Project Probiotic

The purpose of this study was to  see how a probiotic supplement would affect the composition of your microbiota, your immune health, and the  feelings of health and well-being.

Eligible Participants

Eligble participants in this study were required to meet the following criteria:

  • 18 years and older, both men and women
  • Have a BMI of <40
  • Have some of the following risk factors: high blood pressure, high glucose, high cholesterol, or large waist circumference, but otherwise in good health (we will screen you for these)
  • Do not currently suffer from gastrointestinal symptoms such as diarrhea, constipation, bloating, or IBS

Study Design

Participation in this study required:

  • Attending 8 clinic visits over an 18-week period (30 minutes each).
  • Maintaining dietary food records throughout the study.
  • Providing blood, stool, and urine samples, and complete questionnaires asking about feelings of health and wellbeing.
  • Taking a probiotic supplement or a placebo (as determined by randomization) for 10 weeks.


Upon completion, participants received: 

  • Results of the blood analyses
  • A “map” of your microbiota composition


In this study, we did not observe any improvement in metabolic syndrome parameters, nor a decrease in inflammatory markers with consumption of a probiotic supplement for 18 weeks. However, we observed lowered triglycerides and diastolic blood pressure in a subset of participants in the probiotic group (probiotic responders). In the remaining participants in the probiotic group (non-responders), we observed higher levels of blood glucose and insulin, suggesting a detrimental effect. 


The study results were published in the journal Gut Microbes ( in January, 2023.