Mark Nicolls

Stanford University Professor of Pulmonary and Critical Care Medicine

Bio

Dr. Mark Nicolls specializes in the treatment of lung transplant patients. He has practiced pulmonary and critical care medicine for 20 years. Dr. Nicolls has a special interest in how the immune system contributes to vascular disease and has a basic science laboratory which focuses on lung transplantation, pulmonary hypertension, and lymphedema.

Clinical Focus

Pulmonary Critical Care
Lung Transplantation
Heart-Lung Transplantation
Transplantation Immunology
Pulmonary Hypertension
Pulmonary Disease
Lymphedema

Academic Appointments

Professor, Medicine - Pulmonary, Allergy & Critical Care Medicine
Member, Cardiovascular Institute
Member, CVI/Vera Moulton Wall Center
Member, Maternal & Child Health Research Institute (MCHRI)

Administrative Appointments

Director, Lung Immunology (2007 - Present)
Faculty, Vera Moulton Wall Center For Pulmonary Vascular Disease (2007 - Present)
Joint Appointment, Immunology & Rheumatology (2007 - Present)
Member, Institute for Immunity, Transplantation and Infection (2007 - Present)
Member, Stanford Cardiovascular Institute (2007 - Present)
Program Director, Pulmonary and Critical Care Fellowship (2009 - 2010)
Chief, Pulmonary, Allergy and Critical Care Medicine (2010 - Present)
Chairman of the Board, Palo Alto Veterans Administration Institute for Research (2015 - 2021)
Medical Director, Pulmonary, Allergy & Critical Care Medicine Service Line, Stanford Health Care (2018 - Present)
Associate Dean for Research, Stanford University School of Medicine (2023 - Present)

Honors & Awards

Elected Member, The American Society for Clinical Investigation (2014-)
Endowed Chair, The Stanford Professor of Pulmonary and Critical Care Medicine, Stanford University (2016-)
Elected Member, Association of American Physicians (2020-)
Dickinson Richards Lecture, American Heart Association (2021)

Boards, Advisory Committees, Professional Organizations

Executive Committee, Stanford Cardiovascular Institute (2010 - Present)
Steering Committee - Vera Moulton Wall Center for Pulmonary Vascular Disease, Stanford University School of Medicine (2007 - Present)

Professional Education

Board Certification: American Board of Internal Medicine, Pulmonary Disease (1998)
Fellowship: University of Colorado School of Medicine (1999) CO
Residency: Stanford University School of Medicine (1996) CA
Medical Education: Stanford University School of Medicine (1993) CA
Board Certification, ABIM, Critical Care Medicine (1999)
BS, University of Portland, Biology (1987)

Patents

Mark Nicolls, Gregg Semenza, Xinguo Jiang, Gundeep Dhillon, Jayakumar Rajadas, Geoffrey Gurtner. "United States Patent 10548860 HIF-1 modulator paint formation and uses thereof", Leland Stanford Junior University, VA Palo Alto, Johns Hopkins, Feb 4, 2020
Preetha Jothimuthu, Mohammed Inayathullah Nazir Ahmed, Wen A. Tian, Jayakumar Rajadas, Mark Nicolls, JooChuan Ang. "United States Patent 10527577 Nanogrid electrochemical sensor for detection of biochemical species by electrochemical impedance spectroscopy", The Board of Trustees of the Leland Stanford Junior University, The United States of America as represented by the Department of Veteran Affairs (Washington DC), Jan 7, 2020
Mark Nicolls, Stanley G. Rockson, Wen A. Tian, Xinguo Jiang, Jeanna Kim. "United States Patent 10500178 LTB4 inhibition to prevent and treat lymphedema", The Board of Trustees of the Leland Stanford Junior University, Dec 10, 2019
Mark Nicolls, Gregg Semenza, Xinguo Jiang, Gundeep Dhillon, Jayakumar Rajadas, Geoffrey Gurtner,. "United States Patent 10,220,009 HIF-1 Modulator Paint Formulation and Uses Thereof", Leland Stanford Junior University, VA, Johns Hopkins, Mar 5, 2019
Mark Nicolls, Wen Tian, Jayakumar Rajadas. "United States Patent 9861601 Treatment of pulmonary arterial hypertension with leukotriene inhibitors.", Leland Stanford Junior University, VA Palo Alto, Jan 9, 2018
Mark Nicolls, Xinguo Jiang, Geoffrey Gurtner, Gregg Semenza, Jayakumar Rajadas. "United States Patent 9763899 Iron chelators and use thereof for reducing transplant failure during rejection episodes.", Leland Stanford Junior University, VA, Johns Hopkins, Sep 19, 2017
Mark Nicolls, Karl Kossen, Alan Cohen. "United States Patent 9682071 Methods for improving microvascular integrity.", Leland Stanford Junior University, Intermune Inc., Jun 20, 2017
Mark Nicolls, Wen Tian, Jayakumar Rajadas. "United States Patent 9233089 Treatment of pulmonary hypertension with leukotriene inhibitors.", Leland Stanford Junior University, Jan 12, 2016

Contact

Academic mnicolls@stanford.edu

Administrative Contact Yvette Sanchez Administrative Associate yvette88@stanford.edu Tel: 650-721-3068

Clinical (Primary)

This is the primary clinic for this clinical provider. For additional clinical locations and information, please visit the link(s) listed below in the 'Additional Clinical Info' section.

Chest Clinic 300 Pasteur Dr Rm A157 MC 5351 Stanford CA 94305 Tel: (650) 725-7061 Fax: (650) 498-6288

Additional Clinical Info

Stanford Health Care

Current Research and Scholarly Interests

Our lab focuses primarily on the contribution of the immune response to lung disease. We are specifically examining the contribution of inflammation to the development of vascular injury in transplantation, pulmonary hypertension and lymphedema.

Clinical Trials

Trial of Acebilustat for the Treatment of Upper Arm Lymphedema Recruiting
More
This study is designed to investigate the response of unilateral upper extremity (arm) lymphedema, during pharmacologic treatment of lymphedema with oral placebo and oral acebilustat. Participants will receive "study drug" (Acebilustat or placebo), for 9 months. For 3 of these months, the participant will receive placebo; for 6 of these months, the participant will receive active ingredient, acebilustat. The study is blinded which means that the participant will not be told which study pill they are taking.

Lead Sponsor
- Stanford University
Stanford Investigators
- Mark Nicolls
- Stanley G. Rockson, MD
View full details
Rituximab for Treatment of Systemic Sclerosis-Associated Pulmonary Arterial Hypertension (SSc-PAH) Not Recruiting
More
Systemic sclerosis-associated pulmonary arterial hypertension (SSc-PAH) is a serious, life-threatening manifestation of systemic sclerosis (SSc), an autoimmune disease of the connective tissue characterized by scarring (fibrosis) and atrophy of the skin, joints and tendons, skeletal muscles, and internal organs, and immunological disturbances. One-year survival for patients with SSc-PAH ranges from 50-81%. There is currently no cure for SSc-PAH and treatment is limited to vasodilator therapy used in all forms of PAH. In recent studies, immunotherapy was shown to be effective in treating SSc-interstitial lung disease, another serious, life-threatening manifestation of SSc. In addition, there are compelling pre-clinical data and anecdotal clinical reports that suggest modulation of the immune system may be an effective strategy for treating SSc-PAH. To test this approach, this trial will determine if rituximab, an immunotherapy, has a marked beneficial effect on clinical disease progression, with minimal toxicity, in patients with SSc-PAH when compared to placebo.

Stanford is currently not accepting patients for this trial. For more information, please contact Val Scott, 650-725-8082.
Lead Sponsor
Stanford Investigators
View full details

2023-24 Courses

Independent Studies
- Directed Reading in Immunology
  IMMUNOL 299 (Aut, Win, Spr, Sum)
- Directed Reading in Medicine
  MED 299 (Aut, Win, Spr, Sum)
- Early Clinical Experience in Immunology
  IMMUNOL 280 (Aut, Win, Spr, Sum)
- Early Clinical Experience in Medicine
  MED 280 (Aut, Win, Spr, Sum)
- Graduate Research
  IMMUNOL 399 (Aut, Win, Spr, Sum)
- Graduate Research
  MED 399 (Aut, Win, Spr, Sum)
- Medical Scholars Research
  MED 370 (Aut, Win, Spr, Sum)
- Teaching in Immunology
  IMMUNOL 290 (Aut, Win, Spr, Sum)
- Undergraduate Research
  IMMUNOL 199 (Aut, Win, Spr, Sum)
- Undergraduate Research
  MED 199 (Aut, Win, Spr, Sum)

Stanford Advisees

Postdoctoral Faculty Sponsor
Layla Barkal, Dongeon Kim, Seunghee Lee, Eric Sumner
Postdoctoral Research Mentor
Dongeon Kim

Graduate and Fellowship Programs

Immunology (Phd Program)

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