Current Research and Scholarly Interests
Historically, children have represented an understudied, ‘orphan’ population in the field of clinical pharmacology. Many medicines used in children have not been rigorously tested and lack the same level of evidence to help guide dosing as compared to adults. Yet, an in-depth understanding of a drug's clinical pharmacology is essential for its safe and effective use in children.
My research interests focus on understanding the clinical pharmacokinetics (PK) and pharmacodynamics (PD) of medicines used in complex pediatric populations. This includes identifying sources of variation in drug response through the application of population PK-PD approaches and modeling and simulation. The goal is to ultimately apply this quantitative understanding to guide therapeutic decision-making in infants and children.
Learn about the Importance of Children in Clinical Studies - http://www.nhlbi.nih.gov/childrenandclinicalstudies/index.php