Neurosurgery Clinical Trials
The Stanford Department of Neurosurgery is at the forefront of clinical trials, offering potential therapies not offered anywhere else in the world. Our studies examine therapies for everything from brain trauma and spinal cord injury to pediatric brain tumors and stroke. The results of these studies and the discoveries in our labs translate into new, innovative, and minimally-invasive therapies for patients.
Brain Tumor
Newly Diagnosed Glioma
A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of Optune® (TTFields, 200 kHz) concomitant with Maintenance Temozolomide and Pembrolizumab Versus Optune® Concomitant with Maintenance Temozolomide and Placebo for the Treatment of Newly Diagnosed Glioblastoma (EF-41/KEYNOTE D58)
PI: Lawrence Recht, MD
Research Coordinator: Sahara Rout
Contact: ssrout@stanford.edu
ClinicalTrials.gov#: NCT06556563
Phase 1 Clinical Trial of Autologous GD2 Chimeric Antigen Receptor (CAR) T Cells (GD2CART) for Diffuse Intrinsic Pontine Gliomas (DIPG) and Spinal Diffuse Midline Glioma (DMG)
PI: Michelle Monje, MD, PhD
Study Status: Recruiting
ClinicalTrials.gov#: NCT04196413
Recurrent High Grade Glioma
Phase I Clinical Trial of Locoregionally (LR) Delivered Autologous B7-H3 Chimeric Antigen Receptor T Cells (B7-H3CART) in Adults with Recurrent Glioblastoma Multiforme (GBM)
PI: Reena Thomas, MD PhD
Study Status: Recruiting
ClinicalTrials.gov#: NCT05474378
Phase I/II, Open-Label Study Evaluating the Efficacy and Pharmacokinetics of Panitumumab-IRDye800 as an Optical Imaging Agent to Detect Neoplasms during Neurosurgical Procedures
PI: Gordon Li, MD
Study Status: Recruiting
ClinicalTrials.gov#: NCT03510208
A Phase I Study of Multiple Doses of Neural Stem Cell-Based Oncolytic Virotherapy (NSC-CRAd-S-pk7) Administered Intracerebrally to Patients with Recurrent High Grade Gliomas
PI: Melanie Hayden Gephart, MD
Study Status: Recruiting
ClinicalTrials.gov#: NCT05139056
Brain and Spine Metastases
A Randomized Phase III TriaL Comparing SingLe- Versus Multi-Fraction Spine STereotActic Radiosurgery for Patients with Spinal Metastases (ALL-STAR)
PI: Erqi Pollum, MD
Study Status: Recruiting
ClinicalTrials.gov#: NCT06173401
Cerebrovascular Surgery
The Neuroscience Brain Bank: Collection of Neurosurgical Tissue for Research
PI: Gary Steinberg, MD
Study Status: Recruiting
Research Coordinator: Gabriella Morton
Contact: neurosurgeryresearch@stanford.edu
Endocrinology
A multi-national, multi-centre, prospective, single-arm, observational, non-interventional post-authorisation safety study to investigate long-term safety of Sogroya® (somapacitan) in adults with growth hormone deficiency (AGHD) under routine clinical practice (NN8640-4515)
PI: Julia Chang, MD
Study status: Active/Recruiting
Research Coordinator: Banu Priya
Contact: bpriya@stanford.edu
ClinicalTrials.gov#: NCT05718570
National US Pituitary Adenoma Surveillance Registry
PI: Julia Chang, MD
Study status: Active/Recruiting
Research Coordinator: Banu Priya
Contact: bpriya@stanford.edu
Endovascular
Safety and Efficacy of Endovascular Treatment of Intracranial Aneurysms with Surpass Elite with GUARDian Flow Diverter (GUARD)
PI: Robert Dodd, MD, PhD
Study Status: Active/Recruiting
Research Coordinator: Banu Priya
Contact: bpriya@stanford.edu
ClinicalTrials.gov#: NCT06872684
A multi-center, randomized, adaptive clinical trial comparing standard medical management to early surgical hematoma evacuation using minimally invasive trans-sulcal parafasicular surgery in the treatment of acute spontaneous anterior basal ganglia intracerebral hemorrhage (REACH)
PI: Robert Dodd, MD, PhD
Study Status: Waiting to open
Research Coordinator: Banu Priya
Contact: bpriya@stanford.edu
ClinicalTrials.gov#: NCT06870812
Functional Neurosurgery
BrainGate2: Feasibility Study of an Intracortical Neural System for Persons with Tetraplegia
PI: Jaimie Henderson, MD
Study Status: Recruiting
Research Coordinator: Guiping Qin
Contact: neurosurgeryresearch@stanford.edu
ClinicalTrials.gov#: NCT00912041
exPDite-2: A Phase 3 Study to Assess the Efficacy and Safety of Midbrain Dopaminergic Neuronal Cell Therapy (Bemdaneprocel) for Participants With Parkinson’s Disease
PI: Vivek Buch, MD
Study Status: Active/Recruiting (Surgery Only)
Research Coordinator: Banu Priya
Contact: bpriya@stanford.edu
ClinicalTrials.gov#: NCT06944522
Pediatric Neurosurgery
Childhood Brain Tumor Tissue Consortium (CBTTC) Collection protocol
PI: Laura Prolo, MD
Study Status: Recruiting
Research Coordinator: Gabriella Morton
Contact: neurosurgeryresearch@stanford.edu
Advancing Treatment for Pediatric Craniopharyngioma: Prospective Pilot Study Identifying Clinically Relevant Biological Targets for Medical Therapy
PI: Laura Prolo, MD
Study Status: Recruiting
Research Coordinator: Gabriella Morton
Contact: neurosurgeryresearch@stanford.edu
ClinicalTrials.gov#: NCT03610906
HCRN Core Data Project: Characterizing Patient Populations in the Hydrocephalus Clinical Research Network (HCRN)
PI: Kelly Mahaney, MD
Study Status: Recruiting
Research Coordinator: Gabriella Morton
Contact: neurosurgeryresearch@stanford.edu
ClinicalTrials.gov#: NCT00670735
Panitumumab-IRDye800 to Detect Pediatric Neoplasms During Neurosurgical Procedures
PI: Laura Prolo, MD
Study Status: Recruiting
Research Coordinator: Gabriella Morton
Contact: neurosurgeryresearch@stanford.edu
ClinicalTrials.gov#: NCT04085887
Renal Carcinoma
Non-interventional post-authorization study of belzutifan in adult patients with von Hippel-Lindau disease-associated renal cell carcinoma, pancreatic neuroendocrine tumor and/or central nervous system hemangioblastoma
PI: David Park , MD
Study status: Active/Recruiting
Research Coordinator: Banu Priya
Contact: bpriya@stanford.edu
Spine
COMPaSS (Clinical Outcome Measures in Personalized aprevo Spine Surgery) Registry
PI: Atman Desai, MD
Study status: Active/Not enrolling
Research Coordinator: Banu Priya
Contact: bpriya@stanford.edu