2017 Individual Seed Projects
Utilizing the Immune Profile of Blood as a Biomarker for Transient Ischemic Attacks
Associate Professor of Anesthesiology, Perioperative and Pain Medicine (Adult-MSD) and, by courtesy, of Pediatrics (Neonatology)
Born in France, Dr. Gaudilliere studied Engineering at Ecole Polytechnique before completing an MD-PhD degree from the Harvard-MIT Health Sciences and Technology program and a postdoctoral fellowship at Stanford University (Dr. Garry Nolan laboratory). Research in the Gaudilliere lab combines high parameter mass cytometry (suspension and imaging mass cytometry) with other proteomics approaches to study how the human immune system responds and adapts to physiological or pathological stressors. Ongoing studies focus on several clinical scenarios including, 1) immune mechanisms of surgical recovery and complications (NIGMSR35), 2) pregnancy and preterm birth (NICHDP01, DDCF, BMGF, ITI, MOD), 3) immune dysfunction and outcomes prediction in patients with COVID19 (Fast Grant, CEND award). Dr. Gaudilliere is a Board-Certified Anesthesiologist and works clinically in the operating room 25% of his time.
- 300,000 people in the United States experience a TIA annually with over 10% suffering an ischemic stroke in the subsequent 90 days.
- No effective biomarker currently exists.
- Our approach identifies the immune profile of TIAs utilizing state of the art immune monitoring - Mass Cytometry by Time Of Flight Mass Spectrometry (CyTOF)
- Identification of these blood biomarkers will drastically change the current management of TIAs to prevent future strokes