Spine Surgery Clinical Trials

Clinical Trials

North American Clinical Trials Network (NACTN)

The Department of Neurosurgery is a member of the North American Clinical Trials Network (NACTN) for Treatment of Spinal Cord Injury, whose mission is to bring promising therapies out of the laboratory and into clinical trials. A recent Phase I trial showed that the oral medication Riluzole may have some efficacy in reducing impairment if given during the first two weeks after spinal cord injury. A Phase II trial is now being planned to examine the safety and efficacy of Riluzole in more detail.

PI: Graham Creasey, MD
Status: Chart review, recruiting
Contact: Kara Richardson

The Canadian Multicentre CSF Monitoring and Biomarker Study (CAMPER)

The Department of Neurosurgery will this year become the first US site in this multi-center study supported by the Rick Hansen Institute of Canada to monitor pressure around the spinal cord during the first week after spinal cord injury and to sample cerebrospinal fluid for biomarkers of injury.

PI: John Ratliff, MD, FACS
Status: Not yet recruiting
Contact: Kara Richardson

Evaluation of Pudendal Nerve Block and Stimulation for Voiding and Continence

This Phase I four-year clinical trial supported by the Department of Defense will evaluate a second generation neural prosthesis for restoring bladder emptying and continence using electrical stimulation without posterior rhizotomy.

PI: Graham Creasey, MD
Status: Active, Recruiting
Contact:  Zoia Latev

Prospective, Concurrently Controlled, Multi-center Study to Evaluate the Safety and Effectiveness of the Spinal Kinetics M6-C Artificial Cervical Disc Compared to Anterior Cervical Discectomy and Fusion (ACDF) for the Treatment of Symptomatic Cervical Radiculopathy

This is a prospective, concurrently controlled, multi-center study to evaluate the safety and effectiveness of the Spinal Kinetics M6-C artificial cervical disc compared to anterior cervical discectomy and fusion (ACDF) for the treatment of symptomatic cervical radiculopathy with or without cord compression. Some participating sites will enroll just M6-C patients, while others will enroll just ACDF patients.

Patients eligible for study enrollment will present with degenerative cervical radiculopathy requiring surgical intervention, confirmed clinically and radiographically, at one vertebral level from C3 to C7.

Status: Closed to Enrollment, Activities Continuing
PI: Lawrence Shuer, MD
Contact: Kara Richardson

InVivo Study of Probable Benefit of the Neuro-Spinal Scaffold for Safety and Neurologic Recovery in Subjects with Complete Thoracic AIS A Spinal Cord Injury

The purpose of this study is to assess the safety of a new medical device which is implanted into the injured spinal cord for a recent spinal cord injury.

Status: Not recruiting
PI: Atman Desai, MD
Contact: Kara Richardson