Sonia Partap

Clinical Professor, Pediatric Neurology Clinical Professor (By courtesy), Neurosurgery Clinical Professor, Pediatrics

Clinical Focus

Pediatric Neuro-Oncology
Neurology with Special Qualifications in Child Neurology

Academic Appointments

Clinical Professor, Pediatric Neurology
Clinical Professor (By courtesy), Neurosurgery
Clinical Professor, Pediatrics
Member, Maternal & Child Health Research Institute (MCHRI)
Member, Wu Tsai Neurosciences Institute

Administrative Appointments

Pediatric Neuro-Oncology Fellowship Director, Stanford (2012 - Present)
Program Director, Neuro-Oncology Fellowship (UCNS), Stanford (2020 - Present)

Boards, Advisory Committees, Professional Organizations

Board Member, United Council for Neurologic Subspecialties (2025 - Present)
Pediatric Representative, American Academy of Neurology, Section of Neuro-Oncology (2015 - Present)
Councilor of the West, Child Neurology Society (2020 - 2022)
Member, Executive Committee, Section of Neurology, American Academy of Pediatrics (2012 - 2018)
Treasurer (elect), Brain Tumor Epidemiology Consortium (2012 - 2014)

Professional Education

Board Certification: United Council for Neurologic Subspecialties, Neuro-Oncology (2011)
Board Certification: American Board of Psychiatry and Neurology, Neurology with Special Qualifications in Child Neurology (2007)
Board Certification: American Board of Pediatrics, Pediatrics (2007)
Fellowship:, Stanford Children's & Stanford University Hospital, Neuro-Oncology (2007)
Residency: Childrens Hospital and Regional Medical Center Fellowships (2006) WA
Residency: Brown University Hospitals (2002) RI
Masters:, Stanford University, Epidemiology (2009)
Medical Education: University of Missouri Kansas City School of Medicine Registrar (2000) MO

Contact

Administrative Contact Julie Ng Administrative Assistant julieng@stanford.edu Tel: 650-736-0885

Clinical (Primary)

This is the primary clinic for this clinical provider. For additional clinical locations and information, please visit the link(s) listed below in the 'Additional Clinical Info' section.

Pediatric Oncology Clinic 725 Welch Rd Ste 160 Palo Alto CA 94304 Tel: (650) 497-8953 Fax: (650) 497-8101

Additional Clinical Info

Stanford Medicine Children's Health

Current Research and Scholarly Interests

My research interests involve the epidemiology, treatment and diagnosis of pediatric and young adult brain tumors. I am also interested in long-term neurologic effects and designing clinical trials to treat brain and spinal cord tumors.

Clinical Trials

Pembrolizumab in Treating Younger Patients With Recurrent, Progressive, or Refractory High-Grade Gliomas, Diffuse Intrinsic Pontine Gliomas, Hypermutated Brain Tumors, Ependymoma or Medulloblastoma Not Recruiting
More
This phase I trial studies the side effects and best dose of pembrolizumab and to see how well it works in treating younger patients with high-grade gliomas (brain tumors that are generally expected to be fast growing and aggressive), diffuse intrinsic pontine gliomas (brain stem tumors), brain tumors with a high number of genetic mutations, ependymoma or medulloblastoma that have come back (recurrent), progressed, or have not responded to previous treatment (refractory). Immunotherapy with monoclonal antibodies, such as pembrolizumab, may induce changes in the body's immune system, and may interfere with the ability of tumor cells to grow and spread.

Stanford is currently not accepting patients for this trial. For more information, please contact Cancer Clinical Trials Office (CCTO), 650-498-7061.
Lead Sponsor
Stanford Investigators
View full details
Testing the Safety and Tolerability of CX-4945 in Patients With Recurrent Medulloblastoma Who May or May Not Have Surgery Recruiting
More
This is a multi center, Phase I, Phase II and surgical study of the CX-4945 drug (silmitasertib sodium) for patients with recurrent SHH (Sonic Hedgehog) medulloblastoma
Lead Sponsor
Stanford Investigators
View full details
A Study Evaluating the Safety, Pharmacokinetics, and Efficacy of Alectinib in Pediatric Participants With ALK Fusion-Positive Solid or CNS Tumors Recruiting
More
This study will evaluate the safety, pharmacokinetics, and efficacy of alectinib in children and adolescents with ALK fusion-positive solid or CNS tumors for whom prior treatment has proven to be ineffective or for whom there is no satisfactory standard treatment available.
Lead Sponsor
Stanford Investigators
- Sonia Partap
View full details
A Study Comparing Abemaciclib Plus Temozolomide to Temozolomide Monotherapy in Children and Young Adults With High-grade Glioma Following Radiotherapy Recruiting
More
The purpose of this study is to measure the benefit of adding abemaciclib to the chemotherapy, temozolomide, for newly diagnosed high-grade glioma following radiotherapy. Your participation could last approximately 11 months and possibly longer depending upon how you and your tumor respond.
Lead Sponsor
Stanford Investigators
- Sonia Partap
View full details
131I-Omburtamab, in Recurrent Medulloblastoma and Ependymoma Not Recruiting
More
A Phase 2 study investigating the addition of cRIT 131I-omburtamab to irinotecan, temozolomide, and bevacizumab for patients with recurrent medulloblastoma. A feasibility cohort is included to assess the feasibility of incorporating cRIT 131I-omburtamab for patients with recurrent ependymoma. Direct intraventricular delivery of radiolabeled tumor-specific antibodies may aid in both the detection and treatment of recurrent disease for these highly specific pediatric patients with recurrent tumors.

Stanford is currently not accepting patients for this trial. For more information, please contact Cancer Clinical Trials Office (CCTO), 650-498-7061.
Lead Sponsor
Stanford Investigators
- Sonia Partap
View full details
DNA Analysis of Tumor Tissue Samples From Patients With Diffuse Brain Stem Glioma Not Recruiting
More
This multi-institutional study will prospectively collect tumor and constitutional tissue samples from patients with diffuse brainstem glioma and other types of brainstem gliomas either during therapy or at autopsy to perform an extensive analysis of genetic and molecular abnormalities in these tumors.

Stanford is currently not accepting patients for this trial. For more information, please contact Michelle Monje, .
Lead Sponsor
Stanford Investigators
- Paul Graham Fisher, MD
- Sonia Partap
View full details
A Clinical and Molecular Risk-Directed Therapy for Newly Diagnosed Medulloblastoma Not Recruiting
More
Historically, medulloblastoma treatment has been determined by the amount of leftover disease present after surgery, also known as clinical risk (standard vs. high risk). Recent studies have shown that medulloblastoma is made up of distinct molecular subgroups which respond differently to treatment. This suggests that clinical risk alone is not adequate to identify actual risk of recurrence. In order to address this, we will stratify medulloblastoma treatment in this phase II clinical trial based on both clinical risk (low, standard, intermediate, or high risk) and molecular subtype (WNT, SHH, or Non-WNT Non-SHH). This stratified clinical and molecular treatment approach will be used to evaluate the following: * To find out if participants with low-risk WNT tumors can be treated with a lower dose of radiation to the brain and spine, and a lower dose of the chemotherapy drug cyclophosphamide while still achieving the same survival rate as past St. Jude studies with fewer side effects. * To find out if adding targeted chemotherapy after standard chemotherapy will benefit participants with SHH positive tumors. * To find out if adding new chemotherapy agents to the standard chemotherapy will improve the outcome for intermediate and high risk Non-WNT Non-SHH tumors. * To define the cure rate for standard risk Non-WNT Non-SHH tumors treated with reduced dose cyclophosphamide and compare this to participants from the past St. Jude study. All participants on this study will have surgery to remove as much of the primary tumor as safely possible, radiation therapy, and chemotherapy. The amount of radiation therapy and type of chemotherapy received will be determined by the participant's treatment stratum. Treatment stratum assignment will be based on the tumor's molecular subgroup assignment and clinical risk. The participant will be assigned to one of three medulloblastoma subgroups determined by analysis of the tumor tissue for tumor biomarkers: * WNT (Strata W): positive for WNT biomarkers * SHH (Strata S): positive for SHH biomarkers * Non-WNT Non-SHH, Failed, or Indeterminate (Strata N): negative for WNT and SHH biomarkers or results are indeterminable Participants will then be assigned to a clinical risk group (low, standard, intermediate, or high) based on assessment of: * How much tumor is left after surgery * If the cancer has spread to other sites outside the brain \[i.e., to the spinal cord or within the fluid surrounding the spinal cord, called cerebrospinal fluid (CSF)\] * The appearance of the tumor cells under the microscope * Whether or not there are chromosomal abnormalities in the tumor, and if present, what type (also called cytogenetics analysis)

Stanford is currently not accepting patients for this trial. For more information, please contact Peds Hem/Onc CRAs, 650-723-5535.
Lead Sponsor
Stanford Investigators
View full details
Volitinib in Treating Patients With Recurrent or Refractory Primary CNS Tumors Not Recruiting
More
This phase I trial studies the side effects and best dose of volitinib in treating patients with primary central nervous system (CNS) tumors that have come back (recurrent) or does not respond to treatment (refractory). Volitinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.

Stanford is currently not accepting patients for this trial. For more information, please contact Site Public Contact, 800-694-0012.
Lead Sponsor
Stanford Investigators
- Sonia Partap
- Michelle Monje
View full details
A Pilot Study of SurVaxM in Children Progressive or Relapsed Medulloblastoma, High Grade Glioma, Ependymoma and Newly Diagnosed Diffuse Intrinsic Pontine Glioma Recruiting
More
Patients will receive a vaccine called SurVaxM on this study. While vaccines are usually thought of as ways to prevent diseases, vaccines can also be used to treat cancer. SurVaxM is designed to tell the body's immune system to look for tumor cells that express a protein called survivin and destroy them. The survivin protein can be found on up to 95% of glioblastomas and other types of cancer but is not found in normal cells. If the body's immune system knows to destroy cells that express survivin, it may help to control tumor growth and recurrence. SurVaxM will be mixed with Montanide ISA 51 before it is given. Montanide ISA 51 is an ingredient that helps create a stronger immune response in people, which helps the vaccine work better. This study has two phases: Priming and Maintenance. During the Priming Phase, patients will get one dose of SurVaxM combined with Montanide ISA 51 through a subcutaneous injection (a shot under the skin) at the start of the study and every 2 weeks for 6 weeks (for a total of 4 doses). At the same time that patients get the SurVaxM/Montanide ISA 51 injection, they will also get a second subcutaneous injection of a medicine called sargramostim. Sargramostim is given close to the SurVaxM//Montanide ISA 51 injection and works to stimulate the immune system to help the SurVaxM/Montanide ISA 51 work more effectively. If a patient completes the Priming Phase without severe side effects and his or her disease stays the same or improves, he or she can continue to the Maintenance Phase. During the Maintenance Phase, the patient will get a SurVaxM/Montanide ISA 51 dose along with a sargramostim dose about every 8 weeks for up to two years. After a patient finishes the study treatment, the doctor and study team will continue to follow his/her condition and watch for side effects up to 3 years following the last dose of SurVaxM/Montanide ISA 51. Patients will be seen in clinic every 3 months during the follow-up period.
Lead Sponsor
Stanford Investigators
- Sonia Partap
View full details
A Trial of Dabrafenib, Trametinib and Hydroxychloroquine for Patients With Recurrent LGG or HGG With a BRAF Aberration Not Recruiting
More
This phase I/II trial is designed to study the side effects, best dose and efficacy of adding hydroxychloroquine to dabrafenib and/or trametinib in children with low grade or high grade brain tumors previously treated with similar drugs that did not respond completely (progressive) or tumors that came back while receiving a similar agent (recurrent). Patients must also have specific genetic mutations including BRAF V600 mutations or BRAF fusion/duplication, with or without neurofibromatosis type 1. Neurofibromatosis type 1 is an inherited genetic condition that causes tumors to grow on nerve tissue. Hydroxychloroquine, works in different ways to stop the growth of tumor cells by killing the cells or stopping them from dividing. Trametinib and dabrafenib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Giving hydroxychloroquine with trametinib and/or dabrafenib may lower the chance of brain tumors growing or spreading compared to usual treatments.

Stanford is currently not accepting patients for this trial. For more information, please contact Michelle Monje, MD, PhD, 650-721-5750.
Lead Sponsor
Stanford Investigators
- Sonia Partap
- Michelle Monje
View full details
GD2 CAR T Cells in Diffuse Intrinsic Pontine Gliomas(DIPG) & Spinal Diffuse Midline Glioma(DMG) Recruiting
More
The primary purpose of this study is to test whether GD2-CAR T cells can be successfully made from immune cells collected from children and young adults with H3K27M-mutant diffuse intrinsic pontine glioma (DIPG) or spinal H3K27M-mutant diffuse midline glioma (DMG). H3K27Mmutant testing will occur as part of standard of care prior to enrollment.
Lead Sponsor
Stanford Investigators
View full details
Optune for Children With High-Grade Glioma or Ependymoma, and Optune With Radiation Therapy for Children With DIPG Recruiting
More
This is a multicenter trial of the Optune device to examine the feasibility and to describe the device-related toxicity in children with supratentorial high grade glioma (HGG) or ependymoma (Stratum 1) and to examine the feasibility and efficacy of concurrent Optune and standard focal radiation therapy (RT) in children with newly diagnosed diffuse intrinsic pontine glioma (DIPG) (Stratum 2).
Lead Sponsor
Stanford Investigators
- Paul Graham Fisher, MD
- Sonia Partap
View full details

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Sonia Partap

Clinical Professor, Pediatric Neurology Clinical Professor (By courtesy), Neurosurgery Clinical Professor, Pediatrics

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Sonia Partap

Clinical Professor, Pediatric Neurology Clinical Professor (By courtesy), Neurosurgery Clinical Professor, Pediatrics

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Ranjana Advani

Saul A. Rosenberg, MD, Professor of Lymphoma

Douglas W. Blayney

Professor of Medicine (Oncology), Emeritus

Gary Dahl

Professor of Pediatrics (Hematology/Oncology), Emeritus

Hisham Dahmoush

Clinical Associate Professor, Radiology - Pediatric Radiology

Sarah S. Donaldson, MD

Catharine and Howard Avery Professor in the School of Medicine, Emerita

Emma Essock-Burns

Assistant Director, Innovation Fellowship Program, School of Medicine - MDRP'S - Biodesign Program

Nancy Fischbein

Professor of Radiology and, by courtesy, of Otolaryngology - Head & Neck Surgery (OHNS), of Neurology and Neurological Sciences, of Neurosurgery & of Radiation Oncology

Paul Graham Fisher, MD

Beirne Family Professor of Pediatric Neuro-Oncology, Professor of Pediatrics and, by courtesy, of Neurosurgery and of Epidemiology and Population Health

Seunggu Jude Han, MD

Clinical Associate Professor, Neurosurgery

Steven Hancock, MD

Professor of Radiation Oncology (Radiation Therapy), Emeritus

Melanie Hayden Gephart

Professor of Neurosurgery and, by courtesy, of Neurology and Neurological Sciences

Caressa Hui

Casual - Non-Exempt, Radiation Oncology - Radiation Therapy