Poston Lab Publications

2023

Prediction of neuropathologic lesions from clinical data.
Phongpreecha T, Cholerton B, Bhukari S, Chang AL, De Francesco D, Thuraiappah M, Godrich D, Perna A, Becker MG, Ravindra NG, Espinosa C, Kim Y, Berson E, Mataraso S, Sha SJ, Fox EJ, Montine KS, Baker LD, Craft S, White L, Poston KL, Beecham G, Aghaeepour N, Montine TJ. Alzheimers Dement. 2023 Jan 21. doi: 10.1002/alz.12921. Online ahead of print. PMID: 36681388

APOE effects on regional tau in preclinical Alzheimer's disease.
Young CB, Johns E, Kennedy G, Belloy ME, Insel PS, Greicius MD, Sperling RA, Johnson KA, Poston KL, Mormino EC; Alzheimer’s Disease Neuroimaging Initiative; A4 Study Team. Mol Neurodegener. 2023 Jan 4;18(1):1. doi: 10.1186/s13024-022-00590-4. PMID: 36597122 Free PMC article.

2022

Illusory responses across the Lewy body disease spectrum.
Shahid M, Rawls A, Ramirez V, Ryman S, Santini VE, Yang L, Sha SJ, Hall JN, Montine TJ, Lin A, Tian L, Henderson VW, Cholerton B, Yutsis M, Poston KL. Ann Neurol. 2022 Dec 13. doi: 10.1002/ana.26574. Online ahead of print. PMID: 36511519

Performance of a fully-automated Lumipulse plasma phospho-tau181 assay for Alzheimer's disease.
Wilson EN, Young CB, Ramos Benitez J, Swarovski MS, Feinstein I, Vandijck M, Le Guen Y, Kasireddy NM, Shahid M, Corso NK, Wang Q, Kennedy G, Trelle AN, Lind B, Channappa D, Belnap M, Ramirez V, Skylar-Scott I, Younes K, Yutsis MV, Le Bastard N, Quinn JF, van Dyck CH, Nairn A, Fredericks CA, Tian L, Kerchner GA, Montine TJ, Sha SJ, Davidzon G, Henderson VW, Longo FM, Greicius MD, Wagner AD, Wyss-Coray T, Poston KL, Mormino EC, Andreasson KI. Alzheimers Res Ther. 2022 Nov 12;14(1):172. doi: 10.1186/s13195-022-01116-2. PMID: 36371232  

GaitForeMer: Self-Supervised Pre-Training of Transformers via Human Motion Forecasting for Few-Shot Gait Impairment Severity Estimation.
Endo M, Poston KL, Sullivan EV, Fei-Fei L, Pohl KM, Adeli E. Med Image Comput Comput Assist Interv. 2022 Sep;13438:130-139. doi: 10.1007/978-3-031-16452-1_13. Epub 2022 Sep 16. PMID: 36342887

Parkinson's Progression Markers Initiative brain autopsy program.
Bukhari SA, Nudelman KNH, Rumbaugh M, Richeson P, Fox EJ, Montine KS, Aldecoa I, Garrido A, Franz J, Stadelmann C, Vonsattel JPG, Poston KL, Foroud TM, Montine TJ; Parkinson's Progression Markers Initiative. Parkinsonism Relat Disord. 2022 Jul 1;101:62-65. doi: 10.1016/j.parkreldis.2022.06.017. Online ahead of print. PMID: 35803091

Multimodal deep learning for Alzheimer's disease dementia assessment.
Qiu S, Miller MI, Joshi PS, Lee JC, Xue C, Ni Y, Wang Y, De Anda-Duran I, Hwang PH, Cramer JA, Dwyer BC, Hao H, Kaku MC, Kedar S, Lee PH, Mian AZ, Murman DL, O'Shea S, Paul AB, Saint-Hilaire MH, Alton Sartor E, Saxena AR, Shih LC, Small JE, Smith MJ, Swaminathan A, Takahashi CE, Taraschenko O, You H, Yuan J, Zhou Y, Zhu S, Alosco ML, Mez J, Stein TD, Poston KL, Au R, Kolachalama VB. Nat Commun. 2022 Jun 20;13(1):3404. doi: 10.1038/s41467-022-31037-5.
PMID: 35725739

Cognition as a mediator for gait and balance impairments in GBA-related Parkinson's disease.
Morris R, Martini DN, Ramsey K, Kelly VE, Smulders K, Hiller A, Chung KA, Hu SC, Zabetian CP, Poston KL, Mata IF, Edwards KL, Lapidus J, Cholerton B, Montine TJ, Quinn JF, Horak F. NPJ Parkinsons Dis. 2022 Jun 20;8(1):78. doi: 10.1038/s41531-022-00344-5.
PMID: 35725575

Divergent Cortical Tau Positron Emission Tomography Patterns Among Patients With Preclinical Alzheimer Disease.
Young CB, Winer JR, Younes K, Cody KA, Betthauser TJ, Johnson SC, Schultz A, Sperling RA, Greicius MD, Cobos I, Poston KL, Mormino EC; Alzheimer’s Disease Neuroimaging Initiative and the Harvard Aging Brain Study. JAMA Neurol. 2022 Apr 18. doi: 10.1001/jamaneurol.2022.0676. Online ahead of print. PMID: 35435938

Dopaminergic medication normalizes aberrant cognitive control circuit signalling in Parkinson's disease.
Cai W, Young CB, Yuan R, Lee B, Ryman S, Kim J, Yang L, Henderson VW, Poston KL, Menon V. Brain. 2022 Mar 31:awac007. doi: 10.1093/brain/awac007. Online ahead of print. PMID: 35357463

Neurofunctional characteristics of executive control in older people with HIV infection: a comparison with Parkinson's disease.
Müller-Oehring EM, Hong JY, Poston KL, Brontë-Stewart HM, Sullivan EV, McGlynn L, Schulte T. Brain Imaging Behav. 2022 Aug;16(4):1776-1793. doi: 10.1007/s11682-022-00645-6. Epub 2022 Mar 16. PMID: 35294979

Neuroimaging approaches to cognition in Parkinson's disease.
Montaser-Kouhsari L, Young CB, Poston KL. Prog Brain Res. 2022;269(1):257-286. doi: 10.1016/bs.pbr.2022.01.008. Epub 2022 Feb 9. PMID: 35248197

Fluid and Tissue Biomarkers of Lewy Body Dementia: Report of an LBDA Symposium.
Scott GD, Arnold MR, Beach TG, Gibbons CH, Kanthasamy AG, Lebovitz RM, Lemstra AW, Shaw LM, Teunissen CE, Zetterberg H, Taylor AS, Graham TC, Boeve BF, Gomperts SN, Graff-Radford NR, Moussa C, Poston KL, Rosenthal LS, Sabbagh MN, Walsh RR, Weber MT, Armstrong MJ, Bang JA, Bozoki AC, Domoto-Reilly K, Duda JE, Fleisher JE, Galasko DR, Galvin JE, Goldman JG, Holden SK, Honig LS, Huddleston DE, Leverenz JB, Litvan I, Manning CA, Marder KS, Pantelyat AY, Pelak VS, Scharre DW, Sha SJ, Shill HA, Mari Z, Quinn JF, Irwin DJ. Front Neurol. 2022 Jan 31;12:805135. doi: 10.3389/fneur.2021.805135. eCollection 2021. PMID: 35173668 Free PMC article. Review.

2021

Single-synapse analyses of Alzheimer's disease implicate pathologic tau, DJ1, CD47, and ApoE.
Phongpreecha T, Gajera CR, Liu CC, Vijayaragavan K, Chang AL, Becker M, Fallahzadeh R, Fernandez R, Postupna N, Sherfield E, Tebaykin D, Latimer C, Shively CA, Register TC, Craft S, Montine KS, Fox EJ, Poston KL, Keene CD, Angelo M, Bendall SC, Aghaeepour N, Montine TJ. Sci Adv. 2021 Dec 17;7(51):eabk0473. doi: 10.1126/sciadv.abk0473. Epub 2021 Dec 15. PMID: 34910503

Cognitive and motor deficits in older adults with HIV infection: Comparison with normal ageing and Parkinson's disease.
Müller-Oehring EM, Fama R, Levine TF, Hardcastle C, Goodcase R, Martin T, Prabhakar V, Brontë-Stewart HM, Poston KL, Sullivan EV, Schulte T. J Neuropsychol. 2021 Jun;15(2):253-273. doi: 10.1111/jnp.12227. Epub 2020 Oct 8. PMID: 33029951 Free PMC article.

Low soluble amyloid-β 42 is associated with smaller brain volume in Parkinson's disease.
Espay AJ, Lafontant DE, Poston KL, Caspell-Garcia C, Marsili L, Cho HR, McDaniel C, Kim N, Coffey CS, Mahajan A, Ezzat K, Sturchio A; Parkinson's Progression Markers Initiative. Parkinsonism Relat Disord. 2021 Nov;92:15-21. doi: 10.1016/j.parkreldis.2021.10.010. Epub 2021 Oct 13. PMID: 34656902

Neuropathological correlation supports automated image-based differential diagnosis in parkinsonism.
Schindlbeck KA, Gupta DK, Tang CC, O'Shea SA, Poston KL, Choi YY, Dhawan V, Vonsattel JP, Fahn S, Eidelberg D. Eur J Nucl Med Mol Imaging. 2021 Oct;48(11):3522-3529. doi: 10.1007/s00259-021-05302-6. Epub 2021 Apr 10. PMID: 33839891

CD4+ T cells contribute to neurodegeneration in Lewy body dementia.
Gate D, Tapp E, Leventhal O, Shahid M, Nonninger TJ, Yang AC, Strempfl K, Unger MS, Fehlmann T, Oh H, Channappa D, Henderson VW, Keller A, Aigner L, Galasko DR, Davis MM, Poston KL, Wyss-Coray T. Science. 2021 Nov 12;374(6569):868-874. doi: 10.1126/science.abf7266. Epub 2021 Oct 14. PMID: 34648304

Latent brain state dynamics and cognitive flexibility in older adults.
Lee B, Cai W, Young CB, Yuan R, Ryman S, Kim J, Santini V, Henderson VW, Poston KL, Menon V. Prog Neurobiol. 2022 Jan;208:102180. doi: 10.1016/j.pneurobio.2021.102180. Epub 2021 Oct 7. PMID: 34627994

Quantifying Parkinson's disease motor severity under uncertainty using MDS-UPDRS videos.
Lu M, Zhao Q, Poston KL, Sullivan EV, Pfefferbaum A, Shahid M, Katz M, Kouhsari LM, Schulman K, Milstein A, Niebles JC, Henderson VW, Fei-Fei L, Pohl KM, Adeli E. Med Image Anal. 2021 Oct;73:102179. doi: 10.1016/j.media.2021.102179. Epub 2021 Jul 21. PMID: 34340101

High cerebrospinal amyloid-β 42 is associated with normal cognition in individuals with brain amyloidosis.
Sturchio A, Dwivedi AK, Young CB, Malm T, Marsili L, Sharma JS, Mahajan A, Hill EJ, Andaloussi SE, Poston KL, Manfredsson FP, Schneider LS, Ezzat K, Espay AJ. EClinicalMedicine. 2021 Jun 28;38:100988. doi: 10.1016/j.eclinm.2021.100988. eCollection 2021 Aug. PMID: 34505023  

Cognition at Each Stage of Lewy Body Disease with Co-occurring Alzheimer's Disease Pathology.
Ryman SG, Yutsis M, Tian L, Henderson VW, Montine TJ, Salmon DP, Galasko D, Poston KL. J Alzheimers Dis. 2021;80(3):1243-1256. doi: 10.3233/JAD-201187. PMID: 33646154

Influence of common reference regions on regional tau patterns in cross-sectional and longitudinal [18F]-AV-1451 PET data.
Young CB, Landau SM, Harrison TM, Poston KL, Mormino EC; ADNI. Neuroimage. 2021 Nov;243:118553. doi: 10.1016/j.neuroimage.2021.118553. Epub 2021 Sep 3. PMID: 34487825

Association of Short and Long Sleep Duration With Amyloid-β Burden and Cognition in Aging.
Winer JR, Deters KD, Kennedy G, Jin M, Goldstein-Piekarski A, Poston KL, Mormino EC. JAMA Neurol. 2021 Aug 30. doi: 10.1001/jamaneurol.2021.2876. Online ahead of print. PMID: 34459862

Longitudinal Analysis of Multiple Neurotransmitter Metabolites in Cerebrospinal Fluid in Early Parkinson's Disease.
Kremer T, Taylor KI, Siebourg-Polster J, Gerken T, Staempfli A, Czech C, Dukart J, Galasko D, Foroud T, Chahine LM, Coffey CS, Simuni T, Weintraub D, Seibyl J, Poston KL, Toga AW, Tanner CM, Marek K, Hutten SJ, Dziadek S, Trenkwalder C, Pagano G, Mollenhauer B. Mov Disord. 2021 Aug;36(8):1972-1978. doi: 10.1002/mds.28608. Epub 2021 May 4. PMID: 33942926

Multivariate prediction of dementia in Parkinson's disease.
Phongpreecha T, Cholerton B, Mata IF, Zabetian CP, Poston KL, Aghaeepour N, Tian L, Quinn JF, Chung KA, Hiller AL, Hu SC, Edwards KL, Montine TJ. NPJ Parkinsons Dis. 2020 Aug 25;6(1):20. doi: 10.1038/s41531-020-00121-2. PMID: 34429432

Semantic fluency and processing speed are reduced in non-cognitively impaired participants with Parkinson's disease.
Cholerton BA, Poston KL, Yang L, Rosenthal LS, Dawson TM, Pantelyat A, Edwards KL, Tian L, Quinn JF, Chung KA, Hiller AL, Hu SC, Montine TJ, Zabetian CP. J Clin Exp Neuropsychol. 2021 Jul;43(5):469-480. doi: 10.1080/13803395.2021.1927995. Epub 2021 Aug 6. PMID: 34355669

International Multicenter Analysis of Brain Structure Across Clinical Stages of Parkinson's Disease.
Laansma MA, Bright JK, Al-Bachari S, Anderson TJ, Ard T, Assogna F, Baquero KA, Berendse HW, Blair J, Cendes F, Dalrymple-Alford JC, de Bie RMA, Debove I, Dirkx MF, Druzgal J, Emsley HCA, Garraux G, Guimarães RP, Gutman BA, Helmich RC, Klein JC, Mackay CE, McMillan CT, Melzer TR, Parkes LM, Piras F, Pitcher TL, Poston KL, Rango M, Ribeiro LF, Rocha CS, Rummel C, Santos LSR, Schmidt R, Schwingenschuh P, Spalletta G, Squarcina L, van den Heuvel OA, Vriend C, Wang JJ, Weintraub D, Wiest R, Yasuda CL, Jahanshad N, Thompson PM, van der Werf YD; ENIGMA-Parkinson's Study. Mov Disord. 2021 Nov;36(11):2583-2594. doi: 10.1002/mds.28706. Epub 2021 Jul 20. PMID: 34288137

The effects of mood and cognition on daily functioning and quality of life in older people living with HIV and people with Parkinson's disease.
Patel SS, Müller-Oehring EM, DeVaughn S, Fama R, Brontë-Stewart HM, Poston KL, Schulte T. Neuropsychology. 2021 Oct;35(7):691-705. doi: 10.1037/neu0000760. Epub 2021 Jul 29. PMID: 34323563

Mnemonic Similarity Task to study episodic memory in Parkinson's disease.
Das T, Kim N, McDaniel C, Poston KL. Clin Park Relat Disord. 2020 Jun 3;3:100062. doi: 10.1016/j.prdoa.2020.100062. eCollection 2020. PMID: 34316643

Substantia Nigra Volume Dissociates Bradykinesia and Rigidity from Tremor in Parkinson's Disease: A 7 Tesla Imaging Study.
Poston KL, Ua Cruadhlaoich MAI, Santoso LF, Bernstein JD, Liu T, Wang Y, Rutt B, Kerchner GA, Zeineh MM. J Parkinsons Dis. 2020;10(2):591-604. doi: 10.3233/JPD-191890. PMID: 32250317

MRI biomarkers of motor and non-motor symptoms in Parkinson's disease.
Ryman SG, Poston KL. Parkinsonism Relat Disord. 2020 Apr;73:85-93. doi: 10.1016/j.parkreldis.2019.10.002. Epub 2019 Oct 10. PMID: 31629653 Free PMC article. Review.

Cognitive impairment in Parkinson's disease is associated with Default Mode Network subsystem connectivity and cerebrospinal fluid Aβ.
Zarifkar P, Kim J, La C, Zhang K, YorkWilliams S, Levine TF, Tian L, Borghammer P, Poston KL. Parkinsonism Relat Disord. 2021 Feb;83:71-78. doi: 10.1016/j.parkreldis.2021.01.002. Epub 2021 Jan 12. PMID: 33484978