP Accredited) (2012)
  • Ph.D., University of California, Los Angeles, Biomedical Physics (CAMPEP Accredited) (2010)

Research & Scholarship

Current Research and Scholarly Interests


Image Guided Radiotherapy
Stereotactic Radiosurgery
High Dose Rate Brachytherapy

Publications

Journal Articles


  • Seeing the invisible: Direct visualization of therapeutic radiation beams using air scintillation MEDICAL PHYSICS Fahimian, B., Ceballos, A., Tuerkcan, S., Kapp, D. S., Pratx, G. 2014; 41 (1)

    Abstract

    Purpose: To assess whether air scintillation produced during standard radiation treatments can be visualized and used to monitor a beam in a nonperturbing manner.Methods: Air scintillation is caused by the excitation of nitrogen gas by ionizing radiation. This weak emission occurs predominantly in the 300-430 nm range. An electron-multiplication charge-coupled device camera, outfitted with an f∕0.95 lens, was used to capture air scintillation produced by kilovoltage photon beams and megavoltage electron beams used in radiation therapy. The treatment rooms were prepared to block background light and a short-pass filter was utilized to block light above 440 nm.Results: Air scintillation from an orthovoltage unit (50 kVp, 30 mA) was visualized with a relatively short exposure time (10 s) and showed an inverse falloff (r(2) = 0.89). Electron beams were also imaged. For a fixed exposure time (100 s), air scintillation was proportional to dose rate (r(2) = 0.9998). As energy increased, the divergence of the electron beam decreased and the penumbra improved. By irradiating a transparent phantom, the authors also showed that Cherenkov luminescence did not interfere with the detection of air scintillation. In a final illustration of the capabilities of this new technique, the authors visualized air scintillation produced during a total skin irradiation treatment.Conclusions: Air scintillation can be measured to monitor a radiation beam in an inexpensive and nonperturbing manner. This physical phenomenon could be useful for dosimetry of therapeutic radiation beams or for online detection of gross errors during fractionated treatments.

    View details for DOI 10.1118/1.4851595

    View details for Web of Science ID 000329182200004

    View details for PubMedID 24387491

  • Trajectory modulated prone breast irradiation: A LINAC-based technique combining intensity modulated delivery and motion of the couch RADIOTHERAPY AND ONCOLOGY Fahimian, B., Yu, V., Horst, K., Xing, L., Hristov, D. 2013; 109 (3): 475-481

    Abstract

    External beam radiation therapy (EBRT) provides a non-invasive treatment alternative for accelerated partial breast irradiation (APBI), however, limitations in achievable dose conformity of current EBRT techniques have been correlated to reported toxicity. To enhance the conformity of EBRT APBI, a technique for conventional LINACs is developed, which through combined motion of the couch, intensity modulated delivery, and a prone breast setup, enables wide-angular coronal arc irradiation of the ipsilateral breast without irradiating through the thorax and contralateral breast.A couch trajectory optimization technique was developed to determine the trajectories that concurrently avoid collision with the LINAC and maintain the target within the MLC apertures. Inverse treatment planning was performed along the derived trajectory. The technique was experimentally implemented by programming the Varian TrueBeam™ STx in Developer Mode. The dosimetric accuracy of the delivery was evaluated by ion chamber and film measurements in phantom.The resulting optimized trajectory was shown to be necessarily non-isocentric, and contain both translation and rotations of the couch. Film measurements resulted in 93% of the points in the measured two-dimensional dose maps passing the 3%/3mm Gamma criterion. Preliminary treatment plan comparison to 5-field 3D-conformal, IMRT, and VMAT demonstrated enhancement in conformity, and reduction of the normal tissue V50% and V100% parameters that have been correlated with EBRT toxicity.The feasibility of wide-angular intensity modulated partial breast irradiation using motion of the couch has been demonstrated experimentally on a standard LINAC for the first time. For patients eligible for a prone setup, the technique may enable improvement of dose conformity and associated dose-volume parameters correlated with toxicity.

    View details for DOI 10.1016/j.radonc.2013.10.031

    View details for Web of Science ID 000329482000027

    View details for PubMedID 24231240

  • Radiation dose reduction in medical x-ray CT via Fourier-based iterative reconstruction MEDICAL PHYSICS Fahimian, B. P., Zhao, Y., Huang, Z., Fung, R., Mao, Y., Zhu, C., Khatonabadi, M., DeMarco, J. J., Osher, S. J., McNitt-Gray, M. F., Miao, J. 2013; 40 (3)

    Abstract

    A Fourier-based iterative reconstruction technique, termed Equally Sloped Tomography (EST), is developed in conjunction with advanced mathematical regularization to investigate radiation dose reduction in x-ray CT. The method is experimentally implemented on fan-beam CT and evaluated as a function of imaging dose on a series of image quality phantoms and anonymous pediatric patient data sets. Numerical simulation experiments are also performed to explore the extension of EST to helical cone-beam geometry.EST is a Fourier based iterative algorithm, which iterates back and forth between real and Fourier space utilizing the algebraically exact pseudopolar fast Fourier transform (PPFFT). In each iteration, physical constraints and mathematical regularization are applied in real space, while the measured data are enforced in Fourier space. The algorithm is automatically terminated when a proposed termination criterion is met. Experimentally, fan-beam projections were acquired by the Siemens z-flying focal spot technology, and subsequently interleaved and rebinned to a pseudopolar grid. Image quality phantoms were scanned at systematically varied mAs settings, reconstructed by EST and conventional reconstruction methods such as filtered back projection (FBP), and quantified using metrics including resolution, signal-to-noise ratios (SNRs), and contrast-to-noise ratios (CNRs). Pediatric data sets were reconstructed at their original acquisition settings and additionally simulated to lower dose settings for comparison and evaluation of the potential for radiation dose reduction. Numerical experiments were conducted to quantify EST and other iterative methods in terms of image quality and computation time. The extension of EST to helical cone-beam CT was implemented by using the advanced single-slice rebinning (ASSR) method.Based on the phantom and pediatric patient fan-beam CT data, it is demonstrated that EST reconstructions with the lowest scanner flux setting of 39 mAs produce comparable image quality, resolution, and contrast relative to FBP with the 140 mAs flux setting. Compared to the algebraic reconstruction technique and the expectation maximization statistical reconstruction algorithm, a significant reduction in computation time is achieved with EST. Finally, numerical experiments on helical cone-beam CT data suggest that the combination of EST and ASSR produces reconstructions with higher image quality and lower noise than the Feldkamp Davis and Kress (FDK) method and the conventional ASSR approach.A Fourier-based iterative method has been applied to the reconstruction of fan-bean CT data with reduced x-ray fluence. This method incorporates advantageous features in both real and Fourier space iterative schemes: using a fast and algebraically exact method to calculate forward projection, enforcing the measured data in Fourier space, and applying physical constraints and flexible regularization in real space. Our results suggest that EST can be utilized for radiation dose reduction in x-ray CT via the readily implementable technique of lowering mAs settings. Numerical experiments further indicate that EST requires less computation time than several other iterative algorithms and can, in principle, be extended to helical cone-beam geometry in combination with the ASSR method.

    View details for DOI 10.1118/1.4791644

    View details for Web of Science ID 000316369400037

    View details for PubMedID 23464329

  • Single-scan patient-specific scatter correction in computed tomography using peripheral detection of scatter and compressed sensing scatter retrieval MEDICAL PHYSICS Meng, B., Lee, H., Xing, L., Fahimian, B. P. 2013; 40 (1)

    Abstract

    X-ray scatter results in a significant degradation of image quality in computed tomography (CT), representing a major limitation in cone-beam CT (CBCT) and large field-of-view diagnostic scanners. In this work, a novel scatter estimation and correction technique is proposed that utilizes peripheral detection of scatter during the patient scan to simultaneously acquire image and patient-specific scatter information in a single scan, and in conjunction with a proposed compressed sensing scatter recovery technique to reconstruct and correct for the patient-specific scatter in the projection space.The method consists of the detection of patient scatter at the edges of the field of view (FOV) followed by measurement based compressed sensing recovery of the scatter through-out the projection space. In the prototype implementation, the kV x-ray source of the Varian TrueBeam OBI system was blocked at the edges of the projection FOV, and the image detector in the corresponding blocked region was used for scatter detection. The design enables image data acquisition of the projection data on the unblocked central region of and scatter data at the blocked boundary regions. For the initial scatter estimation on the central FOV, a prior consisting of a hybrid scatter model that combines the scatter interpolation method and scatter convolution model is estimated using the acquired scatter distribution on boundary region. With the hybrid scatter estimation model, compressed sensing optimization is performed to generate the scatter map by penalizing the L1 norm of the discrete cosine transform of scatter signal. The estimated scatter is subtracted from the projection data by soft-tuning, and the scatter-corrected CBCT volume is obtained by the conventional Feldkamp-Davis-Kress algorithm. Experimental studies using image quality and anthropomorphic phantoms on a Varian TrueBeam system were carried out to evaluate the performance of the proposed scheme.The scatter shading artifacts were markedly suppressed in the reconstructed images using the proposed method. On the Catphan©504 phantom, the proposed method reduced the error of CT number to 13 Hounsfield units, 10% of that without scatter correction, and increased the image contrast by a factor of 2 in high-contrast regions. On the anthropomorphic phantom, the spatial nonuniformity decreased from 10.8% to 6.8% after correction.A novel scatter correction method, enabling unobstructed acquisition of the high frequency image data and concurrent detection of the patient-specific low frequency scatter data at the edges of the FOV, is proposed and validated in this work. Relative to blocker based techniques, rather than obstructing the central portion of the FOV which degrades and limits the image reconstruction, compressed sensing is used to solve for the scatter from detection of scatter at the periphery of the FOV, enabling for the highest quality reconstruction in the central region and robust patient-specific scatter correction.

    View details for DOI 10.1118/1.4769421

    View details for Web of Science ID 000313033200032

    View details for PubMedID 23298098

  • Scatter correction in cone-beam CT via a half beam blocker technique allowing simultaneous acquisition of scatter and image information MEDICAL PHYSICS Lee, H., Xing, L., Lee, R., Fahimian, B. P. 2012; 39 (5): 2386-2395

    Abstract

    X-ray scatter incurred to detectors degrades the quality of cone-beam computed tomography (CBCT) and represents a problem in volumetric image guided and adaptive radiation therapy. Several methods using a beam blocker for the estimation and subtraction of scatter have been proposed. However, due to missing information resulting from the obstruction of the blocker, such methods require dual scanning or dynamically moving blocker to obtain a complete volumetric image. Here, we propose a half beam blocker-based approach, in conjunction with a total variation (TV) regularized Feldkamp-Davis-Kress (FDK) algorithm, to correct scatter-induced artifacts by simultaneously acquiring image and scatter information from a single-rotation CBCT scan.A half beam blocker, comprising lead strips, is used to simultaneously acquire image data on one side of the projection data and scatter data on the other half side. One-dimensional cubic B-Spline interpolation/extrapolation is applied to derive patient specific scatter information by using the scatter distributions on strips. The estimated scatter is subtracted from the projection image acquired at the opposite view. With scatter-corrected projections where this subtraction is completed, the FDK algorithm based on a cosine weighting function is performed to reconstruct CBCT volume. To suppress the noise in the reconstructed CBCT images produced by geometric errors between two opposed projections and interpolated scatter information, total variation regularization is applied by a minimization using a steepest gradient descent optimization method. The experimental studies using Catphan504 and anthropomorphic phantoms were carried out to evaluate the performance of the proposed scheme.The scatter-induced shading artifacts were markedly suppressed in CBCT using the proposed scheme. Compared with CBCT without a blocker, the nonuniformity value was reduced from 39.3% to 3.1%. The root mean square error relative to values inside the regions of interest selected from a benchmark scatter free image was reduced from 50 to 11.3. The TV regularization also led to a better contrast-to-noise ratio.An asymmetric half beam blocker-based FDK acquisition and reconstruction technique has been established. The proposed scheme enables simultaneous detection of patient specific scatter and complete volumetric CBCT reconstruction without additional requirements such as prior images, dual scans, or moving strips.

    View details for DOI 10.1118/1.3691901

    View details for Web of Science ID 000303604300008

    View details for PubMedID 22559608

  • Low-dose x-ray phase-contrast and absorption CT using equally sloped tomography PHYSICS IN MEDICINE AND BIOLOGY Fahimian, B. P., Mao, Y., Cloetens, P., Miao, J. 2010; 55 (18): 5383-5400

    Abstract

    Tomographic reconstruction from undersampled and noisy projections is often desirable in transmission CT modalities for purposes of low-dose tomography and fast acquisition imaging. However under such conditions, due to the violation of the Nyquist sampling criteria and the presence of noise, reconstructions with acceptable accuracy may not be possible. Recent experiments in transmission electron tomography and coherent diffraction microscopy have shown that the technique of equally sloped tomography (EST), an exact tomographic method utilizing an oversampling iterative Fourier-based reconstruction, provides more accurate image reconstructions when the number of projections is significantly undersampled relative to filtered back projection and algebraic iterative methods. Here we extend this technique by developing new reconstruction algorithms which allow for the incorporation of advanced mathematical regularization constraints, such as the nonlocal means total variational model, in a manner that is consistent with experimental projections. We then evaluate the resulting image quality of the developed algorithm through simulations and experiments at the European Synchrotron Radiation Facility on image quality phantoms using the x-ray absorption and phase contrast CT modalities. Both our simulation and experimental results have indicated that the method can reduce the number of projections by 60-75% in parallel beam modalities, while achieving comparable or better image quality than the conventional reconstructions. As large-scale and compact synchrotron radiation facilities are currently under rapid development worldwide, the implementation of low-dose x-ray absorption and phase-contrast CT can find broad applications in biology and medicine using these advanced x-ray sources.

    View details for DOI 10.1088/0031-9155/55/18/008

    View details for Web of Science ID 000281481500008

    View details for PubMedID 20736494

  • Antiproton radiotherapy: peripheral dose from secondary neutrons Hyp. Interact. Fahimian BP, DeMarco J, Keyes R, Bassler N, Iwamoto K, Zankl M, Holzscheiter M 2009; 194 (1): 313-318
  • Enhancement of four-dimensional cone-beam computed tomography by compressed sensing with Bregman iteration JOURNAL OF X-RAY SCIENCE AND TECHNOLOGY Choi, K., Fahimian, B. P., Li, T., Suh, T., Lei, X. 2013; 21 (2): 177-192

    Abstract

    In four-dimensional (4D) cone-beam computed tomography (CBCT), there is a spatio-temporal tradeoff that currently limits the accuracy. The aim of this study is to develop a Bregman iteration based formalism for high quality 4D CBCT image reconstruction from a limited number of low-dose projections. The 4D CBCT problem is first divided into multiple 3D CBCT subproblems by grouping the projection images corresponding to the phases. To maximally utilize the information from the under-sampled projection data, a compressed sensing (CS) method with Bregman iterations is employed for solving each subproblem. We formulate an unconstrained optimization problem based on least-square criterion regularized by total-variation. The least-square criterion reflects the inconsistency between the measured and the estimated line integrals. Furthermore, the unconstrained problem is updated and solved repeatedly by Bregman iterations. The performance of the proposed algorithm is demonstrated through a series of simulation studies and phantom experiments, and the results are compared to those of previously implemented compressed sensing technique using other gradient-based methods as well as conventional filtered back-projection (FBP) results. The simulation and experimental studies have shown that artifact suppressed images can be obtained with as small as 41 projections per phase, which is adequate for clinical 4D CBCT reconstruction. With such small number of projections, the conventional FDK failed to yield meaningful 4D CBCT images, and CS technique using conjugate gradient was not able to recover sharp edges. The proposed method significantly reduces the radiation dose and scanning time to achieve the high quality images compared to the 4D CBCT imaging based on the conventional FDK technique and the existing CS techniques.

    View details for DOI 10.3233/XST-130371

    View details for Web of Science ID 000319344700003

    View details for PubMedID 23694910

  • A Bayesian approach to real-time 3D tumor localization via monoscopic x-ray imaging during treatment delivery MEDICAL PHYSICS Li, R., Fahimian, B. P., Xing, L. 2011; 38 (7): 4205-4214

    Abstract

    Monoscopic x-ray imaging with on-board kV devices is an attractive approach for real-time image guidance in modern radiation therapy such as VMAT or IMRT, but it falls short in providing reliable information along the direction of imaging x-ray. By effectively taking consideration of projection data at prior times and/or angles through a Bayesian formalism, the authors develop an algorithm for real-time and full 3D tumor localization with a single x-ray imager during treatment delivery.First, a prior probability density function is constructed using the 2D tumor locations on the projection images acquired during patient setup. Whenever an x-ray image is acquired during the treatment delivery, the corresponding 2D tumor location on the imager is used to update the likelihood function. The unresolved third dimension is obtained by maximizing the posterior probability distribution. The algorithm can also be used in a retrospective fashion when all the projection images during the treatment delivery are used for 3D localization purposes. The algorithm does not involve complex optimization of any model parameter and therefore can be used in a "plug-and-play" fashion. The authors validated the algorithm using (1) simulated 3D linear and elliptic motion and (2) 3D tumor motion trajectories of a lung and a pancreas patient reproduced by a physical phantom. Continuous kV images were acquired over a full gantry rotation with the Varian TrueBeam on-board imaging system. Three scenarios were considered: fluoroscopic setup, cone beam CT setup, and retrospective analysis.For the simulation study, the RMS 3D localization error is 1.2 and 2.4 mm for the linear and elliptic motions, respectively. For the phantom experiments, the 3D localization error is < 1 mm on average and < 1.5 mm at 95th percentile in the lung and pancreas cases for all three scenarios. The difference in 3D localization error for different scenarios is small and is not statistically significant.The proposed algorithm eliminates the need for any population based model parameters in monoscopic image guided radiotherapy and allows accurate and real-time 3D tumor localization on current standard LINACs with a single x-ray imager.

    View details for DOI 10.1118/1.3598435

    View details for Web of Science ID 000292521100037

    View details for PubMedID 21859022

  • Quantitative 3D imaging of whole, unstained cells by using X-ray diffraction microscopy PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA Jiang, H., Song, C., Chen, C., Xu, R., Raines, K. S., Fahimian, B. P., Lu, C., Lee, T., Nakashima, A., Urano, J., Ishikawa, T., Tamanoi, F., Miao, J. 2010; 107 (25): 11234-11239

    Abstract

    Microscopy has greatly advanced our understanding of biology. Although significant progress has recently been made in optical microscopy to break the diffraction-limit barrier, reliance of such techniques on fluorescent labeling technologies prohibits quantitative 3D imaging of the entire contents of cells. Cryoelectron microscopy can image pleomorphic structures at a resolution of 3-5 nm, but is only applicable to thin or sectioned specimens. Here, we report quantitative 3D imaging of a whole, unstained cell at a resolution of 50-60 nm by X-ray diffraction microscopy. We identified the 3D morphology and structure of cellular organelles including cell wall, vacuole, endoplasmic reticulum, mitochondria, granules, nucleus, and nucleolus inside a yeast spore cell. Furthermore, we observed a 3D structure protruding from the reconstructed yeast spore, suggesting the spore germination process. Using cryogenic technologies, a 3D resolution of 5-10 nm should be achievable by X-ray diffraction microscopy. This work hence paves a way for quantitative 3D imaging of a wide range of biological specimens at nanometer-scale resolutions that are too thick for electron microscopy.

    View details for DOI 10.1073/pnas.1000156107

    View details for Web of Science ID 000279058000017

    View details for PubMedID 20534442

  • Development and Optimization of Regularized Tomographic Reconstruction Algorithms Utilizing Equally-Sloped Tomography IEEE TRANSACTIONS ON IMAGE PROCESSING Mao, Y., Fahimian, B. P., Osher, S. J., Miao, J. 2010; 19 (5): 1259-1268

    Abstract

    We develop two new algorithms for tomographic reconstruction which incorporate the technique of equally-sloped tomography (EST) and allow for the optimized and flexible implementation of regularization schemes, such as total variation constraints, and the incorporation of arbitrary physical constraints. The founding structure of the developed algorithms is EST, a technique of tomographic acquisition and reconstruction first proposed by Miao in 2005 for performing tomographic image reconstructions from a limited number of noisy projections in an accurate manner by avoiding direct interpolations. EST has recently been successfully applied to coherent diffraction microscopy, electron microscopy, and computed tomography for image enhancement and radiation dose reduction. However, the bottleneck of EST lies in its slow speed due to its higher computation requirements. In this paper, we formulate the EST approach as a constrained problem and subsequently transform it into a series of linear problems, which can be accurately solved by the operator splitting method. Based on these mathematical formulations, we develop two iterative algorithms for tomographic image reconstructions through EST, which incorporate Bregman and continuative regularization. Our numerical experiment results indicate that the new tomographic image reconstruction algorithms not only significantly reduce the computational time, but also improve the image quality. We anticipate that EST coupled with the novel iterative algorithms will find broad applications in X-ray tomography, electron microscopy, coherent diffraction microscopy, and other tomography fields.

    View details for DOI 10.1109/TIP.2009.2039660

    View details for Web of Science ID 000276815900013

    View details for PubMedID 20051344

  • Three-dimensional structure determination from a single view NATURE Raines, K. S., Salha, S., Sandberg, R. L., Jiang, H., Rodriguez, J. A., Fahimian, B. P., Kapteyn, H. C., Du, J., Miao, J. 2010; 463 (7278): 214-217

    Abstract

    The ability to determine the structure of matter in three dimensions has profoundly advanced our understanding of nature. Traditionally, the most widely used schemes for three-dimensional (3D) structure determination of an object are implemented by acquiring multiple measurements over various sample orientations, as in the case of crystallography and tomography, or by scanning a series of thin sections through the sample, as in confocal microscopy. Here we present a 3D imaging modality, termed ankylography (derived from the Greek words ankylos meaning 'curved' and graphein meaning 'writing'), which under certain circumstances enables complete 3D structure determination from a single exposure using a monochromatic incident beam. We demonstrate that when the diffraction pattern of a finite object is sampled at a sufficiently fine scale on the Ewald sphere, the 3D structure of the object is in principle determined by the 2D spherical pattern. We confirm the theoretical analysis by performing 3D numerical reconstructions of a sodium silicate glass structure at 2 A resolution, and a single poliovirus at 2-3 nm resolution, from 2D spherical diffraction patterns alone. Using diffraction data from a soft X-ray laser, we also provide a preliminary demonstration that ankylography is experimentally feasible by obtaining a 3D image of a test object from a single 2D diffraction pattern. With further development, this approach of obtaining complete 3D structure information from a single view could find broad applications in the physical and life sciences.

    View details for DOI 10.1038/nature08705

    View details for Web of Science ID 000273582700032

    View details for PubMedID 20016484

  • Three-dimensional coherent x-ray diffractive imaging from a single view 2010 CONFERENCE ON LASERS AND ELECTRO-OPTICS (CLEO) AND QUANTUM ELECTRONICS AND LASER SCIENCE CONFERENCE (QELS) Sandberg, R. L., Raines, K. S., Salha, S., Jiang, H., Rodriguez, J. A., Fahimian, B. P., Kapteyn, H. C., Murnane, M. M., Du, J., Miao, J. 2010
  • Radiation dose reduction and image enhancement in biological imaging through equally-sloped tomography JOURNAL OF STRUCTURAL BIOLOGY Lee, E., Fahimian, B. P., Iancu, C. V., Suloway, C., Murphy, G. E., Wright, E. R., Castano-Diez, D., Jensen, G. J., Miao, J. 2008; 164 (2): 221-227

    Abstract

    Electron tomography is currently the highest resolution imaging modality available to study the 3D structures of pleomorphic macromolecular assemblies, viruses, organelles and cells. Unfortunately, the resolution is currently limited to 3-5nm by several factors including the dose tolerance of biological specimens and the inaccessibility of certain tilt angles. Here we report the first experimental demonstration of equally-sloped tomography (EST) to alleviate these problems. As a proof of principle, we applied EST to reconstructing frozen-hydrated keyhole limpet hemocyanin molecules from a tilt-series taken with constant slope increments. In comparison with weighted back-projection (WBP), the algebraic reconstruction technique (ART) and the simultaneous algebraic reconstruction technique (SART), EST reconstructions exhibited higher contrast, less peripheral noise, more easily detectable molecular boundaries and reduced missing wedge effects. More importantly, EST reconstructions including only two-thirds the original images appeared to have the same resolution as full WBP reconstructions, suggesting that EST can either reduce the dose required to reach a given resolution or allow higher resolutions to be achieved with a given dose. EST was also applied to reconstructing a frozen-hydrated bacterial cell from a tilt-series taken with constant angular increments. The results confirmed similar benefits when standard tilts are utilized.

    View details for DOI 10.1016/j.jsb.2008.07.011

    View details for Web of Science ID 000260588500006

    View details for PubMedID 18771735

Conference Proceedings


  • Binary Moving Blocker-based Scatter Correction for Single Scan Cone Beam CT System With Off-Centered Detector LEE, H., Fahimian, B. P., Xing, L. ELSEVIER SCIENCE INC. 2012: S797-S797
  • Single Scan Scatter Correction in Cone Beam CT Using a Stationary Boundary Blocker and Compressed Sensing-based Scatter Estimation Meng, B., LEE, H., Xing, L., Fahimian, B. P. ELSEVIER SCIENCE INC. 2012: S82-S83
  • Prone Partial Breast Coronal Arc Irradiation: Combining Intensity Modulated Delivery With Dynamic Motion of the Couch Fahimian, B. P., Yu, V., Xing, L., Horst, K., Hristov, D. ELSEVIER SCIENCE INC. 2012: S214-S214
  • Prospectively Gated CBCT for Volumetric Image Guidance in SBRT Fahimian, B. P., Xing, L. ELSEVIER SCIENCE INC. 2012: S199-S200
  • A Binary Moving Blocker-Based Scatter Correction Technique for Cone-Beam CT with Width-Truncated Projections LEE, H., Fahimian, B., Xing, L. AMER ASSOC PHYSICISTS MEDICINE AMER INST PHYSICS. 2012: 3892-3892
  • Improving Respiration-Gated IMRT Delivery Efficiency by Dual-Gating at Inhale and Exhale: Evaluation of Planning On Eclipse and the Need for Accurate Image Registration Geneser, S., Fahimian, B., Xing, L. AMER ASSOC PHYSICISTS MEDICINE AMER INST PHYSICS. 2012: 3671-3671
  • Single-Scan Scatter Correction in Cone Beam CT Using Stationary Boundary Blockers and Compressed Sensing Meng, B., Xing, L., Fahimian, B. AMER ASSOC PHYSICISTS MEDICINE AMER INST PHYSICS. 2012: 3891-3891
  • Dual Gated Volumetric Modulated Arc Therapy Wu, J., Fahimian, B., Wu, H., Xing, L. AMER ASSOC PHYSICISTS MEDICINE AMER INST PHYSICS. 2012: 3909-3909
  • Scatter-free CBCT Imaging using a Beam Blocker and an Incoherence-enhancing Compressed Sensing Method LEE, H., Fahimian, B. P., LEE, R., Xing, L. ELSEVIER SCIENCE INC. 2011: S59-S60
  • Accelerated Partial Breast Arc Irradiation using Synchronous Trajectories of the Couch and Gantry: Geometric and Dosimetric Evaluation Fahimian, B. P., Xing, L., Horst, K. C., Hristov, D. H. ELSEVIER SCIENCE INC. 2011: S199-S199
  • Energy Modulated Electronic Brachytherapy Fahimian, B. P., Chen, T., DeMarco, J. J., Xing, L. ELSEVIER SCIENCE INC. 2011: S201-S201
  • Image Guidance On the TrueBeam STx: Evaluation of CBCT Imaging Dose and Quality Maxim, P. G., Fahimian, B. P., Xing, L. ELSEVIER SCIENCE INC. 2011: S849-S850
  • Reducing Gated IMRT Delivery Times: Dual-gated Delivery Optimization and Implementation Geneser, S., Fahimian, B., Kielar, K., Xing, L. ELSEVIER SCIENCE INC. 2011: S202-S202

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