Hidden hearing loss: cellular/molecular mechanisms; implications for auditory processing, and potential therapies

Mammalian hearing relies on the mechanical sound amplification provided by outer hair cells (OHCs), which enhance sensitivity and improve frequency selectivity. Unfortunately, OHCs are among the most vulnerable components in the cochlea and can be easily damaged by various stressors. To investigate the relationship between OHC function and vulnerability, we focus on several proteins essential for their function. These include Prestin, the motor protein responsible for OHC electromotility, and Oncomodulin, a cytosolic calcium-binding protein critical for the survival of OHCs. The knockout of these proteins in OHCs results in OHC loss. In this presentation, I will discuss our findings related to these OHC proteins and identify potential biomarkers for cochlear stress.