Current Research and Scholarly Interests
I am a physician-scientist who has established a human translational research group that fosters the development of young researchers to excel as both laboratory immunologists, and clinical translational researchers. Allogeneic hematopoietic stem cell transplantation (HSCT) can cure hematologic malignancies. In an effort to discover beneficial graft-v-tumor minor histocompatibility antigens and distinguish from detrimental graft-v-host disease(GVHD) mHA, the Miklos lab has pioneered protein microarray technologies screening for allogeneic antibodies, especially H-Y antigens following sex mismatched transplantation. Our observation that allogeneic HY antibodies develop in association with chronic GVHD has supported a series of clinical trials testing rituximab cGVHD therapy. More recently, we have applied high throughput sequencing B and T cell VDJ receptor sequences enabling: 1) lymphoid disease quantification, 2) detailed B and T cell donor reconstitution kinetics, and 3) clonal analysis of antigen specific responses following allo-HCT.