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Dr. Vinicio de Jesus Perez received his MD from the University of Puerto Rico Medical School and completed an internal medicine residency at Massachusetts General Hospital. He completed a fellowship in pulmonary and critical care medicine in Denver, followed by postdoctoral research training at Stanford University. He focused on researching genetic and molecular mechanisms of pulmonary hypertension (PH) and idiopathic pulmonary fibrosis (IPF) and has devoted his clinical practice to diagnosis and management of these conditions. He is presently associate professor of medicine and staff physician of the Stanford Adult PH Clinic where he trains fellows pursuing careers in PH and IPF. He is principal investigator of a research program with the ultimate goal of identifying new therapeutic targets to treat PH and IPF. As a medical professional belonging to a minority group, Dr. de Jesus Perez is involved in academic endeavors seeking to improve access of care for patients with disadvantageous ethnic backgrounds and promote diversity in medicine.
The goal of this project is to compare the genetic data obtained from whole exome sequencing (WES) of our PAH population at Stanford with that of a large (>100) cohort of patients in Spain. This rich dataset includes patients with both inherited and sporadic forms of PAH and has allowed us to identify novel candidate genes that could reflect the involvement of novel signaling pathways in the pathobiology of PAH.
This projects looks at the role of versican in the pathogenesis of pulmonary vascular remodeling associated with PAH.
This collaboration aims to connect physicians from the USA and Puerto Rico to share models of education in pulmonary vascular medicine that will benefit both students and seasoned practitioners.
san juan, puerto rico
This collaboration aims to combine the information obtained from transcriptome analysis with protein analysis via liquid chromatography/mass spectrometry (LC/MS) to identify novel modifiers in fibroblasts and smooth muscle cells isolated from patients with PAH.
Mentoring Women Scientists
Women and minorities
Pulmonary Hypertension Association
Latin-american PH patients
Patientsd and families with PH
My work is aimed at understanding the molecular mechanisms involved in the development and progression of pulmonary arterial hypertension (PAH). I am interested in understanding the role that the BMP and Wnt pathways play in regulating functions of pulmonary endothelial and smooth muscle cells both in health and disease.
Utility of At-home Monitoring of Exercise Capacity by App-based 6-minute Walk Test
- Evaluate for accuracy and reproducibility of data collected via the participant-operated
Walk.Talk.Track. (WTT) app combined with Apple Watch during in-clinic, technician
- Determine whether the WTT app on the Apple Watch can accurately collect information
on distance traveled and heart rate (HR) during in-clinic 6MWT run by American
Thoracic Society (ATS) guidelines
- Determine whether participants can operate the WTT app and Apple Watch effectively
to gather accurate data in a monitored and home-based setting
- Prospectively monitor for changes in WTT app recorded 6MWT results following initiation
of therapy in a treatment naïve cohort of PAH participants
- Evaluate whether changes from baseline in 6 minute walk distance (6MWD) and heart
rate recovery at one minute (HRR1) as well as other variables that have been
associated with disease severity in PAH and left-sided heart disease (resting HR,
heart rate variability [HRV], chronotropic index [CI]) can be identified before the
12-week follow up when comparing the treatment arm and the control arm
- Evaluate whether changes from baseline in the HRR1, resting HR, HRV and/or CI are
more evident in treatment responders when compared to treatment non-responders.
Stanford is currently not accepting patients for this trial.
For more information, please contact Alejandra Elizabeth Lopez, 650-725-4000.
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