2024
- Komankova L, Broz A, Hlidkova H, Hodan J, Krumbholcova EC, Bacakova L, Pratx G, Hruby M, Vetrik M, “Polyacrylonitrile‒Chitosan IPN composite scaffolds that closely mimic the human trabecular bone structure for tissue engineering,” Materials Today Chemistry 40 102253
- Nguyen HTM, Das N, Ricks M, Zhong X, Takematsu E, Yuting W, Ruvalcaba C, Roncali E, Chan CKF & Pratx G, "Ultrasensitive and multiplexed tracking of single cells using whole-body PET/CT," Sci. Adv. 10(24) eadk5747
- Das N, Nguyen HTM, Lu WJ, Natarajan A, Khan S & Pratx G, “Increased [18F]FDG Uptake of Radiation-Induced Giant Cells: A Single-Cell Study in Lung Cancer Models,” npj Imaging 2(14)
2023
- Jung KO & Pratx G, "Single-Cell PET Imaging and Tracking," In: Witney TH, Shuhendler AJ, eds. Positron Emission Tomography: Methods and Protocols. Methods in Molecular Biology, Springer; pp. 331-340
- Natarajan A, Khan S, Liang X, Nguyen H, Das N, Anders D, Malik N, Oderinde OM, Chin FT, Rosenthal EL & Pratx G, “Preclinical evaluation of 89Zr-Panitumumab for biology-guided radiotheraphy," Int. J. Radiat. Oncol. Biol. Phys. 116(4), pp. 927-934
- Liu Z, Nguyen HTM, Asanuma D, Tojo S, Yamaji M, Kawai K, Pratx G, Fujitsuka M & Osakada Y, “Red, green, and blue radio-luminescent polymer dots doped with heteroleptic tris-cyclometalated iridium complexes,” RSC Adv. 13(22), pp.15126-15131
- Asanuma D, Nguyen HTM, Liu Z, Tojo S, Shigemitsu H, Yamaji M, Kawai K, Mori T, Kida T, Pratx G, Fujitsuka M & Osakada Y “Radioluminescence from polymer dots based on thermally activated delayed fluorescence,” Nanoscale Adv. 5(13), pp. 3424-3427
2022
- Ha B, Liang K, Liu C, Melemenidis S, Manjappa R, Viswanathan V, Das N, Ashraf R, Lau B, Soto S, Graves EE, Rao J, Loo BW, and Pratx G, “Real-time optical oximetry during FLASH radiotherapy using a phosphorescent nanoprobe,” Radiother. Oncol. 176, pp. 239-243
- Jung KO, Theruvath AJ, Nejadnik H, Liu A, Xing L, Sulchek T, Daldrup-Link HE & Pratx G, “Mechanoporation enables rapid and efficient radiolabeling of stem cells for PET imaging,” Sci. Rep. 12, pp. 2955
- Vetrik M, Kucka J, Kobera L, Konefal R, Lobaz V, Pavlova E, Bajecny M, Heizer T, Brus J, Sefc L, Pratx G & Hruby M, “Fluorinated diselenide nanoparticles for radiosensitizing therapy of cancer,” Free Radic. Biol. Med. 187, pp. 132-140
- Cui S & Pratx G, “3D computational model of oxygen depletion kinetics in brain vasculature during FLASH RT and its implications for in vivo oximetry experiments,” Med. Phys. 49(6), pp. 3914-3925
- Gao H, Liu J, Lin Y, Gan GN, Pratx G, Wang F, Langen K, Bradley JD, Rotondo RL, Li HH & Chen RC, “Simultaneous dose and dose rate optimization (SDDRO) of the FLASH effect for pencil-beam-scanning proton therapy,” Medical Physics 49(3), pp. 2014-2025
- Klein JS, Kim TJ & Pratx G, “Development of a lensless radiomicroscope for cellular-resolution radionuclide imaging,” J. Nucl. Med.
2021
- Khan S, Shin JH, Ferri V, Cheng N, Noel JE, Kuo C, Sunwoo JB & Pratx G, "High-resolution positron emission microscopy of patient-derived tumor organoids," Nat. Communications 12, pp. 5883
- Ha B, Kim TJ, Moon EJ, Giaccia AJ & Pratx G, "Flow Radiocytometry Using Droplet Optofluidics," Biosens. Bioelectron. 194, pp. 113565
- Kim TJ, Ha B, Bick AD, Kim M, Tang SKY & Pratx G, “Microfluidics-Coupled Radioluminescence Microscopy for In Vitro Radiotracer Kinetic Studies," Anal. Chem. 93 (10), pp. 4425-4433
- Khan S, Bassenne M, Wang J, Manjappa R, Melemenidis S, Breitkreutz DY, Maxim PG, Xing L, Loo BW, & Pratx G, “Multicellular spheroids as in vitro models of oxygen depletion during FLASH irradiation,” Int. J. Radiat. Oncol. Biol. Phys. 110(3), pp. 833-844
- Khan S, Kim S, Yang YP & Pratx G, "High-resolution radioluminescence microscopy of FDG uptake in an engineered 3D tumor-stoma model," Eur. J. Nuc. Med. Mol. Imaging 48(11), 3400-3407
- Windows-Yule CRK, Herald M, Nicusan L, Wiggins C, Pratx G, Manger S, Odo EA, Leadbeater T, Pellico J, de Rosales R, Renaud A, Govender I, Carasik L, Ruggles A, Kokalova-Wheldon T, Seville J & Parker DJ, "Recent Advances in Positron Emission Particle Tracking: A Comparative Review," Rep Prog Phys. 85, pp. 016101
- Yu JH, Steinberg I, Davis R, Malkovskiy A, Zlitni A, Radzyminski RK, Jung KO, Chung D, Curet LD, Souza A, Chang E, Rosenberg J, Campbell J, Frostig H, Park SM, Pratx G, Levin CS & Gambhir SS, “Noninvasive and Highly Multiplexed Five-Color Tumor Imaging of Near-Infrared Resonant Surface-Enhanced Raman Nanoparticles In Vivo,” ACS Nano 15 (12), pp. 19956-19969
2020
- Jung KO, Kim YH, Chung SJ, Lee CH, Rhee S, Pratx G, Chung JK & Youn H, “Identification of Lymphatic and Hematogenous Routes of Rapidly Labeled Radioactive and Fluorescent Exosomes through Highly Sensitive Multimodal Imaging,” Int. J. Mol. Sci. 21(21), pp.7850
- Ren Y, Rosch JG, Landry MR, Winter H, Khan S, Pratx G & Sun C, “Tb-Doped core–shell–shell nanophosphors for enhanced X-ray induced luminescence and sensitization of radiodynamic therapy,” Biomater. Sci. 9, pp.496-505
- Jung KO, Kim TJ, Yu JH, Rhee S, Zhao W, Byunghang Ha, Red-Horse K, Gambhir SS & Pratx G, "Whole-body tracking of single cells via positron emission tomography", Nat. Biomed. Eng. 4, pp. 835–844
- Neufeld M, Lutzke A, Pratx G & Sun C, “High-Z metal-organic frameworks for X-ray radiation-based cancer theranostics”, Chem. Eur. J. 27(10), pp. 3229-3237
- Ozcelik S & Pratx G, “Nuclear-targeted gold nanoparticles enhances cancer cell radiosensitization,” Nanotech. 31(41), pp. 415102
- Sun W, Zhou Z, Pratx G, Chen X & Chen H, "Nanoscintillator-Mediated X-Ray Induced Photodynamic Therapy for Deep-Seated Tumors: From Concept to Biomedical Applications," Theranostics 10(3), pp. 1296-1318
- Nejadnik H, Jung KO, Theruvath AJ, Kiru L, Liu A, Wu W, Sulchek T, Pratx G & Daldrup-Link HE, "Instant labeling of therapeutic cells for multimodality imaging," Theranostics 10, 6024-6034
- Liu Z†, Jung KO†, Takahata R, Sakamoto M, Teranishi T, Fujitsuka M, Pratx G, Osakada Y, “Hard X-ray-excited optical luminescence from protein-directed Au~20 clusters,” RSC Advances 10, 13824-13829 †equal contribution
- Kim TJ, Wang Q, Shelor M & Pratx G, “Single-cell radioluminescence microscopy with two-fold higher sensitivity using dual scintillator configuration,” PLOS One 15(7), pp. e0221241
- Sung Y, Tetrault MA, Takahashi K, Ouyang J, Pratx G, El Fakhri G & Normandin MD, "Dependence of fluorodeoxyglucose (FDG) uptake on cell cycle and dry mass: a single-cell study using a multi-modal radiography platform," Sci. Rep. 10, pp. 4280
2019
- Pratx G & Kapp DS, “A computational model of radiolytic oxygen depletion during FLASH irradiation and its effect on the oxygen enhancement ratio,” Phys. Med. Biol. 64, pp. 185005 [PDF] [PubMed]
- Türkcan S, Kiru L, Naczynski D, Sasportas LS & Pratx G, "Lactic acid accumulation in the tumor microenvironment suppresses 18F- FDG uptake," Cancer Res. 79(2), pp. 410-419 [PubMed]
- Almasi S & Pratx G, "High-resolution radioluminescence microscopy image reconstruction via ionization track analysis," IEEE Trans. Radiat. Plasma Med. Sci. 3(6), pp. 660-667
- Ren Y, Winter H, Rosch J, Jung KO, Duross A, Landry M, Pratx G & Sun C, “PEGylated β-NaGdF4:Tb@CaF2 core/shell nanophosphors for enhanced radioluminescence and folate receptor targeting,” ACS Appl. Nano Mater. 2(6), pp. 3718-3727
- Badieirostami M, Carpenter C, Pratx G, Xing L & Sun C, “Upconversion Luminescence Imaging of Tumors with EGFR-Affibody Conjugated Nanophosphors,” MRS Advances 4(46-47), pp. 2461-2470
- Pratx G & Kapp DS, "Ultra-high dose rate FLASH irradiation may spare hypoxic stem cell niches in normal tissues," Int. J. Radiat. Oncol. Biol. Phys. 105(1), pp. 190-192
- Sengupta D, Mongersun A, von Eyben R, Abbyad P & Pratx G, “Multiplexed measurements of single-cell FDG uptake and lactate release using droplet microfluidics,”Technol. Cancer. Res. Treat. 18, pp. 1-9
- Klein J, Sun C & Pratx G, "Radioluminescence in biomedicine: physics, applications, and models," Phys. Med. Biol. 64(4), pp. 04TR1
- Almasi S & Pratx G, “Cloud computing for Big Data,” in “Big Data in radiation oncology,” edited by Deng J & Xing L, CRC Press
- Sengupta D & Pratx G, “Radioluminescence Microscopy: A Quantitative Method for Radioisotopic Imaging of Metabolic Fluxes in Living Cancer Cells,” in “Cancer Metabolism,” edited by Haznadar M, Methods in Molecular Biology series, Humana Press
2018
- Choi J, Jung K & Pratx G, “A gold nanoparticle system for enhancement of radiotherapy and simultaneous monitoring of reactive-oxygen-species formation,” Nanotechnology 29(50), pp. 504001
- Pratx G, Kapp DS, "In Regard to Yoon et al," Int. J. Radiat. Oncol. Biol. Phys. 101(2) pp. 494-495
- Kim TJ, Jung KO, Fahimian B, Pratx G, "Flexible optically stimulated luminescence band for 1-D in vivo radiation dosimetry," Phys. Med. Biol. 63(16), pp. 165006
- Jung KO, Jo H, Yu JH, Gambhir SS, Pratx G, "Development and MPI tracking of novel hypoxia-targeted theranostic exosomes," Biomaterials. 177, pp. 139-148
- Pratx G, Kapp DS, “Is Cherenkov luminescence bright enough for photodynamic therapy?” Nature Nanotech. 13, pp. 354
- Sengupta D. Kim TJ, Almansi S, Miller S, Marton Z, Nagarkar V, Pratx G, "Development and characterization of a scintillating imaging dish for radioluminescence microscope," Analyst, 143, pp. 1862-1869
2017
- Kiru L, Kim TK, Shen B, Chin FT & Pratx G, "Single-cell imaging using radioluminescence microscopy reveals unexpected binding target for [18F]HFB," Mol. Imaging Biol. 20(3), pp. 378-387
- Wang Q, Sengupta D, Kim TJ & Pratx G, "In silico optimization of radioluminescence microscopy," J. Biophotonics. 11, pp. e201700138
- Gallina ME, Kim TJ, Shelor M, Vasquez J, Mongersun A, Kim M, Tang SKY, Abbyad P & Pratx G, “Towards a droplet-based single-cell radiometric assay,” Anal. Chem. 89 (12), pp. 6472–6481 [PubMed]
- Wang Q, Sengupta D, Kim TJ, & Pratx G, “Performance evaluation of 18F radioluminescence microscopy using computational simulation,” Med. Phys. 77(5), pp. 1782–1795 [PubMed]
- Kim TJ, Türkcan S & Pratx G, “Modular low-light microscope for imaging cellular bioluminescence and radioluminescence,” Nat. Protoc. 12, pp. 1055–1076 [PubMed]
- Pratx G, "A tale of two photons: Radioluminescence and its application in molecular imaging," Proc. SPIE 10049
2016
- Li H & Pratx G, "Simultaneous spatiotemporal tracking of multiple positron sources using spectral clustering," Proc. IEEE NSS/MIC
- King MT, Jenkins CH, Sun C, Carpenter CM, Ma X, Cheng K, Le QT, Sunwoo JB, Cheng Z, Pratx G & Xing L, “Flexible radioluminescence imaging for FDG-guided surgery,” Med. Phys. 43(1), pp. 5298-5306 [PubMed]
- Türkcan S, Naczynski D, Nolley R, Sasportas LS, Peehl D, and Pratx G, “Endoscopic detection of cancer with lensless radioluminescence imaging and machine vision,” Sci. Rep. 6, pp. 30737 [PubMed]
- Sengupta D & Pratx G, "Single-cell characterization of FLT uptake with radioluminescence microscopy," J. Nucl. Med. 57(7), pp. 1136-1140 [PubMed]
- Ouyang Y, Kim TJ & Pratx G, "Evaluation of a BGO-based PET system for single-cell tracking performance by simulation and phantom studies," Mol. Imaging 15, pp. 1-8 [PubMed]
- Mongersun A, Smeenk I, Pratx G, Asuri P & Abbyad P, "Droplet microfluidic platform for the determination of single-cell lactate release," Anal. Chem. 88(6), pp. 3257–3263 [PubMed]
- Sengupta D & Pratx G, "Imaging metabolic heterogeneity in cancer", Mol. Cancer 15(1), pp. 1-12 [PubMed]
2015
- Kim TJ, Türkcan S, Ceballos A & Pratx G, "Modular platform for low-light microscopy," Biomed. Opt. Express 6(11), pp. 4585-4598[PubMed]
- Natarajan A, Türkcan S, Gambhir SS & Pratx G, "A multiscale framework for imaging radiolabeled therapeutics," Mol. Pharm. 2015 12 (12), pp. 4554-4560 [PubMed] (Selected for ACS Editor's Choice)
- Sengupta D, Miller S, Marton Z, Chin F, Nagarkar V & Pratx G. "Bright Lu2O3:Eu thin-film scintillators for high-resolution radioluminescence microscopy", Adv. Healthc. Mater. 4(14), pp. 2064-2070 [PubMed]
- Tüerkcan S., Nguyen J, Vilalta M, Shen B, Chin F, Pratx G & Abbyad P. "Single-cell analysis of [18F]fluorodeoxyglucose uptake by droplet radiofluidics", Anal. Chem. 87(13), pp. 6667-6673 [PubMed]
- Volotskova O, Sun C, Stafford JH, Koh AL, Ma X, Cheng Z, Cui B, Pratx G & Xing L. "Efficient radioisotope energy transfer by gold nanoclusters for molecular imaging", Small 11(32), pp. 4002-4008 [PubMed]
- King MT, Carpenter CM, Sun C, Ma X, Le QT, Sunwoo JB, Cheng Z, Pratx G & Xing L. "β-Radioluminescence imaging: A comparative evaluation with Cerenkov luminescence imaging", J. Nucl. Med. 56(9), pp. 1458-1464 [PubMed]
2014
- Naczynski DJ, Sun C, Turkcan S, Jenkins C, Koh AL, Ikeda D, Pratx G & Xing L, “X-ray-Induced Shortwave Infrared Biomedical Imaging Using Rare-Earth Nanoprobes”, Nano Lett. 15(1), pp. 96-102 [PubMed]
- Lee KS, Kim TJ, Pratx G, “Single-Cell Tracking with PET using a Novel Trajectory Reconstruction Algorithm,” IEEE Trans. Med. Imag., 34(4), pp. 994-1003 [PubMed]
- Carpenter CM, Ma X, Liu H, Sun C, Pratx G, Wang J, Gambhir SS, Xing L & Cheng Z, “Cerenkov Luminescence Endoscopy: Improved Molecular Sensitivity with β-Emitting Radiotracers,” J. Nucl. Med. 55(11), pp. 1905-1909 [Pubmed]
- Ahmad M, Pratx G, Bazalova M & Xing L, "X-ray luminescence and X-ray fluorescence computed tomography: New molecular imaging modalities," IEEE Access 2, pp.1051-1061
- Zaman RT, Kosuge H, Pratx G, Carpenter C, Xing L, McConnell MV, "Fiber-optic system for dual-modality imaging of glucose probes 18F-FDG and 6-NBDG in atherosclerotic plaques", PLoS ONE 9(9), e108108 [PubMed]
- Sasportas LS, Hori SS, Pratx G, Gambhir SS, “Detection and quantitation of circulating tumor cell dynamics by bioluminescence imaging in an orthotopic mammary carcinoma model”, PLoS ONE 9(9), e105079 [PubMed]
- Osakada Y, Pratx G, Sun C, Sakamoto M, Ahmad M, Volotskova O, Ong Q, Teranishi T, Harada Y, Xing L, & Cui B, “Hard X-ray-induced optical luminescence via biomolecule-directed metal clusters”, Chem. Commun., 50(26), pp. 3549-3551 [Pubmed]
- Fahimian B, Ceballos A, Turkcan S, Kapp DS & Pratx G, “Seeing the invisible: Direct visualization of therapeutic radiation beams using air scintillation”, Med. Phys., 41(1), pp. 010702-010708 [Pubmed] (Highlighted on MedicalPhysicsWeb)
2013
- Bazalova M, Ahmad M, Pratx G & Xing L, “L-shell x-ray fluorescence computed tomography (XFCT) imaging of cisplatin”, Phys. Med. Biol., 59(1), pp. 219 [Pubmed]
- Olcott PD, Pratx G, Johnson DL, Mitra E, Niederkohr R & Levin CS, “Clinical evaluation of a novel intraoperative handheld gamma camera for sentinel lymph node biopsy”, Phys. Med., 30(3), pp. 340-345 [Pubmed]
- Pratx G, Chen K, Sun C, Axente M, Sasportas L, Carpenter C & Xing L, "High-Resolution Radioluminescence Microscopy of FDG Uptake by Reconstructing the Beta Ionization Track", J. Nucl. Imag. 54(10) pp.1841-1846 [Pubmed] (Highlighted on MedicalPhysicsWeb)
- Cui JY, Pratx G, Meng B & Levin CS, "Distributed MLEM: an iterative tomographic image reconstruction algorithm for distributed memory architectures", IEEE Trans. Med. Imag. 32(5) pp. 957-967 [Pubmed]
- Kuang Y, Pratx G, Bazalova M, Qian J, Meng B & Xing L, "Development of XFCT Imaging Strategy for Monitoring the Spatial Distribution of Platinum-based Chemodrugs: Instrumentation and Phantom Validation", Med. Phys. 40(3), pp. 030701 [Pubmed]
- Kuang Y, Pratx G, Bazalova M, Meng B, Qian J & Xing L, "First demonstration of multiplexed X-ray fluorescence computed tomography (XFCT) imaging", IEEE Trans. Med. Imag. 32(2), pp. 262-267 [Pubmed]
- Osakada Y, Pratx G, Hanson L, Solomon PE, Cui B & Xing L, "X-ray excitable luminescent polymer dots doped with iridium(III) complex", Chem. Commun. 49, pp. 4319-4321 [Pubmed]
2012
- Xiang L, Han B, Carpenter CM, Pratx G, Kuang Y & Xing L, "X-ray acoustic computed tomography with pulsed X-ray beam from a medical linear accelerator", Med. Phys. 40(1), pp. 010701 [Pubmed]
- Pratx G, Chen K, Sun C, Martin L, Carpenter CM, Olcott PD & Xing L, "Radioluminescence microscopy: Measuring the heterogeneous uptake of radiotracers in single living cells", PLOS One7(10), e46285 [Pubmed]
- Liu HG, Carpenter CM, Jiang H, Pratx G, Sun C, Buchin MP, Gambhir SS, Xing L, & Cheng Z,"Intraoperative imaging of tumors using Cerenkov luminescence endoscopy: A feasibility experimental study", J. Nucl. Med. 53(10), pp. 1579-1584 [Pubmed]
- Bazalova M, Kuang Y, Pratx G & Xing L, "Investigation of x-ray fluorescence computed tomography (XFCT) and K-edge imaging", IEEE Trans. Med. Imag. 31(8), pp. 1620-1627 [Pubmed]
- Carpenter CM, Sun C, Pratx G, Liu H, Cheng Z & Xing L, "Radioluminescent nanophosphors enable multiplexed small-animal imaging", Opt. Express 20(11), pp. 11598-11604 [Pubmed]
2011
- Cui JY, Pratx G, Prevrhal S & Levin CS, "Fully 3-D list-mode time-of-flight PET image reconstruction on GPUs using CUDA", Med. Phys. 38(12), pp. 6775-6786 [Pubmed]
- Meng B, Pratx G & Xing L, "Ultra-fast and scalable cone-beam CT reconstruction using MapReduce in a cloud computing environment", Med. Phys. 38(12) pp. 6603-6609 [Pubmed]
- Pratx G & Xing L, "Monte Carlo simulation of photon migration in a cloud computing environment with MapReduce", J. Biomed. Opt. 16(12) pp. 125003 [Pubmed]
- Kalantzis G, Vasquez-Quino LA, Zalman T, Pratx G & Lei Y, "Toward IMRT 2D dose modeling using artificial neural networks: A feasibility study", Med. Phys. 38(10), pp. 5807-5817 [Pubmed]
- Wang H, Ma Y, Pratx G & Xing L, "Toward real-time Monte Carlo simulation using a commercial cloud computing infrastructure", Phys. Med. Bio. 56(17) pp. 175-181 [Pubmed]
- Pratx G & Levin CS, "Online detector response calculations for high-resolution PET image reconstruction", Phys. Med. Bio. 56(13) pp. 4023-4040 [Pubmed]
- Sun C, Pratx G, Carpenter CM, Liu HG, Cheng Z, Gambhir SS & Xing L, "Synthesis and radioluminescence of PEGylated Eu3+-dopednanophosphors as bioimaging probes", Adv. Mater., 23(24), pp. H195-H199 [Pubmed]
- Carpenter CM, Pratx G, Sun C & Xing L, "Limited-angle x-ray luminescence tomography: Methodology and feasibility study", Phys. Med. Bio. 56(12), pp. 3487-3502 [Pubmed]
- Pratx G & Xing L, "GPU computing in medical physics: A review", Med. Phys. 38(5), pp. 2685-2698 [Pubmed]
2010
- Pratx G, Carpenter CM, Sun C & Xing L, "X-Ray luminescence computed tomography via selective excitation: A feasibility study", IEEE Trans. Med. Imag. 29(12), pp. 1992-1999 [Pubmed]
- Pratx G, Surti S & Levin CS, "Fast list-mode reconstruction for time-of-flight PET using graphics hardware", IEEE Trans. Nucl. Sci. 58(1), pp. 105-109
- Pratx G, Carpenter CM, Sun C & Xing L, "Tomographic molecular imaging of X-ray-excitable nanoparticles", Opt. Lett. 35(20), pp. 3345-3347 [Pubmed]
- Reynolds PD, Olcott PD, Pratx G, Lau FWY & Levin CS, "Convex optimization of coincidence time resolution for a high-resolution PET system", IEEE Trans. Med. Imag. 30(2), pp. 391-400 [Pubmed]
- Sun C, Carpenter CM, Pratx G & Xing L, "Facile synthesis of amine functionalized Eu3+-doped La(OH)3 nanophosphors for bioimaging", Nanoscale Res. Lett. 6(1), pp. 24-30 [Pubmed]
- Gu Y, Pratx G, Lau FWY & Levin CS, "Effects of multiple-interaction photon events in a high resolution PET system that uses 3-D positioning detectors", Med. Phys. 37(10), pp. 5494-5509 [Pubmed]
- Carpenter CM, Sun C, Pratx G, Rao R & Xing L, "Hybrid X-ray/optical luminescence imaging: Characterization of experimental conditions", Med. Phys. 37(8), pp. 4011-4019 [Pubmed]
2009