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There are two major areas of focus in the laboratory. First, we are interested in Epstein Barr Virus-mediated mechanisms of immune evasion with particular focus on pathways that promote survival and proliferation of EBV B cell lymphomas, the characterization of the human T cell response to EBV-infected B cells and the identification of novel therapeutics for treatment of EBV B cell lymphomas. The second area of study addresses stem cell and solid organ transplantation. In particular we are examining mechanisms of graft rejection and immune regulation in allogeneic responses.
COVID-19: Pediatric Research Immune Network on SARS-CoV-2 and MIS-C
The primary objectives of this study are:
- To determine the proportion of children with Severe Acute Respiratory Syndrome
Coronavirus 2 (SARS-CoV-2) related death, rehospitalization or major complications after
infection with SARS-CoV-2 and/or Multisystem Inflammatory Syndrome in Children (MIS-C),
- To determine immunologic mechanisms and immune signatures associated with disease
spectrum and subsequent clinical course during the year of follow-up.
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Biomarkers for Post-Transplant Lymphoproliferative Disorders in Children
Solid organ transplantation is an important therapeutic option for children with a variety of
end stage diseases. However, the same immunosuppressive medications that are required to
prevent the child's immune system from attacking and rejecting the transplanted organ can
predispose these individuals to developing a very serious cancer that is linked to
Epstein-Barr virus (EBV).
Stanford is currently not accepting patients for this trial.
For more information, please contact Sheri Krams, PhD, 650-498-6246.