2020
8:00 AM - 3:30 PM
Thursday Thu
ABSTRACT DEADLINE
January 15, 2020
NOTIFICATION OF ACCEPTED ABSTRACTS
February 2020
EVENT REGISTRATION OPENS
March 2020
RESEARCH RETREAT - EVENT CANCELLED!
April 23, 2020 (Thursday)
CANCELED: 11th Annual Pediatrics Research Retreat
LKSC Conference Center, Berg Hall
This event has been canceled. We apologize for the inconvenience.
DEPARTMENT EVENT UPDATE RELATED TO NOVEL CORONAVIRUS (COVID-19)
Dear Pediatrics Faculty, Fellows, Residents, Postdocs, Students, and Staff,
In light of the University’s guidance around social distancing, we have decided to cancel the 11th Annual Pediatrics Research Retreat, scheduled for Thursday, April 23. We know that this news is a great disappointment to many in our community. We are grateful to all of the faculty speakers, trainee speakers, and poster presenters who planned to share their scholarship in Pediatrics.
This change is being implemented to promote the University’s teaching and research mission while taking measures to prevent the spread of the COVID-19 disease and ensure the well-being of our campus and community. We encourage you to visit healthalerts.stanford.edu for the latest updates from Stanford about its response to COVID-19.
We will begin planning for our 2021 Pediatrics Research Retreat in the fall. In the interim, we are looking into ways we can highlight the breadth and depth of scholarly projects that our community has completed over the past year, and will send out more information on those initiatives once they have been finalized.
Thank you for your understanding and flexibility as we work to address this evolving issue.
Sincerely,
Pediatrics Research Retreat Committee
07:30AM - 07:50AM
Event Check-in & Continental Breakfast
WELCOME
08:00AM - 08:10AM
Mary Leonard, MD, MSCE (Department Chair)
SESSION ONE
Moderator: Julien Sage, PhD (Faculty, Pediatric Hematology/Oncology)
08:10AM - 08:35AM
Literacy and Health: Evidence to Inform Maternal and Child Health
Lee Sanders, MD, MPH (Faculty, General Pediatrics)
08:35AM - 08:50AM
Development of a Hematopoietic Stem Cell-Based Therapy for Gaucher Disease
Marc Gastou, PhD (Postdoc, Medical Genetics)
08:50AM - 09:15AM
Learning New Tricks From Cone Snails: An Insulin Story
Danny Chou, PhD (Faculty, Pediatric Endocrinology)
KEYNOTE
09:15AM - 10:15AM
From Cognition to Cancer: Myelin Plasticity in Health and Disease
Michelle Monje, MD, PhD (Faculty, Neurology)
POSTER SESSION
10:15AM - 11:15AM
SESSION TWO
Moderator: Anisha Patel, MD, MSPH, MSHS (Faculty, General Pediatrics)
11:15AM - 11:40AM
Cracking the Code on the Complication of Pancreatitis Due to the Anti-Leukemic Drug Asparaginase
Sohail Husain, MD (Faculty, Pediatric Gastroenterology)
11:40AM - 11:55AM
Selection of Adeno-Associated Virus Vectors Targeting the Central Nervous System Using an In Vitro Model of Human Blood-Brain Barrier
Ren Song, PhD (Postdoc, Human Gene Therapy)
11:55AM - 12:10PM
The Effect of Stenosis Formation and Intimal Thickening on Tissue Engineered Vascular Graft Hemodynamic
Stephanie Lindsey, PhD (Postdoc, Pediatric Cardiology)
12:10PM - 12:35PM
Coaching Learners to Enhance Performance
Becky Blankenburg, MD, MPH & Carrie Rassbach, MD, MAEd (Faculty, Pediatric Hospital Medicine)
POSTER SESSION & LUNCH
12:35PM - 01:15PM
SESSION THREE
Moderator: Seda Tierney, MD (Faculty, Pediatric Cardiology)
01:15PM - 01:30PM
Polygenic Architecture of Computationally Derived Aortic Diameter Predicts the Risk for Aortic Aneurysm and Dissection
Catherine Tcheandjieu, DVM, PhD, MPH (Postdoc, Pediatric Cardiology)
01:30PM - 01:55PM
Developmental Heterogeneity of Pulmonary Endothelial Cells at Single Cell Resolution: Implications for Lung Development, Injury, and Repair
Cristina Alvira, MD (Faculty, Pediatric Critical Care Medicine)
01:55PM - 02:10PM
Defining the Neointima in an Inflammation Driven Model of Pulmonary Hypertension
Lea Steffes, MD (Fellow, Pediatric Pulmonology)
02:10PM - 02:35PM
Listen to Your Mother: A Randomized Clinical Trial of Maternal Speech Exposure on Structural Brain Connectivity in Preterm Newborns
Katherine Travis, PhD (Faculty, Developmental-Behavioral Pediatrics)
02:35PM - 3:00PM
Overcoming Barriers to Immunotherapy for Pediatric Solid Tumors
Robbie Majzner, MD (Faculty, Pediatric Hematology/Oncology)
ABSTRACT & POSTER AWARDS
03:00PM - 03:15PM
Mary Leonard, MD, MSCE (Department Chair) & Gary Shaw, DrPH (Associate Chair of Research)
SESSION ONE
08:10AM - 08:35AM
Literacy and Health: Evidence to Inform Maternal and Child Health - Lee Sanders, MD, MPH (Faculty, General Pediatrics)
-How does literacy influence health?
-What are the essential features of a “health-literate” system of care?
08:35AM - 08:50AM
Development of a hematopoietic stem cell-based therapy for Gaucher disease - Marc Gastou, PhD (Postdoc, Medical Genetics)
-Developing a safe and effective one-time therapy for Gaucher patients?
-Establish murine models of Gaucher disease amenable to human cell transplantation
-Mechanisms underlying the association of mutations found Gaucher disease and increased of risk for Parkinson disease.
08:50AM - 09:15AM
Learning New Tricks From Cone Snails: An Insulin Story - Danny Chou, PhD (Faculty, Endocrinology)
- How can we help people with diabetes to achieve optimal blood glucose control with minimal efforts?
KEYNOTE
09:15AM - 10:15AM
From Cognition to Cancer: Myelin Plasticity in Health and Disease - Michelle Monje, MD, PhD (Faculty, Neurology)
Neuronal activity regulates the proliferation and differentiation of oligodendrocyte precursor cells during development and as an ongoing mechanism of neural adaptation. In the healthy brain, this results in activity-regulated plasticity of myelin structure and consequent modulation of neural circuit function that contributes to attention, learning and memory. The robust influence of neuronal activity on normal oligodendroglial precursor cells, a putative cellular origins of pediatric high-grade gliomas, suggests that dysregulated or “hijacked” mechanisms of myelin plasticity might similarly promote proliferation in this devastating group of childhood brain cancers. Concordantly, neuronal activity drives glioma progression through activity-regulated secreted growth factors and through direct electrical signaling between neurons and gloom cells that structurally and electrically integrate into neural circuits. Targeting neuron-glioma interactions represents an important therapeutic target in glial malignancies of childhood.
SESSION TWO
11:15AM - 11:40AM
Cracking the Code on the Complication of Pancreatitis Due to the Anti-Leukemic Drug Asparaginase - Sohail Husain, MD (Faculty, Gastroenterology)
- What drives the pancreas to become inflamed with varying triggers, and, conversely, what protects the protect from becoming inflamed in most people?
- What are the cues that trigger the pancreas, and, on a broader level, organs, to recover and regenerate after injury?
- How can we harness this information to prevent organ inflammation and promote recovery and regeneration?
11:40AM - 11:55AM
Selection of Adeno-Associated Virus Vectors Targeting the Central Nervous System Using an In Vitro Model of Human Blood-Brain Barrier - Ren Song, PhD (Postdoc, Human Gene Therapy)
- Selection of Adeno-associated Virus Vectors Targeting the Central Nervous System Using an in vitro Model of Human Blood-brain Barrier
- Can we create and isolate rAAV vectors with enhanced ability to penetrate the human BBB and systematically deliver gene therapy to the CNS?
- Will these rAAV vectors also be able to transduce specific cell types in the CNS so that gene therapy can be targeted to specific diseases?
11:55AM - 12:10PM
The Effect of Stenosis Formation and Intimal Thickening on Tissue Engineered Vascular Graft Hemodynamic - Stephanie Lindsey, PhD (Postdoc, Pediatric Cardiology)
- What is the role that hemodynamics plays in scaffold degradation and neovessel formation?
- How does the local mechanical environment influence the body's immune response or the accumulation of monocytes?
12:10PM - 12:35PM
Coaching Learners to Enhance Performance - Becky Blankenburg, MD, MPH & Carrie Rassbach, MD, MAEd (Faculty, Hospital Medicine)
- How can coaching be used to optimize learner performance?
- What are the impacts of coaching on learners and faculty?
SESSION THREE
01:15PM - 01:30PM
Polygenic Architecture of Computationally Derived Aortic Diameter Predicts the Risk for Aortic Aneurysm and Dissection - Catherine Tcheandjieu, PhD (Postdoc, Pediatric Cardiology)
- How can we combine machine learning and genomics to better understand the genetic architecture heart anatomy, predict the risk of aortic disease, and better understand which risk factors are causal for disease
01:30PM - 01:55PM
Developmental Heterogeneity of Pulmonary Endothelial Cells at Single Cell Resolution: Implications for Lung Development, Injury, and Repair
Cristina Alvira, MD (Faculty, Critical Care Medicine)
01:55PM - 02:10PM Defining the Neointima in an Inflammation Driven Model of Pulmonary Hypertension - Lea Steffes, MD (Fellow, Pediatric Pulmonology)
-What cellular signals drive the neointimal formation and proliferation seen in pulmonary vascular disease?
-Is the transcriptomic signature of a neointimal cell different from that of their smooth muscle cell progenitors?
02:10PM - 02:35PM
Listen to Your Mother: A Randomized Clinical Trial of Maternal Speech Exposure on Structural Brain Connectivity in Preterm Newborns - Katherine Travis, PhD (Faculty, Developmental-Behavioral Pediatrics)
- How does brain development contribute to language learning in infants and young children?
- How do early life experiences contribute to brain development and neurocognitive outcomes in children?
02:35PM - 3:00PM
Overcoming Barriers to Immunotherapy for Pediatric Solid Tumors - Robbie Majzner, MD ( Faculty, Hematology/Oncology)
- The immune response in pediatric cancer is very different than in adult malignancies - how can we manipulate the immune system of children to defeat pediatric cancers?
- CAR T cells rely on synthetic receptors that were generated to mimic the natural T cell receptor but behave very differently – how can we generate receptors that are well suited for killing tumors but sparing normal tissues.
KEYNOTE SPEAKER
Michelle Monje, MD, PhD
Michelle Monje, MD, PhD, is a physician-scientist studying the molecular and cellular mechanisms of postnatal neurodevelopment and neuroplasticity at the intersection of neuroscience and pediatric brain tumor biology. Her scientific training is in the field of neural development, with an emphasis on glial biology and cell signaling. Her research program focuses on gliomas such as glioblastoma and diffuse intrinsic pontine glioma (DIPG) and the microenvironmental determinants of normal and malignant neural precursor cell behavior. Microglial influences on normal neural precursor cell function and the impact of microglial neuroinflammation following cancer therapies on cellular mechanisms of neuroplasticity and brain homeostasis is one area of deep focus (Monje et al, 2002, Nature Medicine, Monje et al, 2003, Science, Monje et al, 2007, Annals of Neurology, Gibson et al., 2019 Cell; Geraghty et al, 2019 Neuron). The regulation of normal and malignant glial cells by neuronal activity is another area of particular emphasis (Gibson et al., 2014, Science; Venkatesh et al., 2015, Cell; Geraghty et al, 2019 Neuron) and her research group is working to decipher and therapeutically target the molecular mechanisms that underlie neuronal interactions with gliomas (Venkatesh et al, 2017, Nature; Venkatesh et al., 2019 Nature). In addition to these studies of mature neurons in the glioma microenvironment, we also study the influences of neural precursor cells on glioma (Qin et al., 2017, Cell). Together with these basic studies, her research program executes preclinical studies of novel therapeutics for high-grade gliomas (Grasso et al, 2015, Nature Medicine; Nagaraja et al, 2017, Cancer Cell; Mount et al, 2018 Nature Medicine; Lin et al, 2019 Science Translational Medicine) in order to translate new therapies to the clinic for glial cancers. Stanford CAP Profile
Faculty Speakers
Cristina Alvira, MD
ASSOCIATE PROFESSOR, PEDIATRIC CRITICAL CARE MEDICINE
- Tashia and John Morgridge Faculty Scholar in Pediatric Translational Medicine, Stanford Child Health Research Institute
- NIH-funded basic research program aimed at identifying novel mechanisms that direct lung growth and repair in infants and children
- Member, Society for Pediatric Research
- Editorial Board, American Journal of Physiology-Lung, Cellular and Molecular Physiology
Becky Blankenburg, MD, MPH
CLINICAL PROFESSOR, PEDIATRIC HOSPITAL MEDICINE
- Recognized for helping develop and study the first Pediatrics Residency Coaching Program and Residency Scholarly Concentration Program in the country
- Conducted research focused on improving resident learning in the clinical learning environment
- President of the Association of Pediatric Program Directors
Danny Hung-Chieh Chou, PhD
ASSISTANT PROFESSOR, PEDIATRIC ENDOCRINOLOGY
- Work from my lab has broadened the scope of insulin analog design for future diabetes treatments
- Trainees in my lab have received prestigious recognitions, which includes JDRF Postdoc Fellowship, American Diabetes Association Postdoctoral Fellowship and Merck Research Award from American Chemical Society
Sohail Husain, MD
PROFESSOR, PEDIATRIC GASTROENTEROLOGY
- We discovered that a calcium-activated pathway is crucial to the onset of pancreatitis due to specific, intervenable triggers?
- We discovered several gene signatures that could be responsible for turning off the regenerative capacity of the pancreas
- We are closer to determining the mechanisms by which asparaginase predisposes users to pancreatitis
Robbie Majzner, MD
ASSISTANT PROFESSOR, PEDIATRIC HEMATOLOGY/ONCOLOGY
- Published preclinical studies on the first effective CAR T cell therapy for Diffuse Intrinsic Pontine Glioma, a universally fatal childhood brain tumor which is opening as a clinical trial at Stanford in the next few months
- Generated preclinical data on the combination of anti-GD2 and anti-CD47 therapy that we are now actively translating to a clinical trial for children with neuroblastoma and osteosarcoma
Michelle Monje, MD, PhD
ASSOCIATE PROFESSOR, NEUROLOGY
- NIH Director's Pioneer Award, NIH
- Neuro-Oncology Investigator Award, American Academy of Neurology
Carrie Rassbach, MD, MAEd
CLINICAL PROFESSOR, PEDIATRIC HOSPITAL MEDICINE
- Recognized for developing and studying the first Pediatrics Residency Coaching Program in the country
- Launched Stanford’s inaugural Pediatric Hospital Medicine Fellowship Program
- Conducted research focused on improving resident and fellowship training and education
Lee Sanders, MD, MPH
CHIEF, GENERAL PEDIATRICS
- Discovery and Team Science: Advancing a new scientific field, Pediatric Health Literacy, with funding from the Robert Wood Johnson Foundation, the National Institutes of Health, the National Science Foundation, the Centers for Disease Control and Prevention, the Patient Centered Outcomes Research Institute, and the Food and Drug Administration. Collaborators include leading scholars from the social sciences, as well as partnerships across multiple academic institutions.
- Service and Advocacy: Supporting national efforts to highlight health literate solutions – in partnership with the Academic Pediatric Association, the American Academy of Pediatrics, and the CDC. Scaling the Reach Out and Read model regionally and nationally – in partnership with regional agencies, including schools, libraries and departments of education.
- Mentorship: Guiding more than 50 trainees to develop their own scholarship, with innovative and rigorous approaches to addressing disparities in child health. Many of these trainees have gone on to their own independent careers – leading research, public policy or care systems.
Katherine Travis, PhD
ASSISTANTPROFESSOR, DEVELOPMENTAL-BEHAVIORAL PEDIATRICS
- Society for Developmental and Behavioral Pediatrics Young Investigator Award
- NIH-NICHD K99/R00 Pathway to Independence Award
- Becoming Research Faculty at Stanford
Marc Gastou, PhD
POSTDOCTORAL SCHOLAR, MEDICAL GENETICS
- Thesis focused on understanding the pathophysiological mechanisms of a rare disease: Diamond-Blackfan anemia (DBA). DBA is a pleiotropic disease caused by different mutations mainly localized in genes encoding ribosomal proteins. Successfully demonstrated that HSP70 protein is the key modulator of the severity of DBA. Studied the metabolism of heme and iron in DBA and showed a major defect in the synthesis of globins resulting in an increase of the amount of free heme that can be modulated by the expression level of HSP70.
- Participated in collaborative works within the EuroDBA consortium on the phenotypic characterization of patients carrying mutations in new genes causing DBA.
- Studied the mechanisms involved in the development of fibrosis and more particularly we have demonstrated that the transcription factor c-JUN/AP1 promotes different fibrotic conditions by acting on different molecular pathways.
Stephanie Lindsey, PhD
POSTDOCTORAL SCHOLAR, PEDIATRIC CARDIOLOGY
- Awarded individual research fellowships from the National Institute of Health, National Science Foundation, Alfred P. Sloan Foundation and Whitaker International Foundation
Ren Song, PhD
POSTDOCTORAL SCHOLAR, HUMAN GENE THERAPY
- 2017 Stanford University School of Medicine Dean’s Fellowship
- 2015 Outstanding Science Award of Department of Molecular Biology at Princeton University
- 2015 International Society for Neurovirology Pioneer in NeuroVirology Lectureship Award
- 2013 Graduate Research Funding for Global Health and/or Infectious Disease
Lea Steffes, MD
FELLOW, PEDIATRIC PULMONOLOGY
- Awarded intramural grant funding through the MCRHI and Pulmonary T32 to fund my second and third year of fellowship training
- Awarded an Excellence in Research Grant from the 2019 Neonatal Cardiopulmonary Young Investigator Forum.
- Submitted manuscript to a high impact vascular journal and recieved favorable reviews, pending publication
Catherine Tcheandjieu, DVM, PhD, MPH
POSTDOCTORAL SCHOLAR, PEDIATRIC CARDIOLOGY
- Giving oral presentation at the biggest human genetic conference (ASHG), defending my PhD with a great score
Poster Session Times & Location
Thursday, April 23, 2020 | LKSC Conference Center
- 10:15AM to 11:15AM Poster Session
- 12:35PM to 01:15PM Poster Session
Posters by Location:
- Posters 01 – 83: Berg Hall, Room A
- Posters 84 – 93: Berg Hall, Lobby
Poster Board Assignment List :
To be announced
REGISTRATION
All poster presenters must also register for the retreat.
EARLY POSTER DROP OFF
For your convenience, we will allow early poster drop off no later than Wednesday, April 22 before 3:00pm. Include your poster and name clearly marked on the outside of your poster. Drop off your poster at the Department of Pediatrics Chair’s Suite at room H310, East Pavilion, 3rd Floor, Stanford Hospital. If you miss the early drop off time, you will have access to the poster area on Thursday, April 23 between 7:30am and 9:45am.
If you have questions, please feel free to send an email to peds-education@stanford.edu.
POSTER PREPARATION
Posters will be on display in LKSC, 2nd Floor, Berg Hall on Thursday, April 23 between 10:15am and 3pm. The formal Poster Session where presenters must stand with their poster will be held from 10:15am-11:15am. Additional time for poster viewing will be during lunch from 12:35pm-1:15pm.
On April 23, you will have access to the poster area in Berg Hall, Room A and in the Lobby, between 7:30am and 9:45am to display your poster. Posters must be in place by 9:45am on April 23.
POSTER WINNERS & RECOGNITION
Poster finalists will be judged during the poster sessions. Winners will be determined by the end of lunch and notified. We will request winners to be available at 2:45pm for the Abstract & Poster winner acknowledgements.
POSTER SIZE
Posters will be limited to 44 inches high x 44 inches wide.
- Due to limited space, two poster presentations will be mounted to each side of the poster boards.
- Please follow size limits so you allow a space for a poster number in the upper corner of the board and avoid encroaching on your neighbor’s poster display.
- Each poster has been assigned a number for you to know where to place your poster
You are expected to stand with your poster during the Poster Sessions so that attendees may confer with you. Faculty, staff, community members, and other guests will be walking around the room asking questions and are eager to learn about your project. Come prepared to answer questions and explain your work.
You are responsible for removing your poster at the end of the event at 3:00pm.
Research Retreat Executive Committee
Research Retreat Event Planning Team
Submission Deadline January 15, 2020
Abstract Submission Form is Closed
All abstract submissions should include a trainee as the primary author. The trainee categories in Pediatrics include: Instructors, Fellows, Residents, Postdocs, and Students.
Oral abstract and poster submissions are due by 5pm on January 15, 2020.
We look forward to seeing you on Thursday, April 23, 2020.
If you have any questions about the submission process, please do not hesitate to contact us at peds-education@stanford.edu
Abstract Guidelines
We recommend that you prepare your abstract in a word processing application and then paste each component into the corresponding online section. Your abstract should not exceed 500 words. An abstract submission is considered a commitment to attend the retreat and present, if accepted.
Abstract decisions will be sent to the primary author in February 2020. All abstracts will undergo a review process by the Research Retreat Executive Committee reviewers. All abstracts should include a trainee as the primary author. The trainee categories in Pediatrics include: Instructors, Fellows, Residents, Postdocs, and Students.
Oral Presentations
Five trainees will be selected to present an oral presentation as part of the main agenda. Oral presentations include a short 10 minute overview of the research and 5 minutes for Q&A.Oral abstract and poster submissions are due by 5pm on January 15, 2020.
Poster Presentations
Poster presenters are expected to be available to discuss their research with session attendees during the poster sessions.
Oral abstract and poster submissions are due by January 15, 2020.