Type 1 diabetes and dyslipidemia are known risk factors for cardiovascular disease (CVD), but the relationship between lipid levels in youth with type 1 diabetes and future CVD remains unknown.To characterize lipid levels and CVD risk factors over time in youth with type 1 diabetes.The study included adolescents with type 1 diabetes (12-25 yr) with a minimum of 3-yr follow-up.A longitudinal prospective, observational study of 46 youth with type 1 diabetes was performed. Fasting lipid profiles, A1C, and body mass index (BMI) were measured every 6 months for at least 3 yr (median 4.2 yr). Low-density lipoprotein (LDL)-cholesterol, total cholesterol (TC), and triglycerides (TG) were divided into categorical variables.At baseline, median age was 14.3 yr, mean diabetes duration was 6.4 ± 3.8 yr, mean A1C was 8.1 ± 1.0%, and median BMI z-score was 0.92. Fifty percent of subjects had LDL levels ? 100 mg/dL (? 2.6 mmol/L) at study onset. After adjusting for confounding factors, increasing BMI z-score [? = 0.2, 95% confidence interval (CI ) = 0.03-0.38, p = 0.03] and increasing A1C (? = 0.18, 95% CI = 0.08-0.29, p = 0.001) were associated with increasing LDL category over time. Non-Hispanic ethnicity (? = 0.45, 95% CI = 0.12-0.79, p = 0.008) and family history of stroke (? = 0.38, 95% CI = 0.04-0.72, p = 0.03) were also associated with increasing LDL category. Age, diabetes duration, and tobacco exposure were not related to change in LDL. Increasing A1C was associated with increases in TG (? = 18.1, 95% CI = 2.3-33.9, p = 0.03), TC (? = 20.3, 95% CI = 9.0-31.5, p < 0.0001), and LDL (? = 13.4, 95% CI = 3.17- 23.6, p = 0.01).Glycemic control and BMI are modifiable risk factors for dyslipidemia in youth with type 1 diabetes.
View details for DOI 10.1111/j.1399-5448.2010.00733.x
View details for Web of Science ID 000290964000001
View details for PubMedID 21392191