Poston Lab Publications

Vision-based Estimation of MDS-UPDRS Gait Scores for Assessing Parkinson's Disease Motor Severity.
Lu M, Poston K, Pfefferbaum A, Sullivan EV, Fei-Fei L, Pohl KM, Niebles JC, Adeli E. Med Image Comput Comput Assist Interv. 2020 Oct;12263:637-647. doi: 10.1007/978-3-030-59716-0_61. Epub 2020 Sep 29.

Cognitive and motor deficits in older adults with HIV infection: Comparison with normal ageing and Parkinson's disease.
Müller-Oehring EM, Fama R, Levine TF, Hardcastle C, Goodcase R, Martin T, Prabhakar V, Brontë-Stewart HM, Poston KL, Sullivan EV, Schulte T. J Neuropsychol. 2020 Oct 8. doi: 10.1111/jnp.12227. Online ahead of print.

Quantitative Digitography Measures Fine Motor Disturbances in Chronically Treated HIV Similar to Parkinson's Disease
Prabhakar V, Martin T, Müller-Oehring EM, Goodcase R, Schulte T, Poston KL, Brontë-Stewart HM. Front Aging Neurosci. 2020 Oct 7;12:539598. doi: 10.3389/fnagi.2020.539598. eCollection 2020. PMID: 33132893  

Sensorimotor Inhibition and Mobility in Genetic Subgroups of Parkinson's Disease
Martini DN, Morris R, Kelly VE, Hiller A, Chung KA, Hu SC, Zabetian CP, Oakley J, Poston K, Mata IF, Edwards KL, Lapidus JA, Grabowski TJ, Montine TJ, Quinn JF, Horak F. Front Neurol. 2020 Sep 4;11:893. doi: 10.3389/fneur.2020.00893. eCollection 2020.

Longitudinal Measurements of Glucocerebrosidase activity in Parkinson's patients
Alcalay RN, Wolf P, Chiang MSR, Helesicova K, Zhang XK, Merchant K, Hutten SJ, Scherzer C, Caspell-Garcia C, Blauwendraat C, Foroud T, Nudelman K, Gan-Or Z, Simuni T, Chahine LM, Levy O, Zheng D, Li G, Sardi SP; Parkinson’s Progression Markers Initiative. Ann Clin Transl Neurol. 2020 Sep 5. doi: 10.1002/acn3.51164. Online ahead of print.

Multivariate prediction of dementia in Parkinson's disease
Phongpreecha T, Cholerton B, Mata IF, Zabetian CP, Poston KL, Aghaeepour N, Tian L, Quinn JF, Chung KA, Hiller AL, Hu SC, Edwards KL, Montine TJ. NPJ Parkinsons Dis. 2020 Aug 25;6:20. doi: 10.1038/s41531-020-00121-2. eCollection 2020. PMID: 32885039 Free PMC article.

Ultra-Low-Dose 18 F-Florbetaben Amyloid PET Imaging Using Deep Learning with Multi-Contrast MRI Inputs
Chen KT, Gong E, de Carvalho Macruz FB, Xu J, Boumis A, Khalighi M, Poston KL, Sha SJ, Greicius MD, Mormino E, Pauly JM, Srinivas S, Zaharchuk G. Radiology. 2020 Sep;296(3):E195. doi: 10.1148/radiol.2020202527.

White Matter Hyperintensities Related to Parkinson's Disease Executive Function
Linortner P, McDaniel C, Shahid M, Levine TF, Tian L, Cholerton B, Poston KL. Mov Disord Clin Pract. 2020 Apr 30;7(6):629-638. doi: 10.1002/mdc3.12956. eCollection 2020 Aug.

Hallucinations and Development of Dementia in Parkinson's Disease
Gryc W, Roberts KA, Zabetian CP, Weintraub D, Trojanowski JQ, Quinn JF, Hiller AL, Chung KA, Poston KL, Yang L, Hu SC, Edwards KL, Montine TJ, Cholerton BA. J Parkinsons Dis. 2020 Jul 27. doi: 10.3233/JPD-202116. Online ahead of print.

Tau PET imaging with 18 F-PI-2620 in aging and neurodegenerative diseases
Mormino EC, Toueg TN, Azevedo C, Castillo JB, Guo W, Nadiadwala A, Corso NK, Hall JN, Fan A, Trelle AN, Harrison MB, Hunt MP, Sha SJ, Deutsch G, James M, Fredericks CA, Koran ME, Zeineh M, Poston K, Greicius MD, Khalighi M, Davidzon GA, Shen B, Zaharchuk G, Wagner AD, Chin FT. Eur J Nucl Med Mol Imaging. 2020 Jun 23. doi: 10.1007/s00259-020-04923-7. Online ahead of print.

Alterations of Brain Signal Oscillations in Older Individuals with HIV Infection and Parkinson's Disease
Müller-Oehring EM, Hong JY, Hughes RL, Kwon D, Brontë-Stewart HM, Poston KL, Schulte T. J Neuroimmune Pharmacol. 2020 Apr 14. doi: 10.1007/s11481-020-09914-x. Online ahead of print.

Substantia Nigra Volume Dissociates Bradykinesia and Rigidity from Tremor in Parkinson's Disease: A 7 Tesla Imaging Study
Poston KL, Ua Cruadhlaoich MAI, Santoso LF, Bernstein JD, Liu T, Wang Y, Rutt B, Kerchner GA, Zeineh MM. J Parkinsons Dis. 2020;10(2):591-604. doi: 10.3233/JPD-191890.

Clinical and Dopamine Transporter Imaging Characteristics of Leucine- Rich Repeat Kinase 2 (LRRK2) and Glucosylceramidase Beta (GBA) Parkinson's Disease Participants in the Parkinson's Progression Markers Initiative: A Cross-Sectional Study
Simuni T, Brumm MC, Uribe L, Caspell-Garcia C, Coffey CS, Siderowf A, Alcalay RN, Trojanowski JQ, Shaw LM, Seibyl J, Singleton A, Toga AW, Galasko D, Foroud T, Nudelman K, Tosun-Turgut D, Poston K, Weintraub D, Mollenhauer B, Tanner CM, Kieburtz K, Chahine LM, Reimer A, Hutten S, Bressman S, Marek K; Parkinson's Progression Markers Initiative Investigators. Mov Disord. 2020 May;35(5):833-844. doi: 10.1002/mds.27989. Epub 2020 Feb 19.

Soluble TREM2 is elevated in Parkinson's disease subgroups with increased CSF tau
Wilson EN, Swarovski MS, Linortner P, Shahid M, Zuckerman AJ, Wang Q, Channappa D, Minhas PS, Mhatre SD, Plowey ED, Quinn JF, Zabetian CP, Tian L, Longo FM, Cholerton B, Montine TJ, Poston KL, Andreasson KI. Brain. 2020 Mar 1;143(3):932-943. doi: 10.1093/brain/awaa021.

Participant and Study Partner Reported Impact of Cognition on Functional Activities in Parkinson's Disease.
Cholerton B, Poston KL, Tian L, Quinn JF, Chung KA, Hiller AL, Hu SC, Specketer K, Montine TJ, Edwards KL, Zabetian CP. Mov Disord Clin Pract. 2019 Dec 14;7(1):61-69. doi: 10.1002/mdc3.12870. eCollection 2020 Jan

Cognitive associations with comprehensive gait and static balance measures in Parkinson's disease
Morris R, Martini DN, Smulders K, Kelly VE, Zabetian CP, Poston K, Hiller A, Chung KA, Yang L, Hu SC, Edwards KL, Cholerton B, Grabowski TJ, Montine TJ, Quinn JF, Horak F. Parkinsonism Relat Disord. 2019 Dec;69:104-110. doi: 10.1016/j.parkreldis.2019.06.014. Epub 2019 Jul 4.

Clinical and dopamine transporter imaging characteristics of non-manifest LRRK2 and GBA mutation carriers in the Parkinson's Progression Markers Initiative (PPMI): a cross-sectional study
Simuni T, Uribe L, Cho HR, Caspell-Garcia C, Coffey CS, Siderowf A, Trojanowski JQ, Shaw LM, Seibyl J, Singleton A, Toga AW, Galasko D, Foroud T, Tosun D, Poston K, Weintraub D, Mollenhauer B, Tanner CM, Kieburtz K, Chahine LM, Reimer A, Hutten SJ, Bressman S, Marek K; PPMI Investigators. Lancet Neurol. 2020 Jan;19(1):71-80. doi: 10.1016/S1474-4422(19)30319-9. Epub 2019 Oct 31.

MRI biomarkers of motor and non-motor symptoms in Parkinson's disease
Ryman SG, Poston KL. Parkinsonism Relat Disord. 2020 Apr;73:85-93. doi: 10.1016/j.parkreldis.2019.10.002. Epub 2019 Oct 10.

Establishing a framework for neuropathological correlates and glymphatic system functioning in Parkinson's disease.
Sundaram S, Hughes RL, Peterson E, Müller-Oehring EM, Brontë-Stewart HM, Poston KL, Faerman A, Bhowmick C, Schulte T. Neurosci Biobehav Rev. 2019 Aug;103:305-315. doi: 10.1016/j.neubiorev.2019.05.016. Epub 2019 May 24.

Hippocampal CA1 subfield predicts episodic memory impairment in Parkinson's disease.
La C, Linortner P, Bernstein JD, Ua Cruadhlaoich MAI, Fenesy M, Deutsch GK, Rutt BK, Tian L, Wagner AD, Zeineh M, Kerchner GA, Poston KL. Neuroimage Clin. 2019;23:101824. doi: 10.1016/j.nicl.2019.101824. Epub 2019 Apr 18.

Cognitive Performance in Parkinson's Disease in the Brain Health Registry.
Cholerton B, Weiner MW, Nosheny RL, Poston KL, Mackin RS, Tian L, Ashford JW, Montine TJ. J Alzheimers Dis. 2019;68(3):1029-1038. doi: 10.3233/JAD-181009.

Lewy Body Dementia Association's Research Centers of Excellence Program: Inaugural Meeting Proceedings.
Peterson B, Armstrong M, Galasko D, Galvin JE, Goldman J, Irwin D, Paulson H, Kaufer D, Leverenz J, Lunde A, McKeith IG, Siderowf A, Taylor A, Amodeo K, Barrett M, Domoto-Reilly K, Duda J, Gomperts S, Graff-Radford N, Holden S, Honig L, Huddleston D, Lippa C, Litvan I, Manning C, Marder K, Moussa C, Onyike C, Pagan F, Pantelyat A, Pelak V, Poston K, Quinn J, Richard I, Rosenthal LS, Sabbagh M, Scharre D, Sha S, Shill H, Torres-Yaghi Y, Christie T, Graham T, Richards I, Koehler M, Boeve B. Alzheimers Res Ther. 2019 Mar 13;11(1):23. doi: 10.1186/s13195-019-0476-1.

An increased rate of longitudinal cognitive decline is observed in Parkinson's disease patients with low CSF Aß42 and an APOE ε4 allele.
Shahid M, Kim J, Leaver K, Hendershott T, Zhu D, Cholerton B, Henderson VW, Tian L, Poston KL. Neurobiol Dis. 2019 Jul;127:278-286. doi: 10.1016/j.nbd.2019.02.023. Epub 2019 Feb 28.

Comparative sensitivity of the MoCA and Mattis Dementia Rating Scale-2 in Parkinson's disease.
Hendershott TR, Zhu D, Llanes S, Zabetian CP, Quinn J, Edwards KL, Leverenz JB, Montine T, Cholerton B, Poston KL. Mov Disord. 2019 Feb;34(2):285-291. doi: 10.1002/mds.27575. Epub 2018 Dec 10.

Feasibility and safety of lumbar puncture in the Parkinson's disease research participants: Parkinson's Progression Marker Initiative (PPMI).
Prakash N, Caspell-Garcia C, Coffey C, Siderowf A, Tanner CM, Kieburtz K, Mollenhauer B, Galasko D, Merchant K, Foroud T, Chahine LM, Weintraub D, Casaceli C, Dorsey R, Wilson R, Herzog M, Daegele N, Arnedo V, Frasier M, Sherer T, Marek K, Simuni T; Parkinson's Progression Markers InitiativeSteering Committee; Study Cores; Site Investigators; Coordinators; Industry and Scientific Advisory Board. Parkinsonism Relat Disord. 2019 May;62:201-209. doi: 10.1016/j.parkreldis.2018.12.025. Epub 2019 Jan 31.

Episodic recognition memory and the hippocampus in Parkinson's disease: A review.
Das T, Hwang JJ, Poston KL. Cortex. 2019 Apr;113:191-209. doi: 10.1016/j.cortex.2018.11.021. Epub 2018 Dec 4.

The Parkinson's progression markers initiative (PPMI) - establishing a PD biomarker cohort.
Marek K, Chowdhury S, Siderowf A, Lasch S, Coffey CS, Caspell-Garcia C, Simuni T, Jennings D, Tanner CM, Trojanowski JQ, Shaw LM, Seibyl J, Schuff N, Singleton A, Kieburtz K, Toga AW, Mollenhauer B, Galasko D, Chahine LM, Weintraub D, Foroud T, Tosun-Turgut D, Poston K, Arnedo V, Frasier M, Sherer T; Parkinson's Progression Markers Initiative. Ann Clin Transl Neurol. 2018 Oct 31;5(12):1460-1477. doi: 10.1002/acn3.644. eCollection 2018 Dec.

Ultra-Low-Dose 18F-Florbetaben Amyloid PET Imaging Using Deep Learning with Multi-Contrast MRI Inputs.
Chen KT, Gong E, de Carvalho Macruz FB, Xu J, Boumis A, Khalighi M, Poston KL, Sha SJ, Greicius MD, Mormino E, Pauly JM, Srinivas S, Zaharchuk G. Radiology. 2019 Mar;290(3):649-656. doi: 10.1148/radiol.2018180940. Epub 2018 Dec 11.

Information processing deficit in older adults with HIV infection: A comparison with Parkinson's disease.
Sundaram S, Müller-Oehring EM, Fama R, Brontë-Stewart HM, Poston KL, Goodcase R, Martin T, Prabhakar V, Karpf J, Schulte T. Neuropsychology. 2019 Feb;33(2):157-168. doi: 10.1037/neu0000500. Epub 2018 Nov 26.

Dopamine-related dissociation of cortical and subcortical brain activations in cognitively unimpaired Parkinson’s disease patients OFF and ON medications.
Kim J, Zhang K, Cai W, YorkWilliams S, Ua Cruadhlaoich MAI, Llanes S, Menon V, Poston KL. Neuropsychologia. 2018 Jul 21;119:24-33. doi: 10.1016/j.neuropsychologia.2018.07.024.

Sex differences in progression to mild cognitive impairment and dementia in Parkinson's disease.
Cholerton B, Johnson CO, Fish B, Quinn JF, Chung KA, Peterson-Hiller AL, Rosenthal LS, Dawson TM, Albert MS, Hu SC, Mata IF, Leverenz JB, Poston KL, Montine TJ, Zabetian CP, Edwards KL. Parkinsonism Relat Disord. 2018 May; 50:29-36. doi: 10.1016/j.parkreldis.2018.02.007. Epub 2018 Feb 9.

Longitudinal change of clinical and biological measures in early Parkinson's disease: Parkinson's progression markers initiative cohort.
Simuni T, Siderowf A, Lasch S, Coffey CS, Caspell-Garcia C, Jennings D, Tanner CM, Trojanowski JQ, Shaw LM, Seibyl J, Schuff N, Singleton A, Kieburtz K, Toga AW, Mollenhauer B, Galasko D, Chahine LM, Weintraub D, Foroud T, Tosun D, Poston K, Arnedo V, Frasier M, Sherer T, Chowdhury S, Marek K; Parkinson's Progression Marker Initiative*. Mov Disord. 2018 Mar 23. doi: 10.1002/mds.27361.

Slower saccadic reading in Parkinson’s disease.
Jehangir N, Yu CY, Song J, Shariati MA, Binder S, Beyer J, Santini V, Poston KL, Liao YJ. PLoS One. 2018 Jan 24;13(1):e0191005. doi: 10.1371/journal.pone.0191005. eCollection 2018.

7T MRI subthalamic nucleus atlas for use with 3T MRI.
Milchenko M, Norris SA, Poston KL, Campbell MC, Ushe M, Perlmutter JS, Snyder AZ. J Med Imaging (Bellingham). 2018 Jan;5(1):015002. doi: 10.1117/1.JMI.5.1.015002. Epub 2018 Jan 8.

Further study of the Montreal Cognitive Assessment’s domain-specific metrics could allow for international data comparison and collaboration.
Hendershott TR, Poston KL. Parkinsonism Relat Disord. 2018 Mar;48:101. doi: 10.1016/j.parkreldis.2017.11.336. Epub 2017 Nov 21.

Distinct alternations in Parkinson’s medication-state and disease-state connectivity.
Ng B, Varoquaux G, Poline JB, Thirion B, Greicius MD, Poston KL. Neuroimage Clin. 2017 Sep 6;16:575-585. doi: 10.1016/j.nicl.2017.09.004. eCollection 2017.

Long-term follow-up of a randomized AAV2-GAD gene therapy trial for Parkinson's disease.
Niethammer M, Tang CC, LeWitt PA, Rezai AR, Leehey MA, Ojemann SG, Flaherty AW, Eskandar EN, Kostyk SK, Sarkar A, Siddiqui MS, Tatter SB, Schwalb JM, Poston KL, Henderson JM, Kurlan RM, Richard IH, Sapan CV, Eidelberg D, During MJ, Kaplitt MG, Feigin A. JCI Insight. 2017 Apr 6;2(7):e90133. doi: 10.1172/jci.insight.90133.

Domain-specific accuracy of the Montreal Cognitive Assessment subsections in Parkinson's disease.
Hendershott TR, Zhu D, Llanes S, Poston KL. Parkinsonism Relat Disord. 2017 May;38:31-34. doi: 10.1016/j.parkreldis.2017.02.008. Epub 2017 Feb 7.

Abnormal eye movement behavior during reading in Parkinson's disease.
Yu CY, Lee T, Shariati MA, Santini V, Poston KL, Liao YJ. Parkinsonism Relat Disord. 2016 Nov;32:130-132. doi: 10.1016/j.parkreldis.2016.08.008. Epub 2016 Aug 12.

The effects of dopamine on digit span in Parkinson's disease.
Warden C, Hwang J, Marshall A, Fenesy M, Poston KL. J Clin Mov Disord. 2016 Mar 7;3:5. doi: 10.1186/s40734-016-0033-z. eCollection 2016.

Compensatory neural mechanisms in cognitively unimpaired Parkinson disease.
Poston KL, YorkWilliams S, Zhang K, Cai W, Everling D, Tayim FM, Llanes S, Menon V. Ann Neurol. 2016 Mar;79(3):448-63. doi: 10.1002/ana.24585. Epub 2016 Feb 10.

Do CSF Biomarkers Predict Progression to Cognitive Impairment in Parkinson's disease patients? A Systematic Review. Leaver K, Poston KL. Neuropsychol Rev. 2015 Dec;25(4):411-23. doi: 10.1007/s11065-015-9307-8. Epub 2015 Dec 1.

Gene delivery of neurturin to putamen and substantia nigra in Parkinson disease: A double-blind, randomized, controlled trial
Warren Olanow C, Bartus RT, Baumann TL, Factor S, Boulis N, Stacy M, Turner DA, Marks W, Larson P, Starr PA, Jankovic J, Simpson R, Watts R, Guthrie B, Poston K, Henderson JM, Stern M, Baltuch G, Goetz CG, Herzog C, Kordower JH, Alterman R, Lozano AM, Lang AE. Ann Neurol. 2015 Jun 10. doi: 10.1002/ana.24436.

Task-rest modulation of basal ganglia connectivity in mild to moderate Parkinson’s disease
Müller-Oehring EM, Sullivan EV, Pfefferbaum A, Huang NC, Poston KL, Bronte-Stewart HM, Schulte T. Brain Imaging Behav. 2014 Oct 4. [Epub ahead of print]

A disease-specific metabolic brain network associated with corticobasal degeneration
Niethammer M, Tang CC, Feigin A, Allen PJ, Heinen L, Hellwig S, Amtage F, Hanspal E, Vonsattel JP, Poston KL, Meyer PT, Leenders KL, Eidelberg D. Brain. 2014 Nov;137(Pt 11):3036-46. doi: 10.1093/brain/awu256. Epub 2014 Sep 9.

Network correlates of disease severity in multiple system atrophy.
Poston KL, Tang CC, Eckert T, Dhawan V, Frucht S, Vonsattel JP, Fahn S, Eidelberg D. Neurology. 2012; 78 (16): 1237-44

AAV2-GAD gene therapy for advanced Parkinson's disease: a double-blind, sham-surgery controlled, randomised trial. LeWitt PA, Rezai AR, Leehey MA, Ojemann SG, Flaherty AW, Eskandar EN, Kostyk SK, Thomas K, Sarkar A, Siddiqui MS, Tatter SB, Schwalb JM, Poston KL, Henderson JM, Kurlan RM, Richard IH, Van Meter L, Sapan CV, During MJ, Kaplitt MG, Feigin A. Lancet Neurol. 2011; 10 (4): 309-19

Functional brain networks and abnormal connectivity in the movement disorders.
Poston KL, Eidelberg D. Neuroimage. 2011

Abnormalities in metabolic network activity precede the onset of motor symptoms in Parkinson's disease.
Tang CC, Poston KL, Dhawan V, Eidelberg D. J Neurosci. 2010; 30 (3): 1049-56

Differential diagnosis of parkinsonism: a metabolic imaging study using pattern analysis.
Tang CC, Poston KL, Eckert T, Feigin A, Frucht S, Gudesblatt M, Dhawan V, Lesser M, Vonsattel JP, Fahn S, Eidelberg D. Lancet Neurol. 2010; 9 (2): 149-58

FDG PET in the Evaluation of Parkinson's Disease.
Poston KL, Eidelberg D. PET Clin. 2010; 5 (1): 55-64

Fragile X-associated tremor/ataxia syndrome (FXTAS) with myoclonus.
Poston KL, McGovern RA, Goldman JS, Caccappolo E, Mazzoni P. Mov Disord. 2010; 25 (4): 514-6

Action tremor of the legs in essential tremor: prevalence, clinical correlates, and comparison with age-matched controls.
Poston KL, Rios E, Louis ED. Parkinsonism Relat Disord. 2009; 15 (8): 602-5

Network biomarkers for the diagnosis and treatment of movement disorders.Poston KL, Eidelberg D. Neurobiol Dis. 2009; 35 (2): 141-7

Movement disorder emergencies.
Poston KL, Frucht SJ. J Neurol. 2008: 255 Suppl 4 2-13

Zydis selegiline in the management of Parkinson's disease.
Poston KL, Waters C. Expert Opin Pharmacother. 2007; 8 (15): 2615-24