Pollack Lab: Translational Genomics
DEPARTMENT: Pathology
LOCATION: Center for Clinical Sciences Research (CCSR-3240)
OTHER AFFILIATIONS: Cancer Biology Program, Bio-X Program
Research Synopsis:
Research in the Pollack lab centers on translational genomics, with a focus on prostate diseases. The lab employs next-generation sequencing, single-cell and spatial genomics, gene editing, and human cell/tissue-based modeling to uncover disease mechanisms, biomarkers and therapeutic targets. Current major areas of emphasis include: (1) Determining disease mechanisms and new therapeutic targets in benign prostatic hyperplasia (BPH); (2) Defining molecular features of prostate cancer that distinguish indolent from aggressive disease; and (3) Discovering disease drivers in rare and neglected cancer types (e.g., ameloblastoma, liposarcoma).
Pollack lab in the news: Genes implicated in prostate enlargement
Pollack lab in the news: Genetic mishap behind rare white California poppies