Bio

Clinical Focus


  • Medical Oncology

Academic Appointments


Professional Education


  • Board Certification: Medical Oncology, American Board of Internal Medicine (2014)
  • Fellowship:Stanford University Hospital - Oncology/ Fellow (2005) CA
  • Fellowship:Stanford University - Bone Marrow Transplantation (2003) CA
  • Residency:Hospital of the University of Pennsylvania Dept of Internal Medicine (2002) PA
  • Internship:Hospital of the University of Pennsylvania Dept of Internal Medicine (2001) PA
  • Medical Education:Vanderbilt School of Medicine (2000) TN

Publications

All Publications


  • The actin-binding protein profilin is required for germline stem cell maintenance and germ cell enclosure by somatic cyst cells DEVELOPMENT Shields, A. R., Spence, A. C., Yamashita, Y. M., Davies, E. L., Fuller, M. T. 2014; 141 (1): 73-82

    Abstract

    Specialized microenvironments, or niches, provide signaling cues that regulate stem cell behavior. In the Drosophila testis, the JAK-STAT signaling pathway regulates germline stem cell (GSC) attachment to the apical hub and somatic cyst stem cell (CySC) identity. Here, we demonstrate that chickadee, the Drosophila gene that encodes profilin, is required cell autonomously to maintain GSCs, possibly facilitating localization or maintenance of E-cadherin to the GSC-hub cell interface. Germline specific overexpression of Adenomatous Polyposis Coli 2 (APC2) rescued GSC loss in chic hypomorphs, suggesting an additive role of APC2 and F-actin in maintaining the adherens junctions that anchor GSCs to the niche. In addition, loss of chic function in the soma resulted in failure of somatic cyst cells to maintain germ cell enclosure and overproliferation of transit-amplifying spermatogonia.

    View details for DOI 10.1242/dev.101931

    View details for Web of Science ID 000328944500009

    View details for PubMedID 24346697