October 22 Oct 22
2024
012:00 PM - 01:00 PM
Tuesday Tue
IN PERSON, Li Ka Shing, LK130
Event

Pathology Grand Rounds: “Identification and Functionalization of Rare Noncoding Variants Driving Parkinson’s Disease Risk”

Robert Corces, PhD
Assistant Professor, Department of Neurology, University of California, San Francisco, CA; Assistant Investigator, Gladstone Institutes of Neurological Disease, Gladstone Institutes, San Francisco, CA

Location: Li Ka Shing, LK130

Lunch available at 11:45 AM and the lecture is at 12:00 PM.

The Pathology Grand Rounds is open to those affiliated with Stanford University Medical Center and invited guests only. The objective is to increase knowledge in the field of Pathology. There is no commercial support received for this course unless otherwise specified. Contact Annie Vo at annie.vo@stanford.edu or call 650-725-9352 for more information.

About the Speaker

My long-term research interests are centered on understanding how dysregulation of chromatin contributes to human disease. As each cell in the human body inherits the same genome, chromatin regulation and organization provides the layer of information beyond the genetic sequence that engenders every cellular function. These regulatory programs are highly cell type and cell context-specific and hold great promise to improve our understanding of disease and our ability to develop novel efficacious therapies.

During my doctoral training at Stanford University under the mentorship of Dr. Ravindra Majeti, I discovered and characterized a new class of cells that are the evolutionary ancestors to acute myeloid leukemia (Jan*, Snyder*, Corces* et al. Science Translational Medicine 2012 and Corces et al. PNAS 2014). The discovery of these cells, termed pre-leukemic hematopoietic stem cells, has changed the way that we think about leukemia evolution and treatment and has spurned the development of a new branch of leukemia biology that studies what has come to be known as “clonal hematopoiesis”. Importantly, this work identified patterns in mutation acquisition in leukemia, with mutations in genes regulating the epigenome almost universally occurring during the earliest stages of disease initiation and progression. This discovery is what has led me down the path to studying the role of the epigenome in human health and disease, including an industry-academia collaboration with Syros pharmaceuticals that resulted in what is now a Phase 3 clinical trial in MDS (NCT04797780).

— Ryan Corces, PhD

Location

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Li Ka Shing Center for Learning & Knowledge
LK130

291 Campus Dr
Stanford, CA 94305
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