January 27 Jan 27
2023
Friday Fri

Meeting Details:

2:00PM-2:30PM - Refreshments
2:30PM-3:30PM – Seminar
Tung Auditorium, Biomedical Innovations Bldg – Room 1021

Host: Dr. Nicolas Grillet

Molecular Force-Sensors Essential for Hearing and Auditory Circuit Development

Ulrich Mueller, PhD, Johns Hopkins

Organisms of all phyla express mechanosensitive ion channels with a wide range of physiological functions. In recent years, several classes of mechanically gated ion channels have been identified. Some of these ion channels are intrinsically mechanosensitive. Others depend on accessory proteins to regulate their response to mechanical force. The mechanotransduction machinery of cochlear hair cells provides a particularly striking example of a complex force-sensing machine. This molecular ensemble is embedded into a specialized cellular compartment that is crucial for its function. Notably, mechanotransduction channels of cochlear hair cells are not only critical for auditory perception. They also shape their cellular environment and regulate the development of auditory circuitry. Here we summarize recent discoveries that have shed light on the composition of the mechanotransduction machinery of cochlear hair cells and how this machinery contributes to the development and function of the auditory system.

Speaker

Ulrich Mueller, PhD, Professor of Neuroscience and Biology
Solomon H. Snyder Department of Neuroscience
Johns Hopkins University

Location

Stanford University School of Medicine
240 Pasteur Dr. Rm 1021
Palo Alto, CA 94304
USA

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Stanford University School of Medicine

240 Pasteur Dr. Rm 1021
Palo Alto, CA 94304
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