Publications

   

Sensorineural Hearing and Hearing Loss

Kao, Shyan-Yuan, Sachiyo Katsumi, Dongjun Han, Argyro J. Bizaki-Vallaskangas, Sasa Vasilijic, Lukas D. Landegger, Arthur G. Kristiansen, Michael J. McKenna, and Konstantina M. Stankovic. “Postnatal Expression and Possible Function of RANK and RANKL in the Murine Inner Ear.” Bone 145 (April 2021): 115837. https://doi.org/10.1016/j.bone.2020.115837.

Stojkovic, Miodrag, Dongjun Han, Minjin Jeong, Petra Stojkovic, and Konstantina M. Stankovic. “Human Induced Pluripotent Stem Cells and CRISPR/Cas-Mediated Targeted Genome Editing: Platforms to Tackle Sensorineural Hearing Loss.” Stem Cells (Dayton, Ohio), February 14, 2021. https://doi.org/10.1002/stem.3353.

Stojkovic, Miodrag, Petra Stojkovic, and Konstantina M. Stankovic. “Human Pluripotent Stem Cells - Unique Tools to Decipher the Effects of Environmental and Intracellular Plastic Pollution on Human Health.” Environmental Pollution (Barking, Essex: 1987) 269 (January 15, 2021): 116144. https://doi.org/10.1016/j.envpol.2020.116144.

Lin, Brian M., Molin Wang, Konstantina M. Stankovic, Roland Eavey, Michael J. McKenna, Gary C. Curhan, and Sharon G. Curhan. “Cigarette Smoking, Smoking Cessation, and Risk of Hearing Loss in Women.” The American Journal of Medicine 133, no. 10 (October 2020): 1180–86. https://doi.org/10.1016/j.amjmed.2020.03.049.

Seist, Richard, Mingjie Tong, Lukas D. Landegger, Sasa Vasilijic, Hiroshi Hyakusoku, Sachiyo Katsumi, Charles E. McKenna, Albert S. B. Edge, and Konstantina M. Stankovic. “Regeneration of Cochlear Synapses by Systemic Administration of a Bisphosphonate.” Frontiers in Molecular Neuroscience 13 (July 14, 2020): 87. https://doi.org/10.3389/fnmol.2020.00087.

Katsumi, Sachiyo, Mehmet I. Sahin, Rebecca M. Lewis, Janani S. Iyer, Lukas D. Landegger, and Konstantina M. Stankovic. “Intracochlear Perfusion of Tumor Necrosis Factor-Alpha Induces Sensorineural Hearing Loss and Synaptic Degeneration in Guinea Pigs.” Frontiers in Neurology 10 (February 10, 2020): 1353. https://doi.org/10.3389/fneur.2019.01353.

Wu, Chen-Chi, Aurore Brugeaud, Richard Seist, Hsiao-Chun Lin, Wei-Hsi Yeh, Marco Petrillo, Giovanni Coppola, Albert S. B. Edge, and Konstantina M. Stankovic. “Altered Expression of Genes Regulating Inflammation and Synaptogenesis during Regrowth of Afferent Neurons to Cochlear Hair Cells.” PloS One 15, no. 10 (2020): e0238578. https://doi.org/10.1371/journal.pone.0238578.

Landegger, Lukas D., Sasa Vasilijic, Takeshi Fujita, Vitor Y. Soares, Richard Seist, Lei Xu, and Konstantina M. Stankovic. “Cytokine Levels in Inner Ear Fluid of Young and Aged Mice as Molecular Biomarkers of Noise-Induced Hearing Loss.” Frontiers in Neurology 10 (2019): 977. https://doi.org/10.3389/fneur.2019.00977.

Lin, Hsiao-Chun, Yin Ren, Andrew C. Lysaght, Shyan-Yuan Kao, and Konstantina M. Stankovic. “Proteome of Normal Human Perilymph and Perilymph from People with Disabling Vertigo.” PloS One 14, no. 6 (2019): e0218292. https://doi.org/10.1371/journal.pone.0218292.

Ren, Yin, Lukas D. Landegger, and Konstantina M. Stankovic. “Gene Therapy for Human Sensorineural Hearing Loss.” Frontiers in Cellular Neuroscience 13 (2019): 323. https://doi.org/10.3389/fncel.2019.00323.

Duarte, Maria J., Vivek V. Kanumuri, Lukas D. Landegger, Osama Tarabichi, Sumi Sinha, Xiankai Meng, Ariel Edward Hight, et al. “Ancestral Adeno-Associated Virus Vector Delivery of Opsins to Spiral Ganglion Neurons: Implications for Optogenetic Cochlear Implants.” Molecular Therapy: The Journal of the American Society of Gene Therapy 26, no. 8 (August 1, 2018): 1931–39. https://doi.org/10.1016/j.ymthe.2018.05.023.

Sagers, Jessica E., Lukas D. Landegger, Steven Worthington, Joseph B. Nadol, and Konstantina M. Stankovic. “Human Cochlear Histopathology Reflects Clinical Signatures of Primary Neural Degeneration.” Scientific Reports 7, no. 1 (July 7, 2017): 4884. https://doi.org/10.1038/s41598-017-04899-9.

Lin, Brian M., Wen-Qing Li, Sharon G. Curhan, Konstantina M. Stankovic, Abrar A. Qureshi, and Gary C. Curhan. “Skin Pigmentation and Risk of Hearing Loss in Women.” American Journal of Epidemiology 186, no. 1 (July 1, 2017): 1–10. https://doi.org/10.1093/aje/kwx024.

Landegger, Lukas D., Sonam Dilwali, and Konstantina M. Stankovic. “Neonatal Murine Cochlear Explant Technique as an In Vitro Screening Tool in Hearing Research.” Journal of Visualized Experiments: JoVE, no. 124 (June 8, 2017). https://doi.org/10.3791/55704.

Landegger, Lukas D., Bifeng Pan, Charles Askew, Sarah J. Wassmer, Sarah D. Gluck, Alice Galvin, Ruth Taylor, et al. “A Synthetic AAV Vector Enables Safe and Efficient Gene Transfer to the Mammalian Inner Ear.” Nature Biotechnology 35, no. 3 (March 2017): 280–84. https://doi.org/10.1038/nbt.3781.

Lin, Brian M., Sharon G. Curhan, Molin Wang, Brian C. Jacobson, Roland Eavey, Konstantina M. Stankovic, and Gary C. Curhan. “Prospective Study of Gastroesophageal Reflux, Use of Proton Pump Inhibitors and H2-Receptor Antagonists, and Risk of Hearing Loss.” Ear and Hearing 38, no. 1 (February 2017): 21–27. https://doi.org/10.1097/AUD.0000000000000347.

Lin, Brian M., Sharon G. Curhan, Molin Wang, Roland Eavey, Konstantina M. Stankovic, and Gary C. Curhan. “Duration of Analgesic Use and Risk of Hearing Loss in Women.” American Journal of Epidemiology 185, no. 1 (January 1, 2017): 40–47. https://doi.org/10.1093/aje/kww154.

Groth, Jane Bjerg, Shyan-Yuan Kao, Martijn C. Briët, and Konstantina M. Stankovic. “Hepatocyte Nuclear Factor-4 Alpha in Noise-Induced Cochlear Neuropathy.” Developmental Neurobiology 76, no. 12 (December 2016): 1374–86. https://doi.org/10.1002/dneu.22399.

Kao, Shyan-Yuan, Vitor Y. R. Soares, Arthur G. Kristiansen, and Konstantina M. Stankovic. “Activation of TRAIL-DR5 Pathway Promotes Sensorineural Degeneration in the Inner Ear.” Aging Cell 15, no. 2 (April 2016): 301–8. https://doi.org/10.1111/acel.12437.

———. “Hypertension, Diuretic Use, and Risk of Hearing Loss.” The American Journal of Medicine 129, no. 4 (April 2016): 416–22. https://doi.org/10.1016/j.amjmed.2015.11.014.

Curhan, Sharon G., Konstantina M. Stankovic, Roland D. Eavey, Molin Wang, Meir J. Stampfer, and Gary C. Curhan. “Carotenoids, Vitamin A, Vitamin C, Vitamin E, and Folate and Risk of Self-Reported Hearing Loss in Women.” The American Journal of Clinical Nutrition 102, no. 5 (November 2015): 1167–75. https://doi.org/10.3945/ajcn.115.109314.

Kao, Shyan-Yuan, and Konstantina M. Stankovic. “Transactivation of Human Osteoprotegerin Promoter by GATA-3.” Scientific Reports 5 (July 28, 2015): 12479. https://doi.org/10.1038/srep12479.

Jensen, Jane Bjerg, Andrew C. Lysaght, M. Charles Liberman, Klaus Qvortrup, and Konstantina M. Stankovic. “Immediate and Delayed Cochlear Neuropathy after Noise Exposure in Pubescent Mice.” PloS One 10, no. 5 (2015): e0125160. https://doi.org/10.1371/journal.pone.0125160.

Balasubramanian, Ravikumar, Jin-Ho Choi, Ludmila Francescatto, Jason Willer, Edward R. Horton, Eleni P. Asimacopoulos, Konstantina M. Stankovic, et al. “Functionally Compromised CHD7 Alleles in Patients with Isolated GnRH Deficiency.” Proceedings of the National Academy of Sciences of the United States of America 111, no. 50 (December 16, 2014): 17953–58. https://doi.org/10.1073/pnas.1417438111.

Platt, Michael, Sonam Dilwali, Alphi Elackattu, Jignesh R. Parikh, and Konstantina M. Stankovic. “Mining Immune Epitopes in the Inner Ear.” Otolaryngology–Head and Neck Surgery 150, no. 3 (March 2014): 460–63. https://doi.org/10.1177/0194599813514725.

Muurling, Tjeerd, and Konstantina M. Stankovic. “Metabolomic and Network Analysis of Pharmacotherapies for Sensorineural Hearing Loss.” Otology & Neurotology 35, no. 1 (January 2014): 1–6. https://doi.org/10.1097/MAO.0000000000000254.

Lysaght, Andrew C., Quan Yuan, Yi Fan, Neil Kalwani, Paul Caruso, MaryBeth Cunnane, Beate Lanske, and Konstantina M. Stanković. “FGF23 Deficiency Leads to Mixed Hearing Loss and Middle Ear Malformation in Mice.” PloS One 9, no. 9 (2014): e107681. https://doi.org/10.1371/journal.pone.0107681.

Kao, Shyan-Yuan, Judith S. Kempfle, Jane B. Jensen, Deborah Perez-Fernandez, Andrew C. Lysaght, Albert S. Edge, and Konstantina M. Stankovic. “Loss of Osteoprotegerin Expression in the Inner Ear Causes Degeneration of the Cochlear Nerve and Sensorineural Hearing Loss.” Neurobiology of Disease 56 (August 2013): 25–33. https://doi.org/10.1016/j.nbd.2013.04.008.

Stamatiou, Georgios A., and Konstantina M. Stankovic. “A Comprehensive Network and Pathway Analysis of Human Deafness Genes.” Otology & Neurotology 34, no. 5 (July 2013): 961–70. https://doi.org/10.1097/MAO.0b013e3182898272.

Lysaght, Andrew C., Shyan-Yuan Kao, Joao A. Paulo, Saumil N. Merchant, Hanno Steen, and Konstantina M. Stankovic. “Proteome of Human Perilymph.” Journal of Proteome Research 10, no. 9 (September 2, 2011): 3845–51. https://doi.org/10.1021/pr200346q.

Stankovic, Konstantina M., Ann Marie Hennessey, Barbara Herrmann, and Leila A. Mankarious. “Cochlear Implantation in Children with Congenital X-Linked Deafness Due to Novel Mutations in POU3F4 Gene.” Annals of Otology, Rhinology & Laryngology 119, no. 12 (December 2010): 815–22. https://doi.org/10.1177/000348941011901205.

Sugawara, Mitsuru, Joshua C. Murtie, Konstantina M. Stankovic, M. Charles Liberman, and Gabriel Corfas. “Dynamic Patterns of Neurotrophin 3 Expression in the Postnatal Mouse Inner Ear.” The Journal of Comparative Neurology 501, no. 1 (March 1, 2007): 30–37. https://doi.org/10.1002/cne.21227.

Stankovic, K. “Survival of Adult Spiral Ganglion Neurons Requires ErbB Receptor Signaling in the Inner Ear.” Journal of Neuroscience 24, no. 40 (October 6, 2004): 8651–61. https://doi.org/10.1523/JNEUROSCI.0733-04.2004.

Stankovic, Konstantina M., and Gabriel Corfas. “Real-Time Quantitative RT-PCR for Low-Abundance Transcripts in the Inner Ear: Analysis of Neurotrophic Factor Expression.” Hearing Research 185, no. 1–2 (November 2003): 97–108. https://doi.org/10.1016/s0378-5955(03)00298-3.

Stankovic, K. M., and J. J. Guinan. “Medial Efferent Effects on Auditory-Nerve Responses to Tail-Frequency Tones II: Alteration of Phase.” The Journal of the Acoustical Society of America 108, no. 2 (August 2000): 664–78. https://doi.org/10.1121/1.429599.

Stankovic, Konstantina M., and John J. Guinan. “Medial Efferent Effects on Auditory-Nerve Responses to Tail-Frequency Tones. I. Rate Reduction.” The Journal of the Acoustical Society of America 106, no. 2 (August 1999): 857–69. https://doi.org/10.1121/1.427102.

Stanković, Konstantina M., Dennis Brown, Seth L. Alper, and Joe C. Adams. “Localization of PH Regulating Proteins H+ATPase and Exchanger in the Guinea Pig Inner Ear.” Hearing Research 114, no. 1–2 (December 1997): 21–34. https://doi.org/10.1016/S0378-5955(97)00072-5.

Guinan, J. J., and K. M. Stankovic. “Medial Efferent Inhibition Produces the Largest Equivalent Attenuations at Moderate to High Sound Levels in Cat Auditory-Nerve Fibers.” The Journal of the Acoustical Society of America 100, no. 3 (September 1996): 1680–90. https://doi.org/10.1121/1.416066.

Stanković, K. M., J. C. Adams, and D. Brown. “Immunolocalization of Aquaporin CHIP in the Guinea Pig Inner Ear.” The American Journal of Physiology 269, no. 6 Pt 1 (December 1995): C1450-1456. https://doi.org/10.1152/ajpcell.1995.269.6.C1450.

Vestibular Schwannoma (Acoustic Neuroma)

Ren, Yin, Divya A. Chari, Sasa Vasilijic, D. Bradley Welling, and Konstantina M. Stankovic. “New Developments in Neurofibromatosis Type 2 and Vestibular Schwannoma.” Neuro-Oncology Advances 3, no. 1 (December 2021): vdaa153. https://doi.org/10.1093/noajnl/vdaa153.

Ren, Yin, Rosh K. V. Sethi, and Konstantina M. Stankovic. “National Trends in Surgical Resection of Vestibular Schwannomas.” Otolaryngology--Head and Neck Surgery: Official Journal of American Academy of Otolaryngology-Head and Neck Surgery 163, no. 6 (December 2020): 1244–49. https://doi.org/10.1177/0194599820932148.

Sagers, Jessica E., Roberta L. Beauchamp, Yanling Zhang, Sasa Vasilijic, Limeng Wu, Patrick DeSouza, Richard Seist, et al. “Combination Therapy with MTOR Kinase Inhibitor and Dasatinib as a Novel Therapeutic Strategy for Vestibular Schwannoma.” Scientific Reports 10, no. 1 (December 2020): 4211. https://doi.org/10.1038/s41598-020-60156-6.

Early, Samuel, Charlotte E. Rinnooy Kan, Maura Eggink, Johan H. M. Frijns, and Konstantina M. Stankovic. “Progression of Contralateral Hearing Loss in Patients With Sporadic Vestibular Schwannoma.” Frontiers in Neurology 11 (August 14, 2020): 796. https://doi.org/10.3389/fneur.2020.00796.

Ren, Yin, Hiroshi Hyakusoku, Jessica E. Sagers, Lukas D. Landegger, D. Bradley Welling, and Konstantina M. Stankovic. “MMP-14 (MT1-MMP) Is a Biomarker of Surgical Outcome and a Potential Mediator of Hearing Loss in Patients With Vestibular Schwannomas.” Frontiers in Cellular Neuroscience 14 (July 28, 2020): 191. https://doi.org/10.3389/fncel.2020.00191.

Sagers, Jessica E., Mehmet I. Sahin, InSeok Moon, Sherif G. Ahmed, Anat Stemmer-Rachamimov, Gary J. Brenner, and Konstantina M. Stankovic. “NLRP3 Inflammasome Activation in Human Vestibular Schwannoma: Implications for Tumor-Induced Hearing Loss.” Hearing Research 381 (September 2019): 107770. https://doi.org/10.1016/j.heares.2019.07.007.

Buch, Karen, Amy Juliano, Konstantina M. Stankovic, Hugh D. Curtin, and Mary Beth Cunnane. “Noncontrast Vestibular Schwannoma Surveillance Imaging Including an MR Cisternographic Sequence: Is There a Need for Postcontrast Imaging?” Journal of Neurosurgery 131, no. 2 (August 2019): 549–54. https://doi.org/10.3171/2018.3.JNS1866.

Ahmed, Sherif G, Ahmed Abdelnabi, Casey A Maguire, Mohamed Doha, Jessica E Sagers, Rebecca M Lewis, Alona Muzikansky, et al. “Gene Therapy with Apoptosis-Associated Speck-like Protein, a Newly Described Schwannoma Tumor Suppressor, Inhibits Schwannoma Growth in Vivo.” Neuro-Oncology 21, no. 7 (July 11, 2019): 854–66. https://doi.org/10.1093/neuonc/noz065.

Chen, Jie, Lukas D. Landegger, Yao Sun, Jun Ren, Nir Maimon, Limeng Wu, Mei R. Ng, et al. “A Cerebellopontine Angle Mouse Model for the Investigation of Tumor Biology, Hearing, and Neurological Function in NF2-Related Vestibular Schwannoma.” Nature Protocols 14, no. 2 (February 2019): 541–55. https://doi.org/10.1038/s41596-018-0105-7.

Sagers, Jessica E., Adam S. Brown, Sasa Vasilijic, Rebecca M. Lewis, Mehmet I. Sahin, Lukas D. Landegger, Roy H. Perlis, et al. “Computational Repositioning and Preclinical Validation of Mifepristone for Human Vestibular Schwannoma.” Scientific Reports 8, no. 1 (December 2018): 5437. https://doi.org/10.1038/s41598-018-23609-7.

Ren, Yin, and Konstantina M. Stankovic. “The Role of Tumor Necrosis Factor Alpha (TNFα)in Hearing Loss and Vestibular Schwannomas.” Current Otorhinolaryngology Reports 6, no. 1 (March 2018): 15–23. https://doi.org/10.1007/s40136-018-0186-4.

Zhao, Yingchao, Pinan Liu, Na Zhang, Jie Chen, Lukas D. Landegger, Limeng Wu, Fu Zhao, et al. “Targeting the CMET Pathway Augments Radiation Response without Adverse Effect on Hearing in NF2 Schwannoma Models.” Proceedings of the National Academy of Sciences 115, no. 9 (February 27, 2018): E2077–84. https://doi.org/10.1073/pnas.1719966115.

Landegger, Lukas D., Jong D. Lee, Fred H. Linthicum, and Konstantina M. Stankovic. “Cochlear Dysfunction Is Not Common in Human Meningioma of the Internal Auditory Canal.” Otology & Neurotology: Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology 38, no. 10 (December 2017): e486–89. https://doi.org/10.1097/MAO.0000000000001582.

Ren, Yin, Jessica E. Sagers, Lukas D. Landegger, Sangeeta N. Bhatia, and Konstantina M. Stankovic. “Tumor-Penetrating Delivery of SiRNA against TNFα to Human Vestibular Schwannomas.” Scientific Reports 7, no. 1 (December 2017): 12922. https://doi.org/10.1038/s41598-017-13032-9.

Landegger, Lukas D., Jessica E. Sagers, Sonam Dilwali, Takeshi Fujita, Mehmet I. Sahin, and Konstantina M. Stankovic. “A Unified Methodological Framework for Vestibular Schwannoma Research.” Journal of Visualized Experiments: JoVE, no. 124 (June 20, 2017). https://doi.org/10.3791/55827.

Kim, Bo Gyung, Takeshi Fujita, Konstantina M. Stankovic, D. Bradley Welling, In Seok Moon, Jae Young Choi, Jieun Yun, Jong Soon Kang, and Jong Dae Lee. “Sulforaphane, a Natural Component of Broccoli, Inhibits Vestibular Schwannoma Growth in Vitro and in Vivo.” Scientific Reports 6 (November 2, 2016): 36215. https://doi.org/10.1038/srep36215.

Soares, Vitor Y. R., Nadia A. Atai, Takeshi Fujita, Sonam Dilwali, Sarada Sivaraman, Lukas D. Landegger, Fred H. Hochberg, et al. “Extracellular Vesicles Derived from Human Vestibular Schwannomas Associated with Poor Hearing Damage Cochlear Cells.” Neuro-Oncology 18, no. 11 (November 2016): 1498–1507. https://doi.org/10.1093/neuonc/now099.

Kandathil, Cherian K., Mary E. Cunnane, Michael J. McKenna, Hugh D. Curtin, and Konstantina M. Stankovic. “Correlation Between Aspirin Intake and Reduced Growth of Human Vestibular Schwannoma: Volumetric Analysis.” Otology & Neurotology 37, no. 9 (October 2016): 1428–34. https://doi.org/10.1097/MAO.0000000000001180.

Dilwali, Sonam, Lukas D. Landegger, Vitor Y. R. Soares, Daniel G. Deschler, and Konstantina M. Stankovic. “Secreted Factors from Human Vestibular Schwannomas Can Cause Cochlear Damage.” Scientific Reports 5 (December 22, 2015): 18599. https://doi.org/10.1038/srep18599.

Dilwali, Sonam, Martijn C. Briët, Shyan-Yuan Kao, Takeshi Fujita, Lukas D. Landegger, Michael P. Platt, and Konstantina M. Stankovic. “Preclinical Validation of Anti-Nuclear Factor-Kappa B Therapy to Inhibit Human Vestibular Schwannoma Growth.” Molecular Oncology 9, no. 7 (August 2015): 1359–70. https://doi.org/10.1016/j.molonc.2015.03.009.

Dilwali, Sonam, Shyan-Yuan Kao, Takeshi Fujita, Lukas D. Landegger, and Konstantina M. Stankovic. “Nonsteroidal Anti-Inflammatory Medications Are Cytostatic against Human Vestibular Schwannomas.” Translational Research: The Journal of Laboratory and Clinical Medicine 166, no. 1 (July 2015): 1–11. https://doi.org/10.1016/j.trsl.2014.12.007.

Dilwali, Sonam, Daniel Roberts, and Konstantina M. Stankovic. “Interplay between VEGF-A and CMET Signaling in Human Vestibular Schwannomas and Schwann Cells.” Cancer Biology & Therapy 16, no. 1 (2015): 170–75. https://doi.org/10.4161/15384047.2014.972765.

Dilwali, Sonam, Pratik B. Patel, Daniel S. Roberts, Gina M. Basinsky, Gordon J. Harris, Kevin S. Emerick, and Konstantina M. Stankovic. “Primary Culture of Human Schwann and Schwannoma Cells: Improved and Simplified Protocol.” Hearing Research 315 (September 2014): 25–33. https://doi.org/10.1016/j.heares.2014.05.006.

Kandathil, Cherian K., Sonam Dilwali, Chen-Chi Wu, Metin Ibrahimov, Michael J. McKenna, Hang Lee, and Konstantina M. Stankovic. “Aspirin Intake Correlates With Halted Growth of Sporadic Vestibular Schwannoma In Vivo.” Otology & Neurotology 35, no. 2 (February 2014): 353–57. https://doi.org/10.1097/MAO.0000000000000189.

Dilwali, Sonam, Andrew Lysaght, Daniel Roberts, Fred G. Barker, Michael J. McKenna, and Konstantina M. Stankovic. “Sporadic Vestibular Schwannomas Associated with Good Hearing Secrete Higher Levels of Fibroblast Growth Factor 2 than Those Associated with Poor Hearing Irrespective of Tumor Size.” Otology & Neurotology: Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology 34, no. 4 (June 2013): 748–54. https://doi.org/10.1097/MAO.0b013e31828048ec.

Gómez-Casati, Maria E., Joshua C. Murtie, Carlos Rio, Konstantina Stankovic, M. Charles Liberman, and Gabriel Corfas. “Nonneuronal Cells Regulate Synapse Formation in the Vestibular Sensory Epithelium via ErbB-Dependent BDNF Expression.” Proceedings of the National Academy of Sciences of the United States of America 107, no. 39 (September 28, 2010): 17005–10. https://doi.org/10.1073/pnas.1008938107.

Stankovic, Konstantina M., Maciej M. Mrugala, Robert L. Martuza, Michael Silver, Rebecca A. Betensky, Joseph B. Nadol, and Anat O. Stemmer-Rachamimov. “Genetic Determinants of Hearing Loss Associated With Vestibular Schwannomas.” Otology & Neurotology 30, no. 5 (August 2009): 661–67. https://doi.org/10.1097/MAO.0b013e3181a66ece.

Optical Imaging of the Inner Ear

Romito, Marilisa, Ye Pu, Konstantina M. Stankovic, and Demetri Psaltis. “Imaging Hair Cells through Laser-Ablated Cochlear Bone.” Biomedical Optics Express 10, no. 11 (November 1, 2019): 5974–88. https://doi.org/10.1364/BOE.10.005974.

Bommakanti, Krishna, Janani S. Iyer, and Konstantina M. Stankovic. “Cochlear Histopathology in Human Genetic Hearing Loss: State of the Science and Future Prospects.” Hearing Research 382 (October 2019): 107785. https://doi.org/10.1016/j.heares.2019.107785.

Kakkava, Eirini, Marilisa Romito, Donald B. Conkey, Damien Loterie, Konstantina M. Stankovic, Christophe Moser, and Demetri Psaltis. “Selective Femtosecond Laser Ablation via Two-Photon Fluorescence Imaging through a Multimode Fiber.” Biomedical Optics Express 10, no. 2 (February 1, 2019): 423. https://doi.org/10.1364/BOE.10.000423.

———. “Selective Femtosecond Laser Ablation via Two-Photon Fluorescence Imaging through a Multimode Fiber.” Biomedical Optics Express 10, no. 2 (February 1, 2019): 423–33. https://doi.org/10.1364/BOE.10.000423.

Iyer, Janani S., Ning Zhu, Sergei Gasilov, Hanif M. Ladak, Sumit K. Agrawal, and Konstantina M. Stankovic. “Visualizing the 3D Cytoarchitecture of the Human Cochlea in an Intact Temporal Bone Using Synchrotron Radiation Phase Contrast Imaging.” Biomedical Optics Express 9, no. 8 (August 1, 2018): 3757–67. https://doi.org/10.1364/BOE.9.003757.

Iyer, Janani S., Shelley A. Batts, Kengyeh K. Chu, Mehmet I. Sahin, Hui Min Leung, Guillermo J. Tearney, and Konstantina M. Stankovic. “Micro-Optical Coherence Tomography of the Mammalian Cochlea.” Scientific Reports 6 (September 16, 2016): 33288. https://doi.org/10.1038/srep33288.

Fujita, Takeshi, Jung Eun Shin, MaryBeth Cunnane, Kyoko Fujita, Simon Henein, Demetri Psaltis, and Konstantina M. Stankovic. “Surgical Anatomy of the Human Round Window Region: Implication for Cochlear Endoscopy Through the External Auditory Canal.” Otology & Neurotology: Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology 37, no. 8 (September 2016): 1189–94. https://doi.org/10.1097/MAO.0000000000001074.

Landegger, Lukas D., Demetri Psaltis, and Konstantina M. Stankovic. “Human Audiometric Thresholds Do Not Predict Specific Cellular Damage in the Inner Ear.” Hearing Research 335 (May 2016): 83–93. https://doi.org/10.1016/j.heares.2016.02.018.

Low, Jacob C. M., Thomas J. Ober, Gareth H. McKinley, and Konstantina M. Stankovic. “Quantitative Polarized Light Microscopy of Human Cochlear Sections.” Biomedical Optics Express 6, no. 2 (February 1, 2015): 599–606. https://doi.org/10.1364/BOE.6.000599.

Kalwani, Neil M., Cheng Ai Ong, Andrew C. Lysaght, Simon J. Haward, Gareth H. McKinley, and Konstantina M. Stankovic. “Quantitative Polarized Light Microscopy of Unstained Mammalian Cochlear Sections.” Journal of Biomedical Optics 18, no. 2 (February 2013): 26021. https://doi.org/10.1117/1.JBO.18.2.026021.

Yang, Xin, Ye Pu, Demetri Psaltis, and Konstantina M. Stankovic. “In Situ Imaging of the Mouse Cochlea Using Two-Photon Microscopy.” edited by Pietro Ferraro, Monika Ritsch-Marte, Simonetta Grilli, and David Stifter, 87920T. Munich, Germany, 2013. https://doi.org/10.1117/12.2022523.

Yang, Xin, Ye Pu, Chia-Lung Hsieh, Cheng Ai Ong, Demetri Psaltis, and Konstantina M. Stankovic. “Two-Photon Microscopy of the Mouse Cochlea in Situ for Cellular Diagnosis.” Journal of Biomedical Optics 18, no. 3 (November 19, 2012): 031104. https://doi.org/10.1117/1.JBO.18.3.031104.

Devices for Inner Ear Stimulation and Monitoring

Romito, Marilisa, Ye Pu, Konstantina M. Stankovic, and Demetri Psaltis. “Imaging Hair Cells through Laser-Ablated Cochlear Bone.” Biomedical Optics Express 10, no. 11 (November 1, 2019): 5974–88. https://doi.org/10.1364/BOE.10.005974.

Bommakanti, Krishna, Janani S. Iyer, and Konstantina M. Stankovic. “Cochlear Histopathology in Human Genetic Hearing Loss: State of the Science and Future Prospects.” Hearing Research 382 (October 2019): 107785. https://doi.org/10.1016/j.heares.2019.107785.

Kakkava, Eirini, Marilisa Romito, Donald B. Conkey, Damien Loterie, Konstantina M. Stankovic, Christophe Moser, and Demetri Psaltis. “Selective Femtosecond Laser Ablation via Two-Photon Fluorescence Imaging through a Multimode Fiber.” Biomedical Optics Express 10, no. 2 (February 1, 2019): 423. https://doi.org/10.1364/BOE.10.000423.

———. “Selective Femtosecond Laser Ablation via Two-Photon Fluorescence Imaging through a Multimode Fiber.” Biomedical Optics Express 10, no. 2 (February 1, 2019): 423–33. https://doi.org/10.1364/BOE.10.000423.

Iyer, Janani S., Ning Zhu, Sergei Gasilov, Hanif M. Ladak, Sumit K. Agrawal, and Konstantina M. Stankovic. “Visualizing the 3D Cytoarchitecture of the Human Cochlea in an Intact Temporal Bone Using Synchrotron Radiation Phase Contrast Imaging.” Biomedical Optics Express 9, no. 8 (August 1, 2018): 3757–67. https://doi.org/10.1364/BOE.9.003757.

Iyer, Janani S., Shelley A. Batts, Kengyeh K. Chu, Mehmet I. Sahin, Hui Min Leung, Guillermo J. Tearney, and Konstantina M. Stankovic. “Micro-Optical Coherence Tomography of the Mammalian Cochlea.” Scientific Reports 6 (September 16, 2016): 33288. https://doi.org/10.1038/srep33288.

Fujita, Takeshi, Jung Eun Shin, MaryBeth Cunnane, Kyoko Fujita, Simon Henein, Demetri Psaltis, and Konstantina M. Stankovic. “Surgical Anatomy of the Human Round Window Region: Implication for Cochlear Endoscopy Through the External Auditory Canal.” Otology & Neurotology: Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology 37, no. 8 (September 2016): 1189–94. https://doi.org/10.1097/MAO.0000000000001074.

Landegger, Lukas D., Demetri Psaltis, and Konstantina M. Stankovic. “Human Audiometric Thresholds Do Not Predict Specific Cellular Damage in the Inner Ear.” Hearing Research 335 (May 2016): 83–93. https://doi.org/10.1016/j.heares.2016.02.018.

Low, Jacob C. M., Thomas J. Ober, Gareth H. McKinley, and Konstantina M. Stankovic. “Quantitative Polarized Light Microscopy of Human Cochlear Sections.” Biomedical Optics Express 6, no. 2 (February 1, 2015): 599–606. https://doi.org/10.1364/BOE.6.000599.

Kalwani, Neil M., Cheng Ai Ong, Andrew C. Lysaght, Simon J. Haward, Gareth H. McKinley, and Konstantina M. Stankovic. “Quantitative Polarized Light Microscopy of Unstained Mammalian Cochlear Sections.” Journal of Biomedical Optics 18, no. 2 (February 2013): 26021. https://doi.org/10.1117/1.JBO.18.2.026021.

Yang, Xin, Ye Pu, Demetri Psaltis, and Konstantina M. Stankovic. “In Situ Imaging of the Mouse Cochlea Using Two-Photon Microscopy.” edited by Pietro Ferraro, Monika Ritsch-Marte, Simonetta Grilli, and David Stifter, 87920T. Munich, Germany, 2013. https://doi.org/10.1117/12.2022523.

Yang, Xin, Ye Pu, Chia-Lung Hsieh, Cheng Ai Ong, Demetri Psaltis, and Konstantina M. Stankovic. “Two-Photon Microscopy of the Mouse Cochlea in Situ for Cellular Diagnosis.” Journal of Biomedical Optics 18, no. 3 (November 19, 2012): 031104. https://doi.org/10.1117/1.JBO.18.3.031104.

The Otic Capsule and Middle Ear: Pathophysiology

Robertson NG, O’Malley JT, Ong AI, Giersch AB, Shen J, Stankovic KM, Morton CC. Cochlin in Normal Middle Ear and Abnormal Middle Ear Deposits in DFNA9 and CochG88E/ G88E Mice. J. Assoc Res Otolaryngol 2014; 15(6):961-74.

Stankovic KM, Adachi O, Tsuji K, Kristiansen AG, Adams JC, Rosen V, McKenna MJ. Differences in Gene Expression Between the Otic Capsule and Other Bones. Hearing Research 2010; 265 (1-2): 83-9; featured on cover page.

Stankovic KM, Kristiansen AG, Bizaki A, Lister M, Adams JC, McKenna MJ. Studies of Otic Capsule Morphology and Gene Expression in the Mov13 Mouse – an Animal Model of Type I Osteogenesis Imperfecta. Audiology & Neurotology. 2007; 12(5): 334-43.

Stankovic KM, McKenna MJ. Current Research in Otosclerosis. Current Opinion in ORL – Head Neck Surgery 2006;14:347-351.

Sinonasal Polyposis: Molecular Insights

Lehmann AE, Scangas GA, Bergmark RW, Rassi EE, Stankovic KM, Metson R. Periostin and inflammatory disease – implications for chronic rhinosinusitis. Otolaryngology – Head and Neck Surgery. 2019. 194599819838782. doi: 10.1177/0194599819838782. [Epub ahead of print].

Maxfield AZ, Landegger LD, Brook CD, Lehmann AE, Campbell A, Bergmark RW, Stankovic KM+, Metson R+. Periostin as a Biomarker for Nasal Polyps in Chronic Rhinosinusitis. Otolaryngology – Head and Neck Surgery. 2017 Oct 1:194599817737967. 

Brook C, Maxfield AZ, Stankovic KM, Metson R. The Impact of Angiotensin-Modulating Antihypertensives on Time Interval to Revision Surgery for Nasal Polyps. Otolaryngology-Head and Neck Surgery. Otolaryngology – Head and Neck Surgery 2016;155(6):1046-1052.

Platt M, Soler Z, Kao SY, Metson R, Stankovic KM. Topographic Gene Expression in the Sinonasal Cavity of Patients with Chronic Sinusitis with Polyps. Otolaryngology-Head & Neck Surgery 2011; 145(1):171-5.

Platt M, Soler Z, Metson R, Stankovic KM. Pathways Analysis of Molecular Markers in Chronic Sinusitis with Polyps. Otolaryngology-Head & Neck Surgery. 2011; 144(5):802-8; featured on cover page.

Platt M, Metson R, Stankovic KM. Gene Expression Signatures of Nasal Polyps Associated with Chronic Sinusitis and Aspirin-Sensitive Asthma. Current Opinion in Allergy and Clinical Immunology 2009; 9(1):23-8.

Stankovic KM, Goldsztein G, Reh D, Platt M, Metson R. Gene Expression Profiling of Nasal Polyps Associated with Chronic Sinusitis and Aspirin-Sensitive Asthma. Laryngoscope 2008; 118(5): 881-9; featured on cover page.

Clinical Communications

Santos F, Shu E, Lee D, Jung D, Quesnel A, Stankovic KM, Abdul-Aziz D, Quinkert A, Welling DB. Topical fibroblast growth factor-2 for treatment of chronic tympanic membrane perforations. Laryngoscope Investigative Otolaryngology. May 14, 2020.

Masud SF, Knudson IM, Stankovic KM, Nakajima HH. Fracture of the incus caused by digital manipulation of the ear canal and its diagnosis using wideband acoustic immittance. Otology and Neurotology. 2018;40:e115-e118. [Epub ahead of print] +equal contribution.

Stankovic KM, Tan OT, Sadow PM. Case Records of the Massachusetts General Hospital. Case 36-2015. A 27-Year-Old Woman with a Lesion of the Ear Canal. New England Journal of Medicine. 2015 Nov 19;373(21):2070-7.

Stankovic KM, Eskandar E, ElKhoury J, Lev M, Sadow PM. A 20-Year-Old Man with Chronic Otitis Media, Fever and Headache. New England Journal of Medicine 2013; 368(3): 267-77.

Lin H, Roberts D, Kay J, Stankovic KM. Hearing Loss Following Imatinib (Gleevec) Administration. Otolaryngology-Head and Neck Surg. 2012; 146(2):335-7.

Stankovic KM, Juliano AF, Hasserjian RP. A 50-Year-Old Woman with Loss of Hearing, Pain and a Mass in the Left Ear. New England Journal of Medicine 2010; 363(22): 2146-56.