Charles C. Lin, MD

All Publications

• Successful DMEK After Intraoperative Graft Inversion CORNEA Yu, C. Q., Ta, C. N., Terry, M. A., Lin, C. C. 2015; 34 (1): 97-98

  Abstract

  Hardiness of a Descemet membrane endothelial keratoplasty (DMEK) graft is not well established. The aim of this study was to report a case of graft survival after intraoperative inversion.We describe a case of a 76-year-old man with Fuchs corneal dystrophy who underwent DMEK in the left eye. After deployment of the graft and a 15-minute sulfur hexafluoride gas fill, the graft was noted to be inverted. The graft was then reoriented and properly positioned.Because of progressive graft detachment, rebubble was required at 2 weeks after surgery. At 2 months after surgery, the graft was clear and fully adherent. Specular microscopy revealed 27.9% endothelial cell loss of the donor cornea.Despite intraoperative inversion, this DMEK graft remained viable without excessive endothelial cell loss.

  View details for PubMedID 25411936

• Scleral intraocular pressure measurement in cadaver eyes pre- and postkeratoprosthesis implantation. Investigative ophthalmology & visual science Lin, C. C., Chen, A., Jeng, B. H., Porco, T. C., Ou, Y., Han, Y. 2014; 55 (4): 2244-2250

  Abstract

  Purpose: To correlate scleral intraocular pressure (IOP) to assigned IOP using pneumatonometry in cadaver eyes before and after Boston type I keratoprosthesis (KPro) implantation. Methods: Corneal IOP and scleral IOP at the superonasal, superotemporal, inferotemporal, and inferonasal quadrants were measured using pneumatonometry in six cadaver eyes cannulated with an infusion line with assigned IOP held at 20, 30, 40, and 50 mmHg. Measurements of scleral IOP at the same location were repeated after a KPro was implanted. Correlations between scleral IOP and assigned IOP were analyzed for the entire group of eyes and for each individual eye before and after KPro. One eye was tested by another masked grader for inter-observer variability. Results: Scleral IOP measured higher than corneal IOP by a mean of 13.2 mmHg. For group analysis, pre-KPro scleral IOP had a positive and linear correlation with assigned IOP in all quadrants (P<0.00001), and this correlation was preserved after KPro implantation (P<0.00001). There was strong inter-observer agreement in all measurement sites (P< 0.001). In analyses of individual eyes, scleral IOP measured at the inferotemporal quadrant confirmed the strong linear association between scleral IOP and assigned IOP before and after KPro for all study eyes. A Bland-Altman plot showed that the difference in scleral IOP between pre-KPro and post-KPro eyes fell mostly within ±5mmHg. Conclusions: Scleral IOP measured by pneumatonometry may be used to estimate IOP in cadaver eyes with and without keratoprosthesis. This may be a potential modality for assessing IOP for patients with corneal pathology or keratoprosthesis.

  View details for DOI 10.1167/iovs.13-13153

  View details for PubMedID 24557348

• Rapid corneal adrenochrome deposition from topical ibopamine in the setting of infectious keratitis EYE Bhosai, S. J., Lin, C. C., Greene, J., BLOOMER, M. M., Jeng, B. H. 2013; 27 (1): 105-106

  View details for DOI 10.1038/eye.2012.217

  View details for Web of Science ID 000313557200018

  View details for PubMedID 23079754

• Seasonal Trends of Microbial Keratitis in South India CORNEA Lin, C. C., Lalitha, P., Srinivasan, M., Prajna, N. V., McLeod, S. D., Acharya, N. R., Lietman, T. M., Porco, T. C. 2012; 31 (10): 1123-1127

  Abstract

  Previous studies suggest that fungal keratitis is more common in hot humid climates and that bacterial keratitis is independent of seasonal variation. This study analyzes seasonal trends in the incidence of fungal and bacterial keratitis at the Aravind Eye Hospital in southeast India.Using microbiology records from August 2006 to July 2009, retrospective analyses of infectious keratitis were performed. Bacterial and fungal keratitis incidence data were analyzed for seasonal patterns.Among the 6967 infectious keratitis cases, cultures were performed in 5221 (74.9%) cases; among them, 3028 (58%) were positive. Of the culture-positive cases, 1908 (63%) and 1081 (35.7%) were of fungal and bacterial etiology, respectively. The predominant fungal organism was Fusarium spp (42.3%) and the predominant bacterial organisms were Streptococcus pneumoniae (35.1%), Pseudomonas aeruginosa (24.3%), and Nocardia spp (8.1%). Analyses revealed an uneven distribution of fungal keratitis throughout the year (P < 0.001) with peaks in July and January. No significant seasonal trend was observed for the combined bacterial keratitis group.A higher incidence of fungal keratitis occurs during the months corresponding to the windy and harvest seasons, during which time infection from vegetative corneal injury may be more likely. Robust screening efforts during these periods may mitigate visually debilitating sequelae from infectious keratitis.

  View details for DOI 10.1097/ICO.0b013e31825694d3

  View details for Web of Science ID 000308695200007

  View details for PubMedID 22868629

• Acanthamoeba Keratitis in South India: A Longitudinal Analysis of Epidemics OPHTHALMIC EPIDEMIOLOGY Lalitha, P., Lin, C. C., Srinivasan, M., Mascarenhas, J., Prajna, N. V., Keenan, J. D., McLeod, S. D., Acharya, N. R., Lietman, T. M., Porco, T. C. 2012; 19 (2): 111-115

  Abstract

  In light of the increased incidence of contact lens associated Acanthamoeba keratitis in recent years, this study analyzed longitudinal trends of its incidence among predominantly non-contact lens wearers in a high-volume referral center in South India.A retrospective analysis of microbiology laboratory records at the Aravind Eye Hospital from 1988-2009 was performed. The Maximum Excess Events Test (MEET) was used to identify epidemics of Acanthamoeba keratitis.There were a total of 38,529 unique cases of infectious keratitis evaluated over this time period, of which 372 were culture-positive for Acanthamoeba. Only three cases (0.9%) of Acanthamoeba keratitis occurred among contact lens wearers. MEET identified unique Acanthamoeba keratitis epidemics in 1993 and 2002.Discrete epidemics of Acanthamoeba keratitis occurred among a rural, non-contact lens wearing, population in South India in 1993 and 2002.

  View details for DOI 10.3109/09286586.2011.645990

  View details for Web of Science ID 000302067400010

  View details for PubMedID 22364672

• Trachoma control - Is azithromycin the answer for trichiasis too? ARCHIVES OF OPHTHALMOLOGY Lin, C., Lietman, T. 2007; 125 (6): 819-820

  View details for Web of Science ID 000247143600013

  View details for PubMedID 17562994

• Syphilis in China: results of a national surveillance programme LANCET Chen, Z., Zhang, G., Gong, X., Lin, C., Gao, X., Liang, G., Yue, X., Chen, X., Cohen, M. S. 2007; 369 (9556): 132-138

  Abstract

  After a massive syphilis epidemic in the first half of the 20th century, China was able to eliminate this infection for 20 years (1960-80). However, substantial changes in Chinese society have been followed by a resurgent epidemic of sexually transmitted diseases. Sporadic reports have provided clues to the magnitude of the spread of syphilis, but a national surveillance effort is needed to provide data for planning and intervention.We collected and assessed case report data from China's national sexually transmitted disease surveillance system and sentinel site network.In 1993, the reported total rate of cases of syphilis in China was 0.2 cases per 100,000, whereas primary and secondary syphilis alone represented 5.7 cases per 100,000 persons in 2005. The rate of congenital syphilis increased greatly with an average yearly rise of 71.9%, from 0.01 cases per 100,000 livebirths in 1991 to 19.68 cases per 100 000 livebirths in 2005.The results suggest that a range of unique biological and social forces are driving the spread of syphilis in China. A national campaign for detection and treatment of syphilis, and a credible prevention strategy, are urgently needed.

  View details for Web of Science ID 000243538200032

  View details for PubMedID 17223476

• Determinants of bone and blood lead levels among minorities living in the Boston area ENVIRONMENTAL HEALTH PERSPECTIVES Lin, C., Kim, R., Tsaih, S. W., Sparrow, D., Hu, H. 2004; 112 (11): 1147-1151

  Abstract

  We measured blood and bone lead levels among minority individuals who live in some of Boston's neighborhoods with high minority representation. Compared with samples of predominantly white subjects we had studied before, the 84 volunteers in this study (33:67 male:female ratio; 31-72 years of age) had similar educational, occupational, and smoking profiles and mean blood, tibia, and patella lead levels (3 microg/dL, 11.9 microg/g, and 14.2 microg/g, respectively) that were also similar. The slopes of the univariate regressions of blood, tibia, and patella lead versus age were 0.10 microg/dL/year (p < 0.001), 0.45 microg/g/year (p < 0.001), and 0.73 microg/g/year (p < 0.001), respectively. Analyses of smoothing curves and regression lines for tibia and patella lead suggested an inflection point at 55 years of age, with slopes for subjects greater than or equal to 55 years of age that were not only steeper than those of younger subjects but also substantially steeper than those observed for individuals > 55 years of age in studies of predominantly white participants. This apparent racial disparity at older ages may be related to differences in historic occupational and/or environmental exposures, or possibly the lower rates of bone turnover that are known to occur in postmenopausal black women. The higher levels of lead accumulation seen in this age group are of concern because such levels have been shown in other studies to predict elevated risks of chronic disease such as hypertension and cognitive dysfunction. Additional research on bone lead levels in minorities and their socioeconomic and racial determinants is needed.

  View details for DOI 10.1289/ehp.6705

  View details for Web of Science ID 000223743700032

  View details for PubMedID 15289158

• Rapid photochemical generation of ubiquinol through a radical pathway: An avenue for probing submillisecond enzyme kinetics JOURNAL OF ORGANIC CHEMISTRY Schultz, B. E., Hansen, K. C., Lin, C. C., Chan, S. I. 2000; 65 (10): 3244-3247

  View details for Web of Science ID 000087262500059

  View details for PubMedID 10814227