Melanie Hayden Gephart

Professor of Neurosurgery and, by courtesy, of Neurology

Bio

I am a brain tumor neurosurgeon, treating patients with primary and metastatic brain tumors. I treat patients with malignant and benign tumors, including glioma, brain metastases, meningioma, and vestibular schwannomas. I direct the Stanford Brain Tumor Center and the Stanford Brain Metastasis Consortium, collaborative unions of physicians and scientists looking to improve our understanding and treatment of brain tumors. My laboratory seeks greater understanding of the mechanisms driving tumorigenesis and disease progression in malignant brain tumors. We study how rare cancer cell populations survive and migrate in the brain, inadvertently supported by native brain cells. We develop novel cell free nucleic acid biomarkers to track brain cancer treatment response, relapse, and neurotoxicity. Our bedside-to-bench-to-bedside research model builds on a foundation of generously donated patient samples, where we test mechanisms of brain cancer growth, develop novel pre-clinical models that reliably recapitulate the human disease, and facilitate clinical trials of new treatments for patients with brain cancer.

www.GephartLab.com
www.GBMseq.org
https://stan.md/BrainMets
@HaydenGephartMD

Clinical Focus

Neurosurgery

Academic Appointments

Professor - University Medical Line, Neurosurgery
Professor - University Medical Line (By courtesy), Neurology & Neurological Sciences
Member, Bio-X
Member, Maternal & Child Health Research Institute (MCHRI)
Member, Stanford Cancer Institute

Administrative Appointments

Associate Program Director, Neurosurgery Residency (2022 - Present)
Co-Director, Stanford Brain Tumor Center, Stanford University (2018 - Present)
Director, Stanford Brain Metastases Consortium (2018 - Present)

Professional Education

Neurosurgery Residency, Stanford University (2014)
MD, University of California at San Diego (2007)
Board Certification: American Board of Neurological Surgery, Neurosurgery (2018)
Masters of Advanced Sciences, University of California at San Diego, Clinical Research (2007)
BS, University of California at San Diego, Neuroscience and Physiology (2001)

Contact

Academic mghayden@stanford.edu

Stanford Brain Tumor Center Tel: 650 497 7777

Clinical Stanford Neuroscience Health Center 213 Quarry Rd 4th Fl MC 5958 Palo Alto CA 94304 Tel: (650) 723-6469 Fax: (650) 725-0390
Clinical Stanford Cancer Center 875 Blake Wilbur Dr Clinic A MC 6560 Stanford CA 94305 Tel: (650) 498-6000 Fax: (650) 724-3556
Clinical Neurosciences and Pediatric Surgery 730 Welch Rd 2nd Fl MC 5883 Palo Alto CA 94304 Tel: (650) 723-0991 Fax: (650) 725-5086

2022-23 Courses

Independent Studies
- Directed Reading in Neurosurgery
  NSUR 299 (Aut, Win, Spr)
- Early Clinical Experience in Neurosurgery
  NSUR 280 (Aut, Win, Spr)
- Graduate Research
  NSUR 399 (Aut, Win, Spr)
- Medical Scholars Research
  NSUR 370 (Aut, Win, Spr, Sum)
- Undergraduate Research
  NSUR 199 (Aut, Win, Spr)

Stanford Advisees

Med Scholar Project Advisor
Guan Li, Adrian Rodrigues
Postdoctoral Faculty Sponsor
Giuseppe Barisano, Shruti Jain, Zheng Hao Samuel Wong

All Publications

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The development and implementation of computerized, image-guided surgical tools to be used during minimally invasive brain operations. The clinical outcome of new technologies, and in particular the application of radiosurgery, for the treatment of brain tumors. The creation of new radiosurgical techniques for a wide array of brain and spine disorders.

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Steven D. Chang, MD

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Cancer > Neuro Oncology, Brain / Central Nervous System Tumors, Brain / Central Nervous System Tumors - Neuro Oncology, Brain / Central Nervous System Tumors - Neurosurgery, Neurological Surgery, Neurosurgery, Skull Base Tumors , Skull Base Tumors - Head and Neck Surgery, Spinal Cancer, Spinal Cancer - Neurosurgery, Spinal Cancer - Surgery, Acoustic Neuroma, Glioma, Astrocytic, Glioma, Glioblastoma, Glioblastoma with Sarcomatous Component, Astrocytoma, Ependymoma, Medulloblastoma, Meningioma, Intracranial Aneurysm, Carotid Stenosis, Arteriovenous Malformations, Intracranial Arteriovenous Malformations, ACTH-Secreting Pituitary Adenoma, Adenoma, Prolactin-Secreting, Pituitary, Diabetes Insipidus, Pituitary, Growth Hormone-Secreting Pituitary Adenoma, Hypothalamic-Pituitary Neoplasms, Neoplasms, Hypothalamic-Pituitary, PRL-Secreting Pituitary Adenoma, Pituitary ACTH Hypersecretion, Pituitary ACTH-Producing Cells, Pituitary ACTH-Secreting Cells, Pituitary Adenoma, Prolactin-Secreting, Pituitary Adrenocorticotropin-Secreting Cells, Pituitary Apoplexy, Pituitary Diseases, Pituitary FSH Hypersecretion, Pituitary Gland, Pituitary Growth Hormone-Secreting Cells, Pituitary Irradiation, Pituitary Neoplasms, Prolactin-Producing Pituitary Adenoma, Prolactin-Secreting Pituitary Adenoma, Vestibular Schwannoma, brain metastasis, Cyberknife, Radiosurgery, Stereotactic, Stereotactic Techniques, spinal avm, spinal tumor, Spinal Meningioma, spinal schwannoma, Trigeminal Neuralgia, Hemifacial Spasm, Glossopharyngeal Nerve Diseases, AVM (Arteriovenous Malformation) Intracranial, Stroke, Brain Tumor, Primary, Brain Tumor, Recurrent, Brain Tumors, Malignant Primary Brain Tumors, Primary Malignant Brain Tumors, Aneurysm, Cerebral, Acoustic Neuroma, Cerebellopontine Angle, Aneurysm, Anterior Cerebral Artery, Aneurysm, Middle Cerebral Artery, Aneurysm, Posterior Cerebral Artery, Anterior Cerebral Artery Aneurysm, Cerebral Cavernous Hemangioma, Cerebral Hemorrhage, Cerebral Vasculitis, Middle Cerebral Artery Aneurysm, Posterior Cerebral Artery Aneurysm, Vascular Malformations, Brain, Brain Aneurysm, Brain Neoplasms, Brain Revascularization, Neurogenetics, Neuroprotenomics, Neurocutaneous Syndromes, Glomus Tumor, Craniopharyngioma, Pituitary tumor
Research Interests
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Iris C. Gibbs, MD, FACR, FASTRO

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Medical history - especially the history of otology, neurosurgery, deafness, and quackery.

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