Journal Articles

  • Chinese Box turtle (Cuora flavomarginata) with lymphoid leukemia characterized by immunohistochemical and cytochemical phenotyping. Veterinary Clinical Pathology Bezjian, M., Diep, A. N., de Matos, R., Schaefer, D. 2013
  • Transient hyperlipidemia in a litter of kittens JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE Blackstock, K. J., Schoeffler, G., Wakshlag, J. J., Diep, A. N., Bauer, J. E. 2012; 22 (6): 703-709


    To describe an entire litter of kittens with severe hyperlipidemia and subsequent successful, low-cost treatment that included high protein enteral support and parasite control. Previous case studies of similarly affected kittens have focused on a genetic etiology and on advanced interventions. The role of negative energy balance and additional factors influencing hyperlipidemia, as well as treatment and prognosis are discussed.Three of 6 kittens died or were euthanized due to severe clinical signs attributable to multiorgan failure associated with subacute hyperlipidemia. The remaining 3 kittens, although subclinical, were found to have similar biochemical abnormalities, including severe anemia and hypertriglyceridemia. Flea treatment and weaning with assisted enteral support prevented the worsening of clinical signs and returned biochemical parameters to within reference intervals.Transient hyperlipidemia in kittens has been previously reported and successfully treated with administration of oxygen, blood transfusion, and diet change; these treatment recommendations may not always be financially feasible, resulting in euthanasia of affected kittens. In contrast, this report describes a successful, low-cost, outpatient approach of flea control, weaning, and introduction of a high protein enteral diet. It also highlights the importance of screening and treating seemingly unaffected littermates, provides new, previously unreported biochemical and histopathology findings, and proposes that negative energy balance is a significant factor in the development of transient hyperlipidemia in kittens.

    View details for DOI 10.1111/j.1476-4431.2012.00797.x

    View details for Web of Science ID 000312159200011

    View details for PubMedID 23110600

  • Pathology in Practice JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION Diep, A. N., Fleis, R. I. 2012; 240 (4): 391-393
  • Pathology in practice. Widespread, metastatic liposarcoma and moderate, acute, diffuse centrilobular hepatic necrosis. Journal of the American Veterinary Medical Association Diep, A. N., Fleis, R. I. 2012; 240 (4): 391-393

    View details for DOI 10.2460/javma.240.4.391

    View details for PubMedID 22309010

  • Spinal cord nephroblastoma in dogs: 11 cases (1985-2007) JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION Brewer, D. M., Cerda-Gonzalez, S., Dewey, C. W., Diep, A. N., Van Horne, K., McDonough, S. P. 2011; 238 (5): 618-624


    To evaluate clinical features and outcome of dogs with a confirmed spinal cord nephroblastoma and to describe the use of Wilms tumor-1 (WT-1) immunohistochemical staining to confirm a diagnosis of nephroblastoma in dogs.Retrospective case series. Animals-11 dogs with a spinal cord nephroblastoma.Medical records of dogs with a spinal cord nephroblastoma were reviewed. Information extracted included signalment, history, clinical signs, results of diagnostic testing, tumor location, treatment, and outcome. The diagnosis was confirmed through histologic review and WT-1 immunohistochemical staining of a tumor sample. In dogs with negative results for staining with WT-1, staining for cytokeratin, vimentin, and glial fibrillar acidic protein was performed.11 dogs had a spinal cord tumor with a histologic appearance and immunohistochemical staining consistent with a nephroblastoma. Positive results for staining with WT-1 were detected in 9 of 11 dogs. Age at admission ranged from 5 to 48 months (median, 14 months). Nine dogs were female. All had progressive paraparesis, paraplegia, or ataxia. Duration of clinical signs ranged from 2 to 60 days (median, 14 days). Median survival time was 30 days from the time of diagnosis. Median survival time in dogs treated via surgical resection was 70.5 days.The prognosis for dogs with a spinal cord nephroblastoma appeared to be poor, although combined surgical resection and radiation therapy may provide a good functional outcome. Results for staining with WT-1 can be used to support a diagnosis of nephroblastoma.

    View details for Web of Science ID 000287680600017

    View details for PubMedID 21355804

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