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Frank L. Hanley, MD, is a professor of cardiothoracic surgery and director of the Childrens Heart Center and also directs the pediatric cardiac surgery programs at three satellite surgical sitesOakland Childrens Hospital of Central California in Madera and Sutter Memorial Hospital in Sacramentomaking the expertise of Lucile Packard Childrens Hospital available to these communities. His research and clinical work focuses on the development of interventional techniques for fetal and neonatal treatment of congenital heart disease, pulmonary, vascular physiology, and the neurologic impact of open-heart surgery. He developed and pioneered the unifocalization procedure, in which a single procedure is used to repair a complex and life-threatening congenital heart defect rather than several staged open-heart surgeries as performed by other surgeons. Currently, Lucile Packard Childrens Hospital is a worldwide referral site for patients requiring these procedures.Hanley earned his BA from Brown University and his MD from Tufts University School of Medicine. He completed a surgical internship at the University of California, San Francisco (UCSF), where he later became chief resident in both general surgery and cardiothoracic surgery and completed a research fellowship at UCSFs Cardiovascular Research Institute. Hanley was a tenured professor and chief of the Division of Cardiothoracic Surgery at UCSF and received the Excellence in Teaching Award in the Department of Surgery in 1994. Prior to joining UCSF, he was on the faculty at Childrens Hospital Boston and served as associate professor at Harvard Medical School from 1989 to 1992. He joined the Stanford faculty in 2001 and was appointed the first holder of the Lawrence Crowley, MD, Endowed Professorship in Child Health in December 2004.Hanley is actively involved in exploring new approaches for the surgical repair of pediatric heart disease and is developing evidence-based guidelines for clinical care. He is a member of many professional societies, including the American Heart Association, the American Association for Thoracic Surgery, the Howard C. Naffziger Surgical Society, and the Society of Thoracic Surgeons. He is a frequently invited guest lecturer, having given more than 75 presentations at regional, national, and international conferences and symposiums, and having published more than 100 peer-reviewed articles and book chapters, and authored or edited three major textbooks.
Measuring the Amount of Methadone or Morphine in the Blood of Neonates, Infants & Children After Cardiac Surgery.
Neonates, infants and children from birth to 5 years of age undergoing cardiac surgery with
The use of methadone to provide analgesia may be increasing due to advantages compared to
other commonly used opioid analgesic drugs. While efficacy of methadone has been reported in
adults, there is a paucity of information in neonates and infants. In the latter population,
fentanyl and morphine are most commonly used for opioid analgesia following major surgery,
while methadone is frequently used for weaning of opioid dependent and tolerant patients, in
spite of the paucity of knowledge of methadone pharmacology in this population. There are
several clinical problems associated with fentanyl and morphine, and methadone may offer
superior efficacy with fewer side effects than these agents. We propose to study the
pharmacokinetics (PK) and pharmacodynamics (PD) of methadone in neonates and infants in the
intensive care unit following cardiac surgery.
Stanford is currently not accepting patients for this trial.
For more information, please contact Gregory Hammer, 6507237835.
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