Presence of circular amplification associates with poor outcomes. Kaplan-Meier five-year survival curves by amplification category. Patients whose tumors contain at least one Circular ecDNA-based amplicon have significantly worse outcome compared to patients whose tumors were classified as non-circular. The p-value comparing survival curves was based on a log-rank test.

From the publication "Extrachromosomal DNA is associated with oncogene
amplification and poor outcome across multiple cancers"

Representative Publications

Extrachromosomal DNA in the cancerous transformation of Barrett’s oesophagus
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Extrachromosomal DNA is associated with oncogene amplification
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Targeted therapy resistance mediated by dynamic regulation
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Science 2014 Jan 3, doi:10.1126/science.1241328

mTOR complex 2 controls glycolytic metabolism in glioblastoma through
FoxO acetylation and upregulation of c-Myc

Masui, K., Tanaka, K., Akhavan, D., Babic, I., Gini, B., Matsutani, T., Iwanami, A., Liu, F., Villa, G. R., Gu, Y., Campos, C., Zhu, S., Yang, H., Yong, W. H., Cloughesy, T. F., Mellinghoff, I. K., Cavenee, W. K., Shaw, R. J. & Mischel, P. S.
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EGFR mutation-induced alternative splicing of Max contributes
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Babic, I., Anderson, E. S., Tanaka, K., Guo, D., Masui, K., Li, B., Zhu, S., Gu, Y., Villa, G. R., Akhavan, D., Nathanson, D., Gini, B., Mareninov, S., Li, R., Camacho, C. E., Kurdistani, S. K., Eskin, A., Nelson, S. F., Yong, W. H., Cavenee, W. K., Cloughesy, T. F., Christofk, H. R., Black, D. L. & Mischel, P. S.
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