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Neutrophils are the most abundant circulating leukocytes in humans, comprising the first line of innate immune defense. As neutrophils migrate towards sites of infection and inflammation they encounter a highly heterogeneous environment. Tasked to navigate through microscale obstacles, neutrophils often develop multiple competing fronts, raising the question of how the cell is able to select which front to maintain and which front(s) to abandon. To answer this question, I challenge chemotaxing HL-60 neutrophil-like cells with microfluidic devices containing obstacles and combine quantitative microscopy with sub-cellular optogenetics, statistical learning, and data science.