Stanford Pathology in the News

COVID-19 severity affected by proportion of antibodies targeting crucial viral protein

Pathology Faculty in the news

A study co-authored by Scott Boyd found that people with severe COVID-19 have a lower proportion of antibodies targeting the coronavirus's spike protein than of antibodies targeting proteins of the virus’s inner shell.
Steve Fisch

A comprehensive study of immune responses to SARS-CoV-2 associates mild disease with comparatively high levels of antibodies that target the viral spike protein. But all antibodies wane within months.

COVID-19 antibodies preferentially target a different part of the virus in mild cases of COVID-19 than they do in severe cases, and wane significantly within several months of infection, according to a new study by researchers at Stanford Medicine.

The findings identify new links between the course of the disease and a patient’s immune response. They also raise concerns about whether people can be re-infected, whether antibody tests to detect ...