Clinical Focus

  • Neurosurgery

Academic Appointments

Honors & Awards

  • Visiting Professor Guest Speaker, NIH Clinical Center, Bethesda, Washington, DC (10/2016)

Boards, Advisory Committees, Professional Organizations

  • Board Certified, European Association of Neurosurgical Societies (EANS) (2018 - Present)
  • Member, European Association of Neurosurgical Societies (EANS), Radiosurgery Section (2017 - Present)
  • Member, European Association of Neurosurgical Societies (EANS), Neuro-oncology Section (2017 - Present)

Professional Education

  • Fellowship:Brigham and Women's Hospital Anesthesiology Residency (2016) MA
  • PhD Training:University of Florence (2016) Italy
  • Fellowship:Cleveland Clinic Foundation (2017) OH
  • Residency:University of Pisa (2015) Italy
  • Internship:University of Pisa (2009) Italy
  • Medical Education:University of Pisa (2008) Italy
  • Clinical Fellow, Cleveland Clinic Foundation, Cleveland, OH, Neurosurgical Oncology (2017)
  • Clinical Fellow, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, Image-guided Neurosurgery (2016)
  • Ph.D., University of Florence, Italy (2016)
  • Residency, University of Pisa, Italy, Neurosurgery (2015)
  • Research Fellow, University of Pittsburgh (UPMC), Pittsburgh, PA, Neurosurgical Anatomy (2015)
  • M.D., University of Pisa, Italy (2008)


All Publications

  • Commentary: Peritumoral Edema/Tumor Volume Ratio: A Strong Survival Predictor for Posterior Fossa Metastases. Neurosurgery Chow, K. K., Meola, A., Chang, S. D. 2018

    View details for DOI 10.1093/neuros/nyy281

    View details for PubMedID 29982666

  • Letter: Navigation-Linked Heads-Up Display in Intracranial Surgery: Early Experience. Operative neurosurgery (Hagerstown, Md.) Meola, A., Chang, S. D. 2018; 14 (6): E71–E72

    View details for DOI 10.1093/ons/opy048

    View details for PubMedID 29590481

  • Gold Nanoparticles for Brain tumor imaging: a Systematic Review FRONTIERS IN NEUROLOGY Meola, A., Rao, J., Chaudhary, N., Sharma, M., Chang, S. D. 2018; 9: 328


    Demarcation of malignant brain tumor boundaries is critical to achieve complete resection and to improve patient survival. Contrast-enhanced brain magnetic resonance imaging (MRI) is the gold standard for diagnosis and pre-surgical planning, despite limitations of gadolinium (Gd)-based contrast agents to depict tumor margins. Recently, solid metal-based nanoparticles (NPs) have shown potential as diagnostic probes for brain tumors. Gold nanoparticles (GNPs) emerged among those, because of their unique physical and chemical properties and biocompatibility. The aim of the present study is to review the application of GNPs for in vitro and in vivo brain tumor diagnosis.We performed a PubMed search of reports exploring the application of GNPs in the diagnosis of brain tumors in biological models including cells, animals, primates, and humans. The search words were "gold" AND "NP" AND "brain tumor." Two reviewers performed eligibility assessment independently in an unblinded standardized manner. The following data were extracted from each paper: first author, year of publication, animal/cellular model, GNP geometry, GNP size, GNP coating [i.e., polyethylene glycol (PEG) and Gd], blood-brain barrier (BBB) crossing aids, imaging modalities, and therapeutic agents conjugated to the GNPs.The PubMed search provided 100 items. A total of 16 studies, published between the 2011 and 2017, were included in our review. No studies on humans were found. Thirteen studies were conducted in vivo on rodent models. The most common shape was a nanosphere (12 studies). The size of GNPs ranged between 20 and 120 nm. In eight studies, the GNPs were covered in PEG. The BBB penetration was increased by surface molecules (nine studies) or by means of external energy sources (in two studies). The most commonly used imaging modalities were MRI (four studies), surface-enhanced Raman scattering (three studies), and fluorescent microscopy (three studies). In two studies, the GNPs were conjugated with therapeutic agents.Experimental studies demonstrated that GNPs might be versatile, persistent, and safe contrast agents for multimodality imaging, thus enhancing the tumor edges pre-, intra-, and post-operatively improving microscopic precision. The diagnostic GNPs might also be used for multiple therapeutic approaches, namely as "theranostic" NPs.

    View details for DOI 10.3389/fneur.2018.00328

    View details for Web of Science ID 000431972100001

    View details for PubMedID 29867737

    View details for PubMedCentralID PMC5960696