Product definition Neumeyer et al Nat comm 2024

2024

Yang Y, Seninge L, Wang Z, Oro A, Stuart JM, Ding H.(2024) The manatee variational autoencoder model for predicting gene expression alterations caused by transcription factor perturbations.  Sci Rep. 2024 May 23;14(1):11794. doi: 10.1038/s41598-024-62620-z.PMID: 38782963.  LINK

Jussila AR, Haensel D, Gaddam S, Oro, AE (2024). Acquistion of Drug Resistance in Basal Cell Nevus Syndrome Tumors through Basal-to-Squamous Cell Carcinoma Transition.  J Invest Dermatol 144(6):1368-1377 PMID:38157930 LINK

Mittal V, Nazaroff J, Eid E, Li S, Linos E, Oro A, Tang JY. (2024) Online, home-based, dystrophic epidermolysis bullosa registry. Pediatr Dermatol. 2024 Sep-Oct;41(5):845-848. doi: 10.1111/pde.15682. Epub 2024 Jun 28.PMID: 38943317 LINK

Lukowiak TM, Cahn B, Samie F, Leffell DJ, Oro A, Kibbi N, Kheterpal M, Babakoohi S, Khushalani NI, Stephenson A, Ma MS, Shi VJ, Ahmed A, Koza E, Haq M, Yi MD, Nadir U, Yoo S, Brieva JC, Lucas J, Haber R, Alam M (2024) Developing expert consensus for theuse of hedgehog inhibitors in basal cell nevus syndrome.  Arch Dermatol Res. 2024 Jul 5;316(7):453. doi: 10.1007/s00403-024-03157-z.PMID: 38967654 LINK

Neumayer G, Torkelson JL, Li S, McCarthy K, Zhen HH, Vangipuram M, Mader MM, Gebeyehu G, Jaouni TM, Jacków-Malinowska J, Rami A, Hansen C, Guo Z, Gaddam S, Tate KM, Pappalardo A, Li L, Chow GM, Roy KR, Nguyen TM, Tanabe K, McGrath PS, Cramer A, Bruckner A, Bilousova G, Roop D, Tang JY, Christiano A, Steinmetz LM, Wernig M, Oro, AE (2024).  A scaleable and cGMP-compatible autologous organotypic cell therapy for Dystrophic Epidermolysis Bullosa. Nat Commun. 2024 Jul 11;15(1):5834. doi: 10.1038/s41467-024-49400-z.PMID: 38992003 LINK

Li NY, Zhang W, Haensel D, Jussila AR, Pan C, Gaddam S, Plevritis SK, Oro, AE (2024). Basal-to-Inflammatory transition and tumor resistance via cross-talk with a pro-inflammatory stromal niche Nat Commun. 2024 Sep 17;15(1):8134. doi: 10.1038/s41467-024-52394-3.PMID: 39289380. LINK

Zhang, Y, Karagiannis, D, Liu, H, Lin, M, Fang, Y, Jiang, M, Chen, X, Suresh, S, Huang, H, She, J, Shi, F, Yang, P, El-Rifai, W, Zaika, A, Oro, AE, Rustgi, K, Wang, TC, Lu, C, Que, J (2023) Epigenetic regulation of p63 blocks squamous-to-neuroendocrine transdifferentiation in esophageal development and malignancy. Sci Adv. 2024 Oct 11;10(41):eadq0479. doi: 10.1126/sciadv.adq0479. Epub 2024 Oct 9.PMID: 39383220. LINK

Thomas D, Noishiki, C, Gaddam, S, Wu, D, Manhas, A, Liu, Y, Tripathi, D, Kathale, N, Adkar, SS, Garhyan J, Liu, C, Xu, B, Ross, EG, Dalman, RL, Wang, KC, Oro, AE, Sallam, K, Lee JT, Wu, JC, Sayed, N. (2024) CCL2-mediated endothelial injury drives cardiac dysfunction in long COVID. Nat Cardiovasc Res 3(10): 1249-1265 PMID: 39402206  LINK

Yang Y, McCullough, CG, Seninge, L, Guo, L, Kwon, WJ, Zhang, Y, Li, NY, Gaddam, S, Pan, C, Zhen, H, Torkelson, J, Glass, IA, Birth Defects Research Lab, Charville, G, Que, J, Stuart, J, Ding, H, Oro, AE (2023) A Spatiotemporal and Machine-Learning Platform Accelerates the Manufacturing of hPSC-derived Esophageal Mucosa. Development Cell, in press bioRxiv [Preprint]. 2023 Oct 26:2023.10.24.563664. doi: 10.1101/2023.10.24.563664.PMID: 37961271. LINK

garphical abstract collier et al iScience

2023

Collier AE, Piekos SN, Liu A, Pattison JM, Felix F, Bailetti AA, Sedov E, Gaddam S, Zhen H, Oro AE. (2023).   GRHL2 and AP2 coordinate early surface ectoderm lineage commitment during development.  iScience. 2023 Feb 3;26(3):106125. doi: 10.1016/j.isci.2023.106125. PMID: 36843855.  LINK

Haensel D, Daniel B, Gaddam S, Pan C, Fabo T, Bjelajac J, Jussila AR, Gonzalez F, Li NY, Chen Y, Hou J, Patel T, Aasi S, Satpathy AT, Oro AE. (2023) Skin basal cell carcinomas assemble a pro-tumorigenic spatially organized and self-propagating Trem2+-myeloid niche. Nat Commun. 2023 May 10;14(1):2685. doi: 10.1038/s41467-023-37993-w.PMID: 37164949. LINK

Ober-Reynolds B, Wang C, Ko JM, Rios EJ, Aasi SZ, Davis MM, Oro AE, Greenleaf WJ. (2023) Integrated single-cell chromatin and transcriptomic analysis of human scalp identify gene-regulatory programs and critical cell types for hair and skin diseases. Nat Genet. 2023 Aug;55(8):1288-1300. doi: 10.1038/s41588-023-01445-4. Epub 2023 Jul 27.PMID: 37500727. LINK

Model for Gibbin action during surface ectoderm development and in Xia-Gibbs Syndrome

2022

Matheus, F, Raveh, T, Oro AE, Wernig, M, Drukker, M. (2022)  Is hypoimmunogenic stem cell therapy safe in times of pandemics? Stem Cell Reports 17(4):711-714. PMID: 35334219. LINK

Collier, A, Liu, A, Torkelson, J, Pattison, J, Gaddam, S, Zhen, H, Patel, T, McCarthy, K, Ghanim, H, and Oro AE (2022) Gibbin (AHDC1) mesodermal regulation patterns epithelial development.  Nature 606 (79212) 188-196. PMID: 35585237.  LINK

Shue, YT, Drainas, AP, Li, NY, Pearsall, SM, Morgan, D, Sinnott-Armstrong, N, Hipkins, SQ, Coles, GL, Lim, JS, Oro, AE, Simpson, KL Dive, C, Sage, J (2022) A conserved YAP/Notch/REST network controls the neuroendocrine cell fate in the lungs. Nat Commun 13(1): 2690 PMID: 35577801.  LINK

Bartl J, Zanini M, Bernardi F, Forget A, Blümel L, Talbot J, Picard D, Qin N, Cancila G, Gao Q, Nath S, Koumba IM, Wolter M, Kuonen F, Langini M, Beez T, Munoz C, Pauck D, Marquardt V, Yu H, Souphron J, Korsch M, Mölders C, Berger D, Göbbels S, Meyer FD, Scheffler B, Rotblat B, Diederichs S, Ramaswamy V, Suzuki H, Oro AE, Stühler K, Stefanski A, Fischer U, Leprivier G, Willbold D, Steger G, Buell A, Kool M, Lichter P, Pfister SM, Northcott PA, Taylor MD, Borkhardt A, Reifenberger G, Ayrault O, Remke M.(2022) The HHIP-AS1 lncRNA promotes tumorigenicity through stabilization of dynein complex 1 in human SHH-driven tumors. Nat Commun 13 (1): 4061 PMID: 35831316.   LINK

Haensel D, Gaddam S, Li NY, Gonzalez F, Patel T, Cloutier JM, Sarin KY, Tang JY, Rieger KE, Aasi SZ, Oro AE (2022) LY6D marks pre-existing resistant basosquamous tumor subpopulations. Nat Commun 13 (1): 7520. PMID: 36473848. PMID: 36473848. LINK

 

fig 3 mirza et al COCB 2020

2021

Kuonen, F, Li, NY, Haensel, D, Patel, T, Gaddam, S, Yerly, L, Rieger, K, Aasi, S, and Oro AE (2021) C-FOS drives reversible basal to squamous cell carcinoma transition Cell Reports 37(1):109774   PMID:34610301. LINK

Kilgour, JM, Shah, A, Urman, NM, Eichstadt, S, Do HN, Bailey I, Mirza A, Li, S, Oro, AE, Aasi, S, and Sarin, KY (2021) Phase II Open-Label, Single Arm Trial to Investigate the Efficacy and Safety of Topical Remetinostat Gel in Patients with Basal Cell Carcinoma, Clinical Cancer Research 27(17) 4717-4725 PMID: 34362809. LINK

Piekos, SN, Gaddam, S, Bhardwaj, P, Radhakrishnan, P, Guha, RV, and Oro AE (2021) Biomedical Data Commons (BMDC) prioritizes B-lymphocyte non-coding genetic variants in Type 1 Diabetes. PLOS Computational Biology 17(9): e1009382 PMID:34543288. LINK

Mirza, AN, Gonzalez, F, Ha, SK and Oro, AE (2021) The Sky’s the LEMit: New insights into nuclear structure regulation of transcription factor activity. Curr Op Cell Biol 68:173-180. LINK

Kuonen et al cell reports 2021

2020

Yao, CY, Haensel, D, Gaddam, S, Patel, T, Atwood, SX, Sarin KY, Whitson RJ, McKellar S, Shankar, G, Aasi, S, Rieger, K, and Oro, AE (2020) AP-1 and TGFß cooperativity drives non-canonical Hedgehog signaling in resistant basal cell carcinoma Nature Communications 11(1):5079.  LINK

Haensel, D and Oro, AE (2020) Starve a cold, and perhaps a cancer Nature Cell Biol 22(7) 755-757. LINK

Brown, AS, Meera, P., Quinones, G., Magri, J., Otis, TS, Pulst, M., and Oro AE (2020) Receptor Protein Tyrosine Phosphatases Control Purkinje Neuron Firing Cell Cycle19(2):153-159.  LINK

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graphical abstract from mirza et al.

2019

Li, L, Wang, Y, Torkelson, JL, Pattison, JM, Zhen, HH, Duren, Z, Fang, F, Melo, SP, Piekos SN, Li, J, Liaw, EJ, Chen, L., Li, R., Wernig, M, Wong, WH,  Chang, HY, and Oro, AE (2019) Feedback Regulation between Initiation and Maturation Networks Orchestrates the Chromatin Dynamics of Epidermal Lineage Commitment, Cell Stem Cell 24 (2), 271-284.e8.  LINK

Mirza, AN, McKellar, SA, Urman, NM, Brown, AS, Hollmig, T., Aasi, SZ, and Oro AE (2019) LAP2 proteins Chaparone Gli1 movement between Lamina and Chromatin to regulate Transcription, Cell 176 (1-2), 198-212.e15.  LINK

Kuonen, F., Huskey, N, Shankar, G., Jaju, P, Whitson, RJ, Rieger, KE, Atwood, SX, Sarin, KY, and Oro AE (2019) Loss of Primary Cilia Drives Switching from Hedgehog to RAS/MAPK pathway in resistant basal cell carcinoma J Invest Dermatol 139 (7) 1439-1448.  LINK

Chiang, A, Tan, CZ, Kuonen F., Hodgkinson, LM, Chiang, F, Cho, RJ, South, AP, Tang, JY, Chang, ALS, Rieger, KE, Oro, AE, Sarin KY (2019) Genetic Mutations underlying phenotypic plasticity in basosquamous carcinoma J Invest Dermatol 139 (11) 2263-2271  LINK

Sohn, GK, Kwon, GP, Bailey-Healy, I, Mirza, A, Sarin, KY, Oro A, Tang, JY (2019) Topical Itraconazole for the treatment of basal cell carcinoma in patients with basal cell nevus syndrome or high frequency basal cell carcinomas: A phase 2, open-label, placebo-controlled trial JAMA Dermatol 155 (9), 1078-1080. LINK

whitson nat med model

2018

Whitson RJ, Lee A, Urman NM, Mirza A, Yao CY, Brown AS, Li JR, Shankar G, Fry MA, Atwood SX, Lee EY, Hollmig ST, Aasi SZ, Sarin KY, Scott MP, Epstein EH Jr, Tang JY, Oro AE.(2018) Noncanonical hedgehog pathway activation through SRF-MKL1 promotes drug resistance in basal cell carcinomas. Nature Medicine. 2018 Mar;24(3):271-281.  LINK

Kuonen F, Surbeck I, Sarin KY, Dontenwill M, Rüegg C, Gilliet M, Oro AE, Gaide O (2018) TGFB, Fibronectin, and Integrin a5B1 Promote Invasion in Basal cell carcinoma J Invest Dermatol. Jul 14. pii: S0022-202X(18)31966-3. LINK

Cho HG, Kuo KY, Li S, Bailey I, Aasi S, Chang ALS, Oro AE, Tang JY, Sarin KY (2018) Frequent basal cell cancer development is a clinical marker for inherited cancer susceptibility JCI Insight. 2018 Aug 9;3(15). pii: 122744. doi: 10.1172/jci.insight.122744. See commentaries in Stanford Medicine and national news. LINK

Drummond ML, Li M, Tarapore E, Nguyen TTL, Barouni BJ, Cruz S, Tan KC, Oro AE, Atwood SX (2018) Actin Polymerization controls cilia-mediated signaling J Cell Biol. Sep 3;217(9):3255-3266. LINK

Pattison, JM, Melo, SP, Piekos SN, Torkelson JL, Bashkirova, E, Mumbach, MR, Rajasingh, C. Zhen, HH, Li, L, Liaw, EJ, Alber, D, Rubin, AJ, Shankar, G, Bao, X, Chang, HY, Khavari, PA, and Oro, AE (2018) Retinoic Acid and BMP4 Cooperate with TP63 to alter chromatin dynamics during Surface Epithelial Commitment Nature Genetics 50(12):1658-1665.   LINK

Brown, AS, Meera, P, Altindag, B, Chopra, R, Perkins, EM, Paul, S, Scoles, DR, Tarapore, E, Magri, J, Huang, H, Jackson, M, Shakkotai, VG, Otis, TS, Pulst, SM, Atwood, SX, and Oro, AE (2018) MTSS1/Src family kinase dysregulation underlies multiple inherited ataxias.  Proc Natl Acad Sci Dec 7 115 (52) E12407-12416. LINK

li et al cell stem cell 2019

2017

Whitson RJ, Oro AE (2017) Soil Primes the Seed: Epigenetic Landscape Drives Tumor Behavior Cell Stem Cell. Feb 2;20(2):149-150. LINK

Mirza AN, Fry MA, Urman NM, Atwood SX, Roffey J, Ott GR, Chen B, Lee A, Brown AS, Aasi SZ, Hollmig T, Ator MA, Dorsey BD, Ruggeri BR, Zificsak CA, Sirota M, Tang JY, Butte A, Epstein E, Sarin KY, Oro AE (2017) Combined inhibition of atypical PKC and histone deacetylase 1 is cooperative in basal cell carcinoma treatment. JCI Insight. 2017 Nov 2;2(21). pii: 97071. doi: 10.1172/jci.insight.97071. LINK

New aPKC inhibitor

2016

Danial C, Sarin KY, Oro AE, Chang AL (2016) An Investigator-Initiated Open-Label Trial of Sonidegib in Advanced Basal Cell Carcinoma Patients Resistant to Vismodegib. Clin Cancer Res. Mar 15;22(6):1325-9. LINK

Kwon GP, Ally MS, Bailey-Healy I, Oro AE, Kim J, Chang AL, Aasi S, Tang JY (2016)  Update to an open-label clinical trial of vismodegib as neoadjuvant before surgery for high-risk basal cell carcinoma  J Am Acad Dermatol. Jul;75(1):213-5. LINK

Wang K, Lee CS, Marinkovich MP, Chang HY, Oro AE, Khavari PA (2016) Factors that may promote an effective local research environment J Invest Dermatol.Aug;136(8):1529-31. LINK

Smith AA, Li J, Liu B, Hunter D, Pyles M, Gillette M, Dhamdhere GR, Abo A, Oro A, Helms JA (2016) Activating Hair Follicle Stem Cells via R-Spondin2 to Stimulate Hair Growth. J Invest Dermatol. 2016 Aug;136(8):1549-1558. doi: 10.1016/j.jid.2016.01.041. Epub 2016 Apr 22.PMID: 27109869. LINK

Ally MS, Ransohoff K, Sarin K, Atwood SX, Rezaee M, Bailey-Healy I, Kim J, Beachy PA, Chang AL, Oro A, Tang JY, Colevas AD. (2016) Effects of Combined Treatment with Arsenic Trioxide and Itraconazole in Patients with Refractory Metastatic Basal Cell Carcinoma JAMA Dermatol. 2016 Apr;152(4):452-6. doi: 10.1001/jamadermatol.2015.5473.PMID: 26765315 LINK

Kennedy Crispin M, Ko JM, Craiglow BG, Li S, Shankar G, Urban JR, Chen JC, Cerise JE, Jabbari A, Winge MC, Marinkovich MP, Christiano AM, Oro AE, King BA (2016) Safety and efficacy of the JAK inhibitor tofacitinib citrate in patients with alopecia areata. JCI Insight. Sep 22;1(15):e89776  LINK

Urman NM, Mirza A, Atwood SX, Whitson RJ, Sarin KY, Tang JY, Oro AE (2016) Tumor-Derived Suppressor of Fused Mutations Reveal Hedgehog Pathway Interactions PLoS One. Dec 28;11(12):e0168031. LINK

Cell

2015

Atwood, SX, Sarin, KY, Whitson,RJ, Li, JR, Kim, G, Rezaee, M., Ally, MS, Kim, J, Yao, CY, Chang, ALS*, Oro, AE*, and Tang, JY* (2015) Smoothened Variants Explain the Majority of Drug Resistance in Basal Cell Carcinoma. Cancer Cell 27:342-353  * co-senior authors. See also accompanying Preview by Ridky and Cotsarelis. LINK

Atwood, SX, Sarin KY, Li, JR, Yao, CY, Urman, NM, Chang, ALS, Tang, JY, and Oro AE (2015) Rolling the Genetic Dice: Neutral and Deleterious Smoothened Mutations in Drug Resistant Basal Cell Carcinomas, J Invest Dermatol  doi:10.1038/jid.2015.115. LINK

Zhao X, Ponomaryov T, Ornell KJ, Zhou P, Dabral SK, Pak E, Li W, Atwood SX, Whitson RJ, Chang AL, Li J, Oro AE, Chan JA, Kelleher JF, Segal RA (2015)  RAS/MAPK Activation Drives Resistance to SMO Inhibition Metastasis and Tumor Evolution in Shh-Dependent Tumors Cancer Res. Sep 1;75(17):3623-35 LINK

Jaju PD, Nguyen CB, Mah AM, Atwood SX, Li J, Zia A, Chang ALS, Oro AE, Tang JY, Lee CS, Sarin KY (2015) Mutations in the Kinetochore Gene KNSTRN in Basal Cell Carcinoma. J Invest Dermatol. Dec;135(12):3197-3200. LINK

stm 2014

2014

Melo, S. Lisowski, L. Bashkirova, E. Zhen H. Chu K. Keene, D. Marinkovich, P. Kay, M. Oro, AE (2014) Somatic scarless correction of junctional epidermolysis bullosa by a highly recombinogenic AAV virus. Mol Therapy 22:725-33 LINK

Atwood, SX and Oro, AE (2014) “Atypical” Regulation of Hedgehog-dependent cancers Cancer Cell 25:133-4. LINK

Tang, Y. Schubert, S. Bandopadhaay, P. Bergthold, G. Nguyen, B. Masoud, S. Vue, N. Balansay B. , Yu, F., Oh, S., Chen, S. Ponnuswami, A. Monje-Diesseroth, M., Atwood, SX, Whitson RJ, Lee, A, Tang, JY, Qi, J, Beroukhim, R., Wechsler-Reya, R., Oro, AE, Bradner, JE, and Cho, YJ,  (2014)  Epigenetic Regulation of Hedgehog Pathway transcriptional output by BRD4  Nature Med 20:732-40.  LINK

Oro, AE and Watt, FM. (2014), editors. The Skin and Its Diseases.  Cold Spring Harbor Perspectives in Medicine CSH Press: New York. 

Atwood, SX, Whitson, R., and Oro AE (2014) Advanced Basal Cell Carcinoma Therapy, in Cold Spring Harbor Perspectives in Medicine Oro AE and Watt, FM, eds.  CSH Press: New York. LINK

Sebastiano, V, Zhen HH, Derafshi, BH, Bashkirova, L, Melo, S, Wang, P, Leung, T, Siprashvili, Tichy, A., Li,J, Ameen M., Hawkins, J., Lee, S., Li, L, Bauer, G., Lisowski, Kay, M., Kim, SK, Lane, AT, Wernig, M. and Oro, AE (2014) Corrected Induced Pleuripotent Stem Cell Based Therapy for the Treatment of Recessive Dystrophic Epidermolysis Bullosa, Sci Transl Med 6:264-7.  LINK

stm 2014

2013

Atwood, SX., Tang, J, Chang, A., Li, M., and Oro, AE (2013), “Gli activation by aPKC regulates BCC growth” Nature 2013 494:484-8.  LINK

Aasi, S. Silkiss, R., Tang, JY, Wysong, A. Liu, A. Epstein, E. Oro, AE, Chang AL (2013) New onset keratoacanthomas after vismodegib treatment fro locally advanced basal cell carcinoma: a report of 2 cases. JAMA Dermatol 149:242-3. LINK

Woo WM, Atwood SX, Zhen HH, Oro AE (2013) Rapid Genetic Analysis of epithelial-mesenchymal signaling during hair regeneration. J Vis Exp Feb 28: (72) e4344.  LINK

Danial C, Lingala B, Balise R, Oro AE, Reddy S, Colevas A, Chang AL (2013) Markedly improved overall survival in 10 consecutive metastatic basal cell carcinoma patients.  Br J Dermatol, March 23, epub.  LINK

Xiao Y, Woo WM, Nagao K, Li W, Terunuma A, Mukouyama YS, Oro AE, Vogel JC, Brownell I. (2013) Perivascular hair follicle stem cells associate with a venule annulus J Invest Dermatol  133:2324-31. LINK

Atwood, SX, Whitson RJ, Oro, AE (2013) “Patch”ing up our tumor signaling knowledge J Invest Derm 133:1131-3. LINK

Chang AL, Atwood SX, Tartar DM, Oro AE (2013)  Surgical excision after neoadjuvant therapy with vismodegib for a locally advanced basal cell carcinoma and resistant basal cell carcinoma in Gorlin Syndrome JAMA Dermatol 149:639-41.  LINK

Yucel, G, Altindag, B. Gomez-ospina, N. Rana, A. Panagiotakos, G., Lara, MF, Dolmetsch, R and Oro, AE (2013) State-dependent signaling by Cav1.2 regulates hair follicle stem cell function, Genes Dev. 27: 1217-22. LINK

Whyte, JL, Smith AA, Liu B., Manzano WR, Evans, ND, Dhamdhere GR, Fang, MY, Chang, HY, Oro, AE, and Helms, JA (2013)  Augmenting endogenous Wnt signaling improves skin wound healing PLoS One 8:e76883. LINK

Yucel, G. Arnam, J. Case-Means P. Huntzicker, E. Lara, M. Yuan J. Kuo C. and Oro, AE  (2014) Partial Proteasome Inhibitors Induce Hair Follicle Growth by Stabilizing B-catenin, Stem Cells 32:85-92   LINK

stm 2014

2012

Gomez-Ospina N, Chang A, Qu K, Oro AE. (2012) A Sonic Hedgehog Locus Translocation associated with Basal Cell Carcinomas. N Engl J Med 366, 2233-4. LINK

Sekulic A, Migden, MR, Oro, AE, Dirix L, Lewis KD, Hainsworth JD, Solomon JA, Yoo S, Arron ST, Friedlander PA, Marmur E, Rudin CM, Chang ALS, Low JA, Mackey HM, Yauch RL, Graham RA, Reddy JC, Hauschild A. (2012)  Efficacy and Safety of Vismodegib in Advanced Basal Cell Carcinoma. N Engl J Med 366:2171-9. LINK

Woo W-M, Zhen HH, Oro AE. (2012) Shh maintains dermal papilla identity and hair morphogenesis via a Noggin – Shh regulator loop. Genes and Dev 26: 1235-46. LINK

Atwood, SX, Chang, ALS, and Oro, AE (2012) Hedgehog pathway inhibition and the race against tumor evolution J Cell Biol 199:193-7. LINK

Chang, ALS and Oro, AE (2012) Initial Assessment of tumor regrowth after vismodegib in advanced Basal cell carcinoma Arch Dermatol 148:1324-5. LINK

Oro, AE and Tang, JY (2012). Basal Cell Nevus Syndrome. In:  Fitzpatrick’s Dermatology in General Medicine, 8th Edition. The McGraw-Hill Companies, Inc. Publisher.

stm 2014

2011

Ra H, Piyawattanametha W, González-Gonzalez E, Mandella MJ, Kino GS, Solgaard O, Leake D, Kaspar R, Oro AE, Contag CH. (2011). In vivo imaging of human and mouse skin with a handheld dual-axis confocal fluorescence microscope, J Invest Dermatol. 13, 1061-6.  LINK

Yucel G, and Oro, AE. (2011). Cell Migration:GSK3ß steers the cytoskeleton’s tip, Cell  144, 319-21.  LINK

Woo WM, Oro AE. (2011). SnapShot: hair follicle stem cells. Cell. 146, 334-334.e2.  LINK

Bree AF, Shah MR; BCNS Colloquium Group. (2011) Consensus statement from the first international colloquium on basal cell nevus syndrome (BCNS) Am J Med Genet A. 2011 Sep;155A(9):2091-7. doi: 10.1002/ajmg.a.34128. Epub 2011 Aug 10.PMID: 21834049 LINK

Hillman RT, Feng BY, Ni J, Woo W-M, Milenkovic L, Hayden Gephart MG, Teruel MN, Oro AE, Chen JK, Scott MP. (2011). Neuropilins are positive regulators of Hedgehog signal transduction. Genes Dev. 25, 2333-46.  LINK

stm 2014

2010

Quinones GA, Jin J, Oro AE. (2010). I-BAR protein antagonism of endocytosis mediates directional sensing during guided cell migration. J Cell Biol. 189, 353-67.  LINK

Quinones GA, Oro AE. (2010). BAR domain competition during directional cellular migration. Cell Cycle. 9,  Epub Jul 19;9(13).  LINK

Bershteyn M, Atwood SX, Woo W-M, Li M, Oro AE. (2010). MIM and cortactin antagonism regulates ciliogenesis and Hedgehog signaling. Dev Cell. 19, 270-283.  LINK

DeRouen MC, Zhen H, Tan SH, Williams S, Marinkovich MP, Oro AE. (2010).  Laminin-511 and integrin beta-1 in hair follicle development and basal cell carcinoma formation. BMC Dev Biol. 10:112-5.   LINK

stm 2014

2005-2009

Gonzalez-Quevedo, R., Shoffer, M., Horng, L., and Oro A. E., (2005). Receptor tyrosine phosphatase-dependent Cytoskeletal remodeling by the hedgehog-responsive gene MIM / BEG4 J Cell Biol 168, 453-463. LINK

Sarin, KY, Cheung, P, Gillison, D, Lee, E, Tennen, RI, Wang, E, Artandi, MK, Oro AE, and Artandi, SE (2005). Conditional telomerase induction causes proliferation of hair follicle stem cells.  Nature 436, 1048-52. LINK

Huntzicker E.G., Estay I, Zhen H., Lokteva L.A., Jackson P. K., Oro A.E., (2005). Dual degradation signals control Gli stability and tumor formation Genes Dev 20, 276-81.  LINK

Oro, A.E. (2005). Spatial and temporal regulation of hair follicle progenitors by hedgehog signaling. In:  Hedgehog-Gli Signaling and Human Disease. Ariel Ruiz I Altaba, editor. Kluwer Academic / Plenum Publishers, Landes Bioscience.

Oro AE (2006). Mammalian Variations on a Theme: a Smo and Sufu Surprise: Dev Cell 10:156. LINK

Sneddon, J.B., Zhen, H.H., Montgomery, K., van de Rijn, M., Tward, A.D., West, R., Gladstone, H., Chang, H., Morganroth, G.S., Oro, AE., Brown. P.O. (2006).  BMP Antagonist Gremlin 1 is Widely Expressed by Cancer-associated Stromal Cells and Can Promote Tumor Cell Proliferation. Proc Natl Acad Sci 103, 14842-7.  LINK

Oro AE., (2007). The Primary cilia, a ‘Rab-id’ transit system for hedgehog signaling. Current Opinion in Cell Biology 19, 1-6.  LINK

Huntzicker E.G., Oro, AE., (2008).  Controlling Hair Follicle Signaling Pathways through Polyubiquitination.  J Invest Dermatol. 128, 1081-7. LINK

Oro, AE (2008) Dermatology in the postgenomic era: harnessing human variation for personalized medicine. Arch Dermatol. 2008 Mar;144(3):389-91. doi: 10.1001/archderm.144.3.389.PMID: 18347297. LINK

Oro, AE. (2008).  A new role for an old friend: NFAT and stem cell quiescence. Cell Stem Cell 2, 104-6. LINK

Gao, J, DeRouen, M., Chen, C-H., Nguyen, M, Nguyen, N.T., Ido, H., Harada, K., Sekiguchi, K., Morgan, B.A., Miner, J., Oro, A.E. and Marinkovich, M.P. (2008).  Laminin-511 is an epithelial message promoting dermal papilla development and function during early hair morphogenesis. Genes Dev 22, 2111-24. LINK

Oro, AE. (2008). Basal Cell Nevus Syndrome. In:  Fitzpatrick’s Dermatology in General Medicine, 7th Edition. The McGraw-Hill Companies, Inc. Publisher.

DeRouen MC, Oro AE. (2009). The primary cilium: a small yet mighty organelle. J Invest Dermatol. 129, 264-5. Review. LI

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2000-2004

Callahan, C.A. and Oro, A.E., (2001). Monstrous attempts at adnexogenesis: regulating hair follicle progenitors through Sonic hedgehog signaling.  Curr Opin Genet Dev, 11:541-6.  LINK

Oro, A.E., Higgins, K, (2003). Hair cycle regulation of Hedgehog signal reception, Dev Bio 253, 23-44.  LINK

Chang, HY, Ridky, TW, Kimball, AB, Hughes, E, and Oro AE, (2003). Eruptive xanthomas associated with olanzapine use, Arch Dermatol, Aug;139(8):1045-8.  LINK

Gotlib J, Kohler S, Reicherter P, Oro AE, Zehnder JL. (2003). Heterozygous prothrombin G20210A gene mutation in a patient with livedoid vasculitis. Arch Dermatol, 139, 1081-3.  LINK

Callahan, C.A., Ofstad, T., Horng  L., Wang J.K., Zhen H.H., Coulombe P.A., and Oro A.E. (2004). BEG4 / MTSS1, a Sonic hedgehog target gene that potentiates Gli transcription Genes Dev.18, 2724-9.  LINK

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1996-1999

Oro, A.E., Higgins, K.M., Hu, Z., Bonifas, J.M., Epstein, E.H., and Scott, M.P. (1997). Basal Cell Carcinomas in Mice Overexpressing Sonic Hedgehog.  Science 276, 817-821.  LINK

Fan, H., Oro, A.E., Scott, M.P., and Khavari, P. A., (1997). Induction of basal cell carcinoma features in transgenic human skin expressing Sonic Hedgehog.  Nature Med 3, 788-792.  LINK

Oro, A.E. and Scott, M.P. (1998). Splitting Hairs: Dissecting Roles of Signaling Systems in Epidermal Development, Cell 95, 575-578. LINK

Azsterbaum, M, Epstein, J., Oro, A., Douglas, V., LeBoit, P.E., Scott, M.P., and Epstein, E.H. (1999). Ultraviolet and ionizing radiation enhance the growth of BCCs and trichoblastomas in patched heterozygous knockout mice,  Nature Med 5, 1285-1291.  LINK

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1990-1995

Oro, A.E., McKeown, M., and Evans, R.M.(1990).  Relationship between the product of the Drosophila ultraspiracle locus and the vertebrate retinoic acid responsive transcription factor, the Retinoid X receptor.  Nature 347, 298-301.  LINK

Mangelsdorf, D.J., Borgmeyer, U., Heyman, R.A., Zhou, J., Ong, E.S., Oro, A.E., Kakizuka, A., and Evans, R.M. (1992). Characterization of the three RXR genes that mediate the action of 9-cis retinoic acid. Genes Dev 6,  329-344. LINK

Oro, A.E., McKeown, M. and Evans, R.M. (1992). The Drosophila Retinoid X receptor homolog ultraspiracle functions in both female reproduction and eye morphogenesis. Development 115, 449-462. LINK

Yao, Tso-Pang, Segraves, W.A., Oro, A.E., McKeown, M., and Evans, R.M.(1992). Transactivation by the ecdysone receptor requires the conserved heterodimerization function of ultraspiracle. Cell 71,  63-72.  LINK

Oro, A.E., McKeown, M., and Evans, R.M. (1992). The Drosophila nuclear receptors: new insight into the actions of nuclear receptors in development.  Curr Op Genet Dev 2, 269-274. LINK

Forman BM, Goode E, Chen J, Oro AE, Bradley DJ, Perlmann T, Noonan DJ, Burka LT, McMorris T, Lamph WW, Evans RM, Weinberger C. (1995) Identification of a nuclear receptor that is activated by farnesol metabolites. Cell. 1995 Jun 2;81(5):687-93. doi: 10.1016/0092-8674(95)90530-8.PMID: 7774010 LINK

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1984-1989

Oro, A.E. and Walbot, V. (1984). Speculations about Lack of Variation in B37N Mitochondrial DNA.  Maize Cooperative Newsletter 58, 187.

Oro, A.E., Newton, K.J., and Walbot, V. (1984). Lack of Variation in B37N Mitochondrial DNA in Maize.  Maize Cooperative Newsletter 58, 186.

Oro, A.E., Newton, K.J., and Walbot, V. (1985).  Molecular Analysis of the Inheritance and Stability of the Mitochondrial Genome of an Inbred Line of Maize. Theoretical and Applied Genetics 70, 287-293. 

Hollenberg, S.M., Weinberger, C., Ong, E.S., Cerelli, G., Oro, A., Lebo, R., Thompson, E.B., Rosenfeld, M.G., and Evans R.M.(1985).  Primary Structure and Expression of a Functional Human Glucocorticoid Receptor cDNA. Nature 318, 635-641.  LINK

Oro, A.E., Simerly, R.B., and Swanson, L.W.(1988). Estrous Cycle Variations in Levels of CCK Immunoreactivity within cells of Three Interconnected Sexually Dimorphic Forebrain Nuclei.  Neuroendocrinology 47, 225-235.

Oro, A.E., Hollenberg, S.M., and Evans R.M.(1988).  Transcriptional Inhibition by a Glucocorticoid receptor-ß-galactosidase Fusion protein. Cell 55, 1109-1114. LINK

Oro, A.E., Ong, E.S., Margolis, J.S., Posakony, J.W., McKeown, M., and Evans, R.M.(1988). The Drosophila gene knirps-related is a member of the steroid receptor gene superfamily.  Nature 336, 493-496.  LINK

Hong, F.D., Huang, H.J., To, H., Young, L.J., Oro, A.,  Bookstein, R., Lee, E.Y., and Lee, W.H.(1989).  Structure of the Human Retinoblastoma Gene.  Proc Natl Acad Sci USA 86, 5502-5506.

Oro, A.E., Umesono, K., and Evans R.M. (1989). Steroid Hormone Receptor Homologs in Development. Development 107 (Suppl.), 133-140.