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The laboratory is focused on human cancers that are dependent on EGFR cell signaling. In particular, we recently established that the AGR2 protein serves an essential role in EGFR presentation to the cell surface, and represents a novel mechanism of regulating cell signaling. We have long history in pancreatic biology and disease. Recent work elucidated the role of EGFR cell signaling during tissue regeneration in response to pancreatitis. Our overall hypothesis is that EGFR signaling serves a vital role in tissue regeneration, and that chronic injury and persistent wound healing lead to the development of preneoplastic lesions and eventually cancer. We hypothesize that this pathway is active in a large number of human cancers. If true, new opportunities for the treatment of preneoplastic and neoplastic diseases are provided, which represents a major focus of the laboratory. Active projects are focused on cancer pathogenesis, tissue regeneration, development of diagnostic assays, and drug development.
Novel Serum Markers for Monitoring Response to Anti-Cancer Therapy
The purpose of this study is to measure the levels of serum proteins and other biomarkers in
cancer patients and in patients suspected of having cancer. We believe that some of these
markers may be useful for confirming the diagnosis or for selecting patients for specific
types of cancer therapies. These markers may also help to predict response to therapy,
relapse after therapy, and survival after therapy.
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