Petritsch Lab Publications

Peer-reviewed journal articles (original research)

Ma, R., Gong, D., You, H., Xu, C., Lu, Y., Bergers, G., Werb, Z., Klein, O., Petritsch, C.K., Lu, P. LGL1 Binds to Integrin ß1 and Inhibits Downstream Signaling to Promote Collective Migration and Branching Morphogenesis in Mammary Gland Epithelium (2022) In Press, Cell Reports

Mueller, S., Jain, P., Liang, W.S., Kilburn, L., Kline, C., Gupta, N., Panditharatna, E., Magge, S.N., Zhang, B., Zhy, Y., Crawford, J.R., Banerjee, A., Nazemi, K., Packer, R.J., Petritsch, C.K., Truffaux, N., Roos, A., Nasser, S., Phillips, J.J., Solomon, D., Molinaro, A., Prados, M., Resnick., A.C. (2019). A pilot precision medicine trial for children with diffuse intrinsic pontine glioma – PNOC003: a report from the Pacific Pediatric Neuro-oncology Consortium. Int J Cancer [Epub ahead of print]

Daynac, M., Chouchane, M., Collins, H.Y., Murphy, N.E., Andor, N., Niu, J., Fancy, S.P., Stallcup, W., Petritsch, C.K. (2018). Lgl1 controls endocytosis to establish asymmetric cell division of oligodendrocyte progenitor cells and to suppress tumorigenesis. Nature Communications 9, 2862. PMCID:PMC6104045

Robson JP, Wagner B, Glitzner E, Heppner FL, Steinkellner T, Khan D, Petritsch C.K., Pollak DD, Sitte HH, Sibilia M. (2018). Impaired neural stem cell expansion and hypersensitivity to epileptic seizures in mice lacking the EGFR in the brain. FEBS J. 2018 Jul 20. PMID:30028091

Olow, A., Mueller, S., Yang, X., Hashizume, R., Meyerowitz, J., Weiss, W., Resnick, A.C., Waanders, A.J., Stalpers, L.J., Berger, M.S., Gupta, N., James, C.D., Petritsch, C.K., Haas-Kogan, D.A. (2016). BRAF status in personalizing treatment approaches for pediatric gliomas.  Clin Cancer Res 22, 5312-5321. PMCID: PMC5093033

Grossauer, S.*, Koeck, K.*, Meyers, I., Carrera, D., Berger, M.S., Okada, H., James, C.D., Petritsch, C.K. (2016). A novel immunocompetent mouse model of malignant astrocytoma is responsive to pharmacologic BRAFV600E inhibition.  Oncotarget 15, 75839. *equal contribution. PMCID:PMC5342782.

Andor, N, Graham, T.A., Jansen, M., Xia, L.C., Aktipis, C.A., Petritsch, C.K., Ji, H.P.*, Maley, C.C.* (2016). Pan-cancer analysis of the extent and consequences of intra-tumor heterogeneity. Nature Medicine 22, 105. *equal contribution. PMCID:PMC4830693

Lerner R.G.*, Grossauer S.*,  Kadkhodaei B., Meyers I., Sidorov M., Koeck K., Hashizume R., Ozawa T., Phillips J.J., Berger M.S., Nicolaides T., James C.D., Petritsch C.K. (2015). Targeting a Plk1-controlled polarity checkpoint in therapy-resistant glioblastoma-propagating cells. Cancer Research 75, 5355. *equal contribution. PMCID:PMC4698003
AACR Journal Editor’s pick 2015.

Bakhoum S.F., Kabeche L., Wood M.D., Laucius C.D., Qu D., Laughney A.M., Reynolds G.E., Louie R.J., Phillips J., Chan D.A., Zaki B.I., Murnane J.P., Petritsch C.K.*, Compton D.A.* (2015). Numerical chromosomal instability mediates susceptibility to radiation treatment. Nature Communication 6, 5990. *equal contribution.  PMID25606712. PMCID:PMC4516720

Hashizume R, Andor N, Ihara Y, Lerner R, Gan H, Chen X, Fang D, Huang X, Tom MW, Ngo V, Solomon D, Mueller S, Paris PL, Zhang Z, Petritsch C.K., Gupta N, Waldman TA, James CD. (2014). Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma. Nat Med. Nov 17. PMID: 25401693. PMCID: PMC4257862

Berberoglu MA, Dong Z, Li G, Zheng J, Trejo Martinez Ldel C, Peng J, Wagle M, Reichholf B, Petritsch C.K., Li H, Pleasure SJ, Guo S. (2014). Heterogeneously Expressed fezf2 Patterns Gradient Notch Activity in Balancing the Quiescence, Proliferation, and Differentiation of Adult Neural Stem Cells. J Neurosci. Oct 15; 34(42):13911-23. PMID: 25319688. PMCID: PMC4198537

Andor N, Harness JV, Müller S, Mewes HW, Petritsch C.K. (2014). EXPANDS: expanding ploidy and allele frequency on nested subpopulations. Bioinformatics. Jan 1; 30(1):50-60. PMID: 24177718. PMCID: PMC3866558

Huillard, E.*, Hashizume, R.*, Phillips, J.J. Griveau, A., Ihrie, R. I., Aoki, Y., Nicolaides T., Perry, A., Waldman, T., McMahon, M., Weiss, W. A., Petritsch, C.K., James, C. D., Rowitch, D. (2012). Cooperative interactions of BRAFV600E and CDKN2A deficiency in pediatric malignant astrocytoma as a basis for rational therapy. PNAS 22, 8710. *authors contributed equally. PMCID:PMC3365162

Sugiarto, S., Persson, A., Gonzalez-Munoz, E., Waldhuber, M., Lamagna, C., Hanecker, P., Philips, J., Vandenberg, S., Berger, M. S., Stallcup, W., Bergers, G., Weiss, W. A., Petritsch, C.K. (2011) Asymmetry-defective oligodendrocyte progenitors as glioma precursors. Cancer Cell 20, 328. PMCID: PMC3297490

Ouyang, Y., Petritsch, C.K., Jan, L.Y., Jan, Y.N., Lu, B. (2010). Dronc caspase exerts a non-apoptotic function to restrain phospho-Numb induced ectopic neuroblast formation in Drosophila. Development 11, 2185. PMICD:PMC3091490

Persson, A., Petritsch, C.K., Itsara, M., Swartling, F., Goldenberg, D., Vandenberg, S., Ngyuen, K., Yakovenko, S., Thorne, C.A., Lee, E., Nishiyama, A., Stallcup, W., Berger, M.S., Goldman, S., Bergers, G., Weiss, W.A. (2010). Non-stem cell origin of oligodendondrogliomas. Cancer Cell 6, 669. PMICD:PMC3031116

Erben, V., Waldhuber, M, Langer, D., Fetka, I, Jansen, R. P., Petritsch, C.K. (2008). Asymmetric localization of the adaptor protein Miranda is achieved by diffusion and sequential interaction of Myosin II and VI. Journal of Cell Science 121, 1401.

Du, R.*, Lu, K.*, Petritsch, C.K., Liu, P., Ganss, R., Passague, E., Song, H., VandenBerg, S., Werb, Z., Bergers, G. (2008). Hif1a induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion. *authors contributed equally, Cancer Cell 3, 206. PMCID: PMC2643426

Silber, J., Lim, D.A., Petritsch, C.K.*, Maunakea, A. K.*, Persson, A.*, Yu, M., Vandenberg, S., Ginzinger, D. G., James, C. D., Costello, J. F., Weiss, W. A., Bergers, G., Alvarez-Buylla, A., Hodgson, G. (2008). miR-124a and miR-137 inhibit proliferation of GBM cells and induce differentiation of tumor stem cells. *authors contributed equally, BioMedCentral Medicine 6, 14. PMCID: PMC2443372

Du, R., Petritsch, C.K., Ganss, R., Song, H., Vandenberg, S., Bergers, G. (2008). Matrix metalloproteinase 2 regulates tumor cell survival, invasion and vascular branching in GBM. Neuro-oncology 3, 254. PMCID: PMC2563048

Waldhuber, M., Emoto, K. and Petritsch, C.K. (2005). Drosophila caspase DRONC is required for metamorphosis and cell death in response to irradiation and developmental signals. Mechanisms in Development 122, 914.

Ye, B, Petritsch, C.K., Clark, I. E., Gavis, E. R., Jan, L.Y. and Jan, Y.N. (2004). Nanos and pumilio are essential for  dendrite morphogenesis in Drosophila peripheral neurons. Current Biology 14, 314.

Petritsch, C.K.,Tavosanis, G., Turck, C.W., Jan, L.Y. and Jan, Y.N. (2003). The Drosophila myosin VI Jaguar controls spindle orientation and basal determinant targeting in mitotic neuroblasts. Developmental Cell 4, 273.

Petritsch, C.K., Beug, H., Balmain, A. and Oft, M. (2000). TGFbeta inhibits p70 S6 Kinase via Protein Phosphatase 2A to induce G1 arrest. Genes & Development 14, 3093. PMCID: PMC317138

Peer-reviewed publications other

Lerner RG, Petritsch C. A microRNA-operated switch of asymmetric-to-symmetric cancer stem cell divisions. (2014). Nat Cell Biol. Feb 28; 16(3):212-4. PMID: 24576899. Comment on MicroRNA-146a directs the symmetric division of Snail-dominant colorectal cancer stem cells. [Nat Cell Biol. 2014]

Gómez-López S, Lerner RG, Petritsch C.K.. (2014). Asymmetric cell division of stem and progenitor cells during homeostasis and cancer. Cell Mol Life Sci. Feb; 71(4):575-97. PMID: 23771628. PMCID: PMC3901929.

Wade, A., Robinson, A.E., Engler, J.R., Petritsch, C., James, C.D., Phillips, J.J. (2013). Proteoglycans and their role in brain cancer. FEBS J 280, 2399. PMCID:PMC3644380

Non peer-reviewed journal articles

Lewis, K.M., Petritsch, C.K. (2013). Asymmetric Cell Division: Implications for glioma development and treatment.  Translational Neuroscience 4, 484. PMCID:PMC4269374

Book chapters

Daynac M., Petritsch, C.K. (2017). Regulation of Asymmetric Cell Division in Mammalian Neural Stem and Cancer Precursor Cells. Springer Press. Results Probl Cell Diff 61, 375-399

Petritsch, C.K. and Shen, X. (2015). Asymmetric Cell Division of Cancer Stem Cells.  Book Chapter. Elsevier Press.  Cancer Stem Cells.

Petritsch, C.K. & Vandenberg, S. R.: „Stem and Progenitor Cell Lineages as Targets for Neoplastic Transformation in the Central Nervous System." Chapter 2, "Brain Tumors: An encyclopedic approach." Edited by Kay A.H. & Laws, E.R.,   3rd edition.