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Medical Research July 05, 2018

The beating brain: A video captures the organ's rhythmic pulsations

By Bruce Goldman

A group of researchers have developed an imaging method to show the brain in motion.

Here you were, figuring your brain just sits still inside your head purring like a kitten in grandma's lap, and along comes science and catches this "most complicated object in the known universe" in the act of jerking around like a catfish on a pole.

Don't believe me? Check out the "jumpy brain" video below. It's only several seconds long. But that should be enough to change your mind.

Okay. Actually, your brain doesn't really jump around all that much inside your skull, although it does rhythmically bulge and shrink with each heartbeat, by an amount equivalent to a bit less the width of a human hair.

Nothing to see here, folks, just walk away. Except don't, because there is.

A study recently published in the journal Magnetic Resonance in Medicine and co-authored by Stanford life-science research assistant Itamar Terem, then-postdoc Samantha Jane Holdsworth, PhD, (now at the University of Auckland) and several other Stanford colleagues describes a new imaging method that, by means of a kind of strobe-action amplification technique, is able to visually blow up the minute heartbeat-induced pulsations of the brain to produce mind-boggling video sequences such as the one you've hopefully taken a peek at here.

There's medical value in this, because certain mental states and conditions are associated with an exaggerated brain-pulsation propensity. One of the two brains depicted in the video is from a normal brain; the other comes from an individual with a rare syndrome called Chiari I malformation, a complex of structural defects in the base of the skull and cerebellum. The new imaging technique may prove useful someday in diagnosing not only this but other structural brain abnormalities, as well as concussion and aneurysms.

The video and the study underlying it were impressive enough to be featured recently on the blog of National Institutes of Health Director Francis Collins, MD, PhD.

Video by Itamar Terem and Samantha Jane Holdsworth

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Senior science writer

Bruce Goldman

Bruce Goldman, MS, is a senior science writer in the Office of Communications. He covers immunology, infectious disease, transplantation, neurosciences, neurosurgery, bioengineering, molecular and cellular physiology, and biochemistry. A recovering philosophy major from the University of Wisconsin, he’s done his best to cover his tracks by obtaining yet another bachelor’s degree, this time in engineering physics from the University of Colorado, and attending finishing school, in cell biology, at Harvard University, where he received an award for his teaching of an undergraduate biology course. Articles he has written while at Stanford Medicine have won well over a dozen awards from the Association of American Medical Colleges and the Council for Advancement and Support of Education. He is a member of the National Association of Science Writers and the co-author of two books about the future: 2020 Visions: Long View of a Changing World (Portable Stanford) and Fast Forward (Harper). Once upon a time, he drove a car to Afghanistan. He can play guitar with his toes, but only while fast asleep and dreaming.