2018 Individual Seed Projects
Finding Novel Biomarkers in Human Sweat to Noninvasively Assess Risk and Progression of Metabolic Diseases Richard Zare, Michael Snyder, Robert Tibrishani
Determination of Sepsis Marker Levels in Pregnant Women During the Peripartum Period Natali Aziz, Ronald Gibbs, Samantha Do, Shanthi Kappagoda
- Women are vulnerable to infection in the peripartum period. Outside of pregnancy, markers such as lactate and procalcitonin are used to guide sepsis diagnosis and assess response to treatment. Normal levels of sepsis biomarkers in the peripartum period have not yet been determined. By establishing normal and elevated levels of sepsis markers in the peripartum period, the ability to rapidly diagnose severe maternal infections may greatly improve.
- Compare lactate and procalcitonin levels of infected to non-infected women in the peripartum period.
- Establish preliminary data for normal levels of lactate and procalcitonin in pregnant women in the peripartum period.
- Compare sepsis marker levels between 30 women with intraamniotic infection to 30 women without infection at 3 time points: the start of labor, immediately following delivery and 1 day postpartum.
Identifying Fibroblasts Subtypes Contributing to the Progression of Preinvasive to Invasive Lung Adenocarcinoma Sylvia Plevritis, Joseph Shrager, Gerlinde Wernig, Ann Leung, Matt van de Rijn
IgG Glycosylation as a Scalable Biomarker of Insulin Resistance and Metabolic Health Michael Snyder, Fahim Abbasi, Joshua Knowles
Automated Detection of Cerebral Ischemia to Reduce Disability and Mortality Paul Yock, Ross Venook, Jaime Lopez
Improving Abdominal Aortic Aneurysms Detection and Screening Oliver Aalami, Ronald Dalman, Todd Wagner
A Decision-Analytic Framework for Economic Evaluation of Current Precision Health Approaches and Prioritization of Their Future Research and Development Jeremy Goldhaber-Fiebert, Doug Owens, Joshua Salomon, Laurence Baker, Grace Lee, Kathryn Phillips, Jay Battacharya