Pollack Lab: Translational Cancer Genomics


LOCATION: Center for Clinical Sciences Research (CCSR-3240)

OTHER AFFILIATIONS: Cancer Biology Program, Bio-X Program

Research Synopsis:

Research in the Pollack lab centers on translational genomics, with a focus on human cancer. The lab employs next-generation sequencing, single-cell genomics, genome editing, and cell/tissue-based modeling to uncover disease mechanisms, biomarkers and therapeutic targets. Current areas of emphasis include: (1) Defining molecular features of prostate cancer that distinguish indolent from aggressive disease; (2) Determining disease mechanisms and new therapeutic targets in benign prostatic hyperplasia (BPH); and (3) Defining disease drivers in odontogenic neoplasms (e.g., ameloblastoma).