Wei Jiang

Instructor, Pediatrics - Human Gene Therapy

Academic Appointments

Instructor, Pediatrics - Human Gene Therapy

Honors & Awards

Senior Postdoctoral Research Award, Novo Nordisk, Inc. (2015-2017)
CHRI Fellowship, Lucile Packard Foundation for Children’s Health (2011, 2013)
Graduate Student Achievement Award, 3rd Annual Comparative & Experimental Medicine and Public Health Research Symposium (2009)

Boards, Advisory Committees, Professional Organizations

Associated Faculty Member, Faculty of 1000 Prime (2012 - Present)

Professional Education

Ph.D., University of Pennsylvania, Chemical and Biomolecular Engineering (2010)
B.S., Tsinghua University, Chemical and Biomolecular Engineering (2004)

Current Research and Scholarly Interests

I have a particular interest in MHC-II antigen presentation and MHC-II-associated autoimmunity that are linked to environmental triggers. Relevant diseases include narcolepsy, celiac disease, influenza infection and COVID-19. Given multidisciplinary background, I also have developed high throughput engineering tools to advance diagnosis and/or treatment of these diseases.
Projects include:
•To study DO/DM regulated MHC-II antigen presentation in relevant to T cell-B cell immunity.
•To study MHC-II-restricted CD4+ T cells cross-reactive with self-protein and viral antigen (i.e., derived from the H1N1 influenza virus or the SARS-CoV-2 virus).
•To develop T cell receptor mimics for identification of gluten presenting cells in celiac disease.
•To develop high throughput yeast display system for MHC-II ligand identification.

All Publications

Profiles With Related Publications

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Christopher O. Barnes

Assistant Professor of Biology and, by courtesy, of Structural Biology

25 Total Publications
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Steven Boxer

Camille Dreyfus Professor of Chemistry
Research Interests
Please visit my website for complete information:
http://www.stanford.edu/group/boxer/

456 Total Publications
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Axel Brunger

Professor of Molecular and Cellular Physiology, of Neurology, of Photon Science and, by courtesy, of Structural Biology
Research Interests
One of Axel Brunger's major goals is to decipher the molecular mechanisms of synaptic neurotransmitter release by conducting imaging and single-molecule/particle reconstitution experiments, combined with near-atomic resolution structural studies of the synaptic vesicle fusion machinery.

167 Total Publications
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Rohini Datta

Postdoctoral Scholar, Genetics

5 Total Publications
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Jiayi Dou

Postdoctoral Scholar, Bioengineering

7 Total Publications
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Ron Dror

Associate Professor of Computer Science and, by courtesy, of Molecular and Cellular Physiology and of Structural Biology

121 Total Publications
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C. Garrison Fathman

Professor of Medicine (Immunology and Rheumatology), Emeritus
Research Interests
My lab of molecular and cellular immunology is interested in research in the general field of T cell activation and autoimmunity. We have identified and characterized a gene (GRAIL) that seems to control regulatory T cell (Treg) responsiveness by inhibiting the Treg IL-2 receptor desensitization. We have characterized a gene (Deaf1) that plays a major role in peripheral tolerance in T1D. Using PBC gene expression, we have provisionally identified a signature of risk and progression in T1D.

324 Total Publications
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Chris Garcia

Younger Family Professor and Professor of Structural Biology
Research Interests
Structural and functional studies of transmembrane receptor interactions with their ligands in systems relevant to human health and disease - primarily in immunity, infection, and neurobiology. We study these problems using protein engineering, structural, biochemical, and combinatorial biology approaches.

244 Total Publications
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Pehr Harbury

Associate Professor of Biochemistry
Research Interests
Scientific breakthroughs often come on the heels of technological advances; advances that expose hidden truths of nature, and provide tools for engineering the world around us. Examples include the telescope (heliocentrism), the Michelson interferometer (relativity) and recombinant DNA (molecular evolution). Our lab explores innovative experimental approaches to problems in molecular biochemistry, focusing on technologies with the potential for broad impact.

58 Total Publications
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Possu Huang

Assistant Professor of Bioengineering

48 Total Publications
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Ted Jardetzky

Professor of Structural Biology
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The Jardetzky laboratory is studying the structures and mechanisms of macromolecular complexes important in viral pathogenesis, allergic hypersensitivities and the regulation of cellular growth and differentiation, with an interest in uncovering novel conceptual approaches to intervening in disease processes. Ongoing research projects include studies of paramyxovirus and herpesvirus entry mechanisms, IgE-receptor structure and function and TGF-beta ligand signaling pathways.

185 Total Publications
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Patricia Jones

The Dr. Nancy Chang Professor, Emerita
Research Interests
Dr. Jones' research has focused on genetic, molecular, and cellular mechanisms that regulate immune responses. Recent work was centered on the regulation of innate immune responses that are triggered by conserved microbial components. As these responses can be harmful they are highly regulated in their occurrence, magnitude, and duration. Her lab discovered a novel mechanism that negatively regulates innate responses, mediated by the phosphatase calcineurin.

31 Total Publications