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Jeffrey Dunn, MD serves as the Lily Sarafan Director of Neuroimmunology, Clinical Professor and Chief of Neuroimmunology within the Department of Neurology & Neurological Sciences at Stanford University. He specializes in the diagnosis, treatment and research of immune-mediated diseases of the central nervous system, including Multiple Sclerosis, transverse myelitis, and Neuromyelitis Optica. Dr. Dunn is regarded nationally as among the foundational leaders in his field and is an elected Fellow of the American Academy of Neurology. He is the past Chair of the MS Section of the AAN. As Principal Investigator in more than 30 clinical research trials, Dr. Dunn has helped usher in new and improved immunotherapies for Multiple Sclerosis. He is the architect of Project BIG (see www.projectbig.com), an interdisciplinary research collaborative with Stanford scientists to identify biomarkers and candidate therapeutic targets within the paradigm of precision medicine. These collaborations have yielded such pivotal discoveries as EBV viral molecular mimicry as a driver of MS pathogenesis, a discovery recognized by the American Association for the Advancement of Science as a runner-up Science Breakthrough of the Year in 2022; and a T lymphocyte subtype having a key role in modulating human autoimmunity. Dr. Dunn is a US patent holder for a marker of MS treatment response with co-inventors, and has authored or co-authored more than 50 peer-reviewed manuscripts and abstracts. Dr. Dunn has been recognized for excellence in clinical teaching, as a 12 time winner of the Neurology Clerkship student teaching award, the Lysia Forno Award recipient for excellence in Neurology resident teaching, and by Arthur Bloomfield Awards and the Henry J. Kaiser Family Foundation. In recognition of his dedication to the educational mission, his name is given to the eponymous Fishers-Dunn Prize, awarded annually to best medical student teaching among active Neurology residents. His formative contributions to medical education were recognized by the inaugural Oscar Salvatierra Award for exceptional service to Stanford medical students awarded by the Stanford University School of Medicine.
An interdisciplinary research collaborative to investigate the brain, immune system and gut mechanisms pertaining to the cause and treatment of Multiple Sclerosis and related neuroimmune disorders.
Internation Journal of MS Care
Consortium of MS Centers
Translational research in the human application of emerging immunotherapies for neurological disease, focusing on Multiple Sclerosis, CIS, transverse myelitis and Neuromyelitis Optica (NMO). Collaborative research with Stanford and extramural scientific faculty to identify biomarkers of disease activity and treatment response in humans. Clinical trials to assess efficacy of emerging treatments for MS, CIS and NMO.
Best Available Therapy Versus Autologous Hematopoetic Stem Cell Transplant for Multiple Sclerosis (BEAT-MS)
This is a multi-center prospective rater-masked (blinded) randomized controlled trial of 156
participants, comparing the treatment strategy of Autologous Hematopoietic Stem Cell
Transplantation (AHSCT) to the treatment strategy of Best Available Therapy (BAT) for
treatment-resistant relapsing multiple sclerosis (MS). Participants will be randomized at a 1
to 1 (1:1) ratio.
All participants will be followed for 72 months after randomization (Day 0, Visit 0).
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A Rollover Study to Evaluate the Long-Term Safety and Efficacy of Ocrelizumab In Patients With Multiple Sclerosis
This is a Phase IIIb, single-arm, multicenter, OLE study. Participants receiving ocrelizumab
as an investigational medicinal product (IMP) in a Roche sponsored Parent study who continue
to receive ocrelizumab or are in safety follow-up at the time of the closure of their
respective Parent study (WA21092, WA21093 or WA25046) are eligible for enrollment in this
extension study. Participants who will continue ocrelizumab treatment will receive IMP based
on the dosage and administration received at the time of rollover from the Parent study.