Yan Gao

Basic Life Science Research Scientist, OHNS/Research Division

All Publications

Publications (8)

All Publications (8)
Journal Articles (8)

Profiles With Related Publications

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Jeffrey Axelrod

Professor of Pathology
Research Interests
Genetic and cell biological analyses of signals controlling cell polarity and morphogenesis. Frizzled signaling and cytoskeletal organization.

95 Total Publications
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Debadrita Bhattacharya

Postdoctoral Scholar, Hematology-Oncology

9 Total Publications
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Alistair Boettiger

Assistant Professor of Developmental Biology
Research Interests
My lab focuses on investigating the role of three-dimensional genome organization in regulating gene expression and in shaping cell fate specification during development. We pursue this with advanced single-molecule imaging and transgenics.

46 Total Publications
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Anne Brunet

Michele and Timothy Barakett Endowed Professor
Research Interests
Our lab studies the molecular basis of longevity. We are interested in the mechanism of action of known longevity genes, including FOXO and SIRT, in the mammalian nervous system. We are particularly interested in the role of these longevity genes in neural stem cells. We are also discovering novel genes and processes involved in aging using two short-lived model systems, the invertebrate C. elegans and an extremely short-lived vertebrate, the African killifish N. furzeri.

155 Total Publications
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James K. Chen

Jauch Professor and Professor of Chemical and Systems Biology, of Developmental Biology and of Chemistry
Research Interests
Our laboratory combines chemistry and developmental biology to investigate the molecular events that regulate embryonic patterning, tissue regeneration, and tumorigenesis. We are currently using genetic and small-molecule approaches to study the molecular mechanisms of Hedgehog signaling, and we are developing chemical technologies to perturb and observe the genetic programs that underlie vertebrate development.

90 Total Publications
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Paul Cheng MD PhD

Assistant Professor of Medicine (Cardiovascular Medicine)
Clinical Focus
Amyloidosis, Cardio-Oncology, Cardiovascular Disease

44 Total Publications
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Karlene Cimprich

Professor of Chemical and Systems Biology and, by courtesy, of Biochemistry
Research Interests
Genomic instability contributes to many diseases, but it also underlies many natural processes. The Cimprich lab is focused on understanding how mammalian cells maintain genomic stability in the context of DNA replication stress and DNA damage. We are interested in the molecular mechanisms underlying the cellular response to replication stress and DNA damage as well as the links between DNA damage and replication stress to human disease.

75 Total Publications
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Pablo Domizi, Ph.D.

Instructor, Pediatrics - Hematology & Oncology
Research Interests
Understanding phenotypic flexibility in B-cell ALL and its impact on CAR-T therapy success. Integration of single cell RNA and protein expression data to build models to predict patients at risk of Antigen Loss relapse after CAR-T cell immunotherapies.

27 Total Publications
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James Ferrell

Professor of Chemical and Systems Biology and of Biochemistry
Research Interests
My lab has two main goals: to understand the regulation of mitosis and to understand the systems-level logic of simple signaling circuits. We often make use of Xenopus laevis oocytes, eggs, and cell-free extracts for both sorts of study. We also carry out single-cell fluorescence imaging studies on mammalian cell lines. Our experimental work is complemented by computational and theoretical studies aimed at understanding the design principles and recurring themes of regulatory circuits.

152 Total Publications
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Casey Gifford

Assistant Professor of Pediatrics (Cardiology) and of Genetics

29 Total Publications
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Or Gozani

Dr. Morris Herzstein Professor
Research Interests
We study the molecular mechanisms by which chromatin-signaling networks effect nuclear and epigenetic programs, and how dysregulation of these pathways leads to disease. Our work centers on the biology of lysine methylation, a principal chromatin-regulatory mechanism that directs epigenetic processes. We study how lysine methylation events are generated, sensed, and transduced, and how these chemical marks integrate with other nuclear signaling systems to govern diverse cellular functions.

122 Total Publications
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Sherril L. Green, DVM, PhD

Professor of Comparative Medicine, Emerita
Research Interests
Research Interests: Xenopus laevis. Husbandry, biology, infectious and parasitic diseases of laboratory Xenopus laevis. Large animal models of disease.

27 Total Publications