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New medications help many people with inflammatory conditions and may ease severe COVID-19, but they carry risks.
The director of the Center for Innovation in Global Health explains how the medical community is at the center of the climate change debate.
Stanford researchers have developed a synthetic, tumor-targeting molecule that promotes immune activation and tumor regression in laboratory mice after it’s injected into their bloodstreams.
A potential COVID-19 vaccine, delivered via a squirt up the nose, shows promise in mice.
Kelsey was known for her teaching skills, her expertise in musculoskeletal disorders and her love of golden retrievers.
Wyss-Coray and his collaborators are working to discover the specific factors in the blood of young mice that can recharge the brain of an old mouse.
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Michael Greicius and his team have found that women who carry a copy of a gene variant called ApoE4 have a substantially greater risk of developing Alzheimer's.
Research led by immunologist Kari Nadeau shows a blood test could determine whether patients who have been desensitized to their peanut allergies need to continue eating peanuts daily to retain their tolerance.
Bioengineer Karl Deisseroth develops CLARITY, a process that renders brain tissue from mice transparent, allowing the entire brain structure and its wiring to be studied.
An in-vitro activation procedure developed by endocrinologist Aaron Hsueh is used to induce egg growth in some infertile women, and one gives birth.
Geneticist Michael Snyder integrates a deep analysis of his DNA, RNA and the proteins in his cells; the analysis correctly predicts that he will develop diabetes.
Pathologist Irving Weissman shows that a single antibody, which counters the effect of the CD47 molecule, shrinks a variety of human tumors transplanted into mice.
Bioengineer Stephen Quake develops a groundbreaking method to sequence the genome of an unborn baby using only a blood sample from the mother.
Using skin cells from patients with a severe genetic heart defect, neurobiologist Ricardo Dolmetsch creates human heart cells with the same genetic mutation, allowing his team to test drugs on the cells.
Bioengineer Karl Deisseroth uses the optogenetic technique in mice to switch on and off the social-behavior deficits that resemble those in humans with autism and schizophrenia.
Studies by Marina Sirota, Joel Dudley and Atul Butte demonstrate an approach that could quicken the pace of combating difficult diseases by matching them with drugs that are already approved for other indications.
Physicians at Lucile Packard Children's Hospital Stanford use aggregate patient data from electronic medical records to identify the best option for treating a patient with rare disorder.
Pathologist Marius Wernig turns mouse skin cells into cells that insulate neurons with the application of just three genes.
A team of researchers analyzes bioengineer Stephen Quake's genome, predicting his likelihood of developing heart disease, Alzheimer's and cancer.
A team of researchers led by Irving Weissman discovers that leukemia stem cells evade detection by mimicking normal cells and moving safely within the body.
Pathologist Irving Weissman identifies the stem cell that gives rise to bladder cancer, and also shows how the cell uses the "don't-eat-me" signal, a molecule known as CD47, to evade the body's defenses.
A technique developed by bioengineer Stephen Quake enables him to sequencs his own genome for less than $50,000 and with a team of just two others.
Bioenginner Stephen Quake and his team develop a method of screening a pregnant woman's blood to identify chromosomal disorders, such as Down syndrome, in her fetus.
Radiologist Sanjiv Gambhir develops a new type of imaging system that can illuminate tumors in living subjects with a precision of nearly one-trillionth of a meter
Radiation oncologist Amato Giaccia identifies a molecule that kills kidney cancer cells, which could provide new treatment options.
Pediatric nephrologist Minnie Sarwal finds that kidney transplant recipients with a similar gene-expression pattern were able to eliminate or reduce their dependence on immunosuppressive drugs.
Bioengineer Karl Deisseroth and his team develop a technique known as optogenetics that allows them to genetically alter brain cell activity in mice with light.
Neurosurgeon Gary Steinberg tracks human stem cells transplated into brain of rats, finding that they successfully navigate toward areas damaged by stroke.
Radiation oncologist Amato Giaccia identifies a protein called lysyl oxidase that, when found in a low-oxygen environment, may cause fast-spreading cancers.
Endocrinologist Aaron Hsueh discovers obestatin, a hormone that supresses appetite and may lead to treatments for obesity.
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Developmental biologist Roeland Nusse isolates a group of proteins called Wnts that help keep stem cells in their youthful state.
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Geneticist Mark Kay uses a gene-therapy technique known as RNA inihibition to switch off genes in mice, which could point toward development treatments for cancer, hepatitis C and AIDS.
In a study in mice, researcher Rosemarie DeKruyff identifies a gene family that may underlie the development of asthma.
Teams headed by geneticist Richard Myers and biochemist Ronald Davis help sequence the human genome.
Developmental biologist David Kingsley discovers that a gene that transports pyrophosphate into cells may regulate the development of arthritis in humans and animals.
Structural biologist Roger Kornberg shows the structure of the RNA polymerase protein, a step in the transfer of information from gene to protein. The discovery will later earn Kornberg the 2006 Nobel Prize in Chemistry.
Sleep researcher Emmanuel Mignot identifies the defective gene that causes narcolepsy, a disabling sleep disorder affecting humans and animals.
Pediatrician Thomas Robinson finds that children who curtailed their television time gained significantly less body fat than those who didn't .
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Pediatric oncologist Michael Link leads a study that shows chemotherapy can be reduced by two-thirds in children with early-stage non-Hodgkin's lymphoma with no negative consequences.
Christopher Contag develops a technique to detect light emitted when certain genes are activated in a living animal model.
Developmental biologist Matthew Scott and a team at UC-San Francisco discover that a defect in the hedgehog gene causes basal cell carcinoma.
Oncologist Amato Giaccia and his colleagues find that the p53 protein, known to be involved in controlling cancerous tumors, can help halt cancer development.
Read more about Dr. Amato Giaccia (PDF)
Christpher Contag and David Benaron develop optical imaging that allows researchers to detect and track bioluminescent bacteria in mice.
Biochemist Pat Brown and colleagues develop microarrays, or gene chips, that allow researchers to analyze the activity of thousands of genes in a cell at once.
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Neonatologist David Stevenson develops a diagnostic instrument that provides rapid bedside screening for the breakdown of red blood cells in jaundiced newborns.
Pathologist Gerald Crabtree develops techniques that allow scientists to toggle genes on and off in animal models.
Researcher William Haskell shows that intensive lifestyle changes and prevention/treatment programs can reduce cardiac events and slow the progression of atherosclerosis in coronary arteries.
Researchers Joel Killen and Thomas Robinson publish findings that shed light on the causes of eating disorders in adolescents.
Researchers produce the first functional image using time-resolved, near-infrared light.
Neurobiologist Eric Shooter finds a gene involved in nerve disorders in which the protective covering on nerves breaks down.
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Oncologist Ron Levy develops a cancer vaccine that could prevent recurrrent lymphomas in patients treated with chemotherapy.
Biochemist Arthur Kornberg finds a chemical impulse that turns off the reproductive machinery in the chromosomes of E. coli bacteria.
Pathologist Eugene Butcher discovers a receptor that guides white blood cells into the peripheral lymph nodes.
Researchers Irving Weissman and Mike McCune create an animal model that can be used to study a variety of human diseases.
Pathologist Irving Weissman isolates a rare mouse cell, known as the hematopoetic stem cell, which gives rise to all the cells of the blood and immune systems.
Immunologist Mark Davis characterizes the T-cell receptor, believed to regulate the body's response to infectious agents and cancerous diseases.
More about Dr. Mark Davis (PDF)
Stanford's Henry Kaplan and Nelson Teng and colleagues at UC-San Diego develop the first human monoclonal antibody for treating overwhelming infections.
Oncologist Ronald Levy reports the first successful use of monoclonal antibodies, which are laboratory-created molecules engineered to attach to specific defects in cancer cells.
Mary Gohlke receives the world's first combined heart and lung transplant in a landmark operation led by surgeon Bruce Reitz.
Henry Kaplan and Lennart Olsson create cells to manufacture human antibodies for the improved diagnosis and treatment of diseases.
Pharmacologist Avram Goldstein discovers a chemical in the human brain that could lead to the development of powerful painkillers with fewer undesirable side effects.
John Farquhar and Peter Wood demonstrate that exercise is associated with an increase in "good" cholesterol levels, and can decrease the likelihood of coronary problems.
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