Knowles Lab Publications

Check out our recent publication in Nature Neuroscience on maladaptive myelination in generalized epilepsy and related commentary! 

Chau Loo Kung G, Knowles JK, Batra A, Ni L, Rosenberg J, McNab JA. Quantitative MRI reveals widespread, network-specific myelination change during generalized epilepsy progression. Neuroimage (2023). https://doi.org/10.1016/j.neuroimage.2023.120312.

Knowles JK, Batra A, Xu H, Monje M. Adaptive and maladaptive myelination in health and disease. Nat Rev Neurol (2022). https://doi.org/10.1038/s41582-022-00737-3

Revah O, Gore F, Kelley KW, Andersen J, Sakai N, Chen X, Li MY, Birey F, Yang X, Saw NL, Baker SW, Amin ND, Kulkarni S, Mudipalli R, Cui B, Nishino S, Grant GA, Knowles JK, Shamloo M, Huguenard JR, Deisseroth K, Pașca SP. Maturation and circuit integration of transplanted human cortical organoids.  Nature. 2022 Oct;610(7931):319-326. doi: 10.1038/s41586-022-05277-w. Epub 2022 Oct 12. PMID: 36224417

Knowles JK, Helbig I, Metcalf CS, Lubbers LS, Isom LL, Demarest S, Goldberg E, George AL Jr, Lerche H, Weckhuysen S, Whittemore V, Berkovic SF, Lowenstein DH. Precision medicine for genetic epilepsy on the horizon: recent advances, present challenges and suggestions for continued progress. Epilepsia. 2022 Jun 18. doi: 10.1111/epi.17332. Online ahead of print. PMID: 35716052 Review. 

Knowles JK, Xu H, Soane C, Batra A, Saucedo T, Frost E, Tam LT, Fraga D, Ni L, Villar K, Talmi S, Huguenard JR, Monje M. Maladaptive myelination promotes generalized epilepsy progression. Nat Neurosci. 2022 May 2. doi: 10.1038/s41593-022-01052-2. Online ahead of print. PMID: 35501379  

Knowles JK, Porter BE. Practical Advice on Surviving and Thriving as an Academic Physician-Neuroscientist. JAMA Neurol. 2021 Dec 1;78(12):1439-1440. doi: 10.1001/jamaneurol.2021.3889. PMID: 34694341

Pavitt S, Carley A, Porter B, Knowles JK. A Standardized Protocol to Improve Acute Seizure Management in Hospitalized Pediatric Patients. Hosp Pediatr. 2021 Apr;11(4):389-395. doi: 10.1542/hpeds.2020-000968. Epub 2021 Mar 8. PMID: 33685859

Shellhaas RA, deVeber G, Bonkowsky JL; Child Neurology Society Research Committee. Gene-Targeted Therapies in Pediatric Neurology: Challenges and Opportunities in Diagnosis and Delivery. Pediatr Neurol. 2021 Dec;125:53-57. doi: 10.1016/j.pediatrneurol.2021.09.011. Epub 2021 Sep 25. PMID: 34628144

Knowles JK, Xu H, Batra A, Soane C, Frost E, Tam L, Fraga D, Villareal K, Saucedo T, Huguenard J, Monje M. Maladaptive Myelination Contributes to Absence Seizure Progression.   

Sandoval Karamian AG, Wusthoff CJ, Boothroyd D, Yeom KW, Knowles JK. Neonatal genetic epilepsies display convergent white matter microstructural abnormalities. Epilepsia, 2020. PMID: 33098118.

Knowles JK, Santoro JD, Porter BE, Baumer FM. Refractory focal epilepsy in a paediatric patient with primary familial brain calcification. Seizure, February 2018. PMID: 29448117.

Simmons DA, Knowles JK, Belichenko NP, Banerjee G, Finkle C, Massa SM, Longo FM. A small molecule p75NTR ligand, LM11A-31, reverses cholinergic neurite dystrophy in Alzheimer's disease mouse models with mid- to late-stage disease progression. PLoS One, August 2014.  PMID: 25153701.

Knowles JK, Simmons DA, Nguyen T-V, Vander Griend L, Xie Y, Zhang H, Yang T, Pollak J, Chang T, Arancio O, Buckwalter M, Wyss-Coray T, Massa SM, Longo FM. A small molecule p75^NTR ligand prevents cognitive deficits and neurite degeneration in an Alzheimer’s mouse model. Neurobiology of Aging, August 2013. PMID 23545424. 

Knowles JK, Rajadas J, Vander Griend L, Ishikawa C, Nguyen T, LeMieux M, Wyss-Coray T, Longo FM. The p75  neurotrophin receptor promotes amyloid-b(1-42) induced neuritic dystrophy in vitro and in vivo. The Journal of Neuroscience, August 2009. PMID 19710315.

Yang T*, Knowles JK*, Lu Q, Zhang H, Arancio O, Moore L, Chang T, Wang Q, Andreasson K, Rajadas J, Fuller G, Xie Y, Massa SM, Longo FM. Small molecule, non-peptide p75^NTR ligands inhibit Aβ-induced neurodegeneration and synaptic impairment. PLoS One, October 2008. PMID 18978948.

Prip-Buus C, Thuillier L, Abadi N, Prasad C, Dilling L, Klasing J, Demaugre F, Greenberg CR, Haworth JC, Droin V, Kadhom N, Gobin S, Kamoun P, Girard J, Bonnefont JP. Molecular and enzymatic characterization of a unique carnitine palmitoyltransferase 1A mutation in the Hutterite community. Molecular Genetics and Metabolism, May 2001. PMID 11350182.

Knowles JK, Wusthoff CJ. Quantitative EEG in Neonatal Seizures. In: Husain A, Sinha S (eds) Continuous EEG Monitoring. Springer, 2017.

Knowles JK, Penn AA. Perinatal Brain Development, Malformation and Injury. Morgan and Claypool Life Sciences Colloquium Series on the Developing Brain, 2012.

Longo FM, Yang T, Knowles JK, Xie Y, Moore LA, Massa SM. Small molecule neurotrophin receptor ligands: novel strategies for targeting Alzheimer's disease mechanisms. Current Alzheimer Research, 2007. PMID 18220511.