March 22 Mar 22
2022
Tuesday Tue
PST: ZOOM

Pathology Grand Rounds

Presenting Guest Lecturer: Satish Pillai, PhD
"From HIV-1 to CoV-2: Lessons from the Host-Virus Interface"

Zoom meeting ID: https://stanford.zoom.us/j/99623837136?pwd=bm5GUzJCVitScmF2dGhtUW8vODZFdz09

Please note: This meeting requires a password, please contact Roomana Patel at roomana@stanford.edu or 650-725-9352 for more information.

The Pathology Grand Rounds is open to those affiliated with Stanford University Medical Center and invited guests only. The objective is to increase knowledge in the field of Pathology. There is no commercial support received for this course unless otherwise specified.

This lecture is hosted by Stanford Pathology Faculty

About the Speaker

Satish Pillai, PhD

Professor of Laboratory Medicine, UCSF

From HIV-1 to CoV-2: Lessons from the Host-Virus Interface

My laboratory uses a systems biology approach to decipher the antiretroviral effects of IFN-α in vivo, by studying host gene expression, viral production and viral evolution in HIV-1-infected individuals undergoing IFN-α therapy. Recent data generated by our group strongly suggest that IFN-α suppresses HIV-1 replication in chronically-infected individuals by inducing intrinsic cellular inhibitors of retroviral replication known as host restriction factors. One of these factors, the cytidine deaminase APOBEC3G, blocks HIV-1 infection by hyper-mutating the viral genome such that it no longer encodes functional proteins that are necessary for viral replication. Another factor, the type 2 integral membrane protein BST-2/tetherin, blocks HIV-1 infection by restricting the release of fully formed progeny virions from infected cells. Our data warrant investigation into therapeutic strategies that specifically enhance the expression of these intrinsic immune factors in HIV-1-infected individuals.

In addition to my principal research projects involving IFN-α and cell-intrinsic immunity, I participate as a bioinformaticist and phylogeneticist in a number of HIV/AIDS collaborations with researchers at the San Francisco VA Medical Center (SFVAMC), San Francisco General Hospital (SFGH) and the Gladstone Institute of Virology and Immunology (GIVI).