As a non-invasive, non-ionizing and accessible imaging modality, ultrasound imaging has seen its clinical impact growing exponentially in the past thirty years. Clinical indications and reimbursement for therapeutic ultrasound are rapidly expanding. Yet, theragnostic technologies facilitating ultrasound guidance of ultrasound-mediated therapy are limited. In particular, 2D arrays that are capable of implementing and imaging ultrasound therapy are lacking. To propel the promise of the theragnostic treatment strategies forward, we have designed and tested a unique array and system for 3D ultrasound guidance of microbubble-based therapeutic protocols based on the frequency, temporal and spatial requirements.