Exploring the Gut-Brain Connection in Parkinson’s Disease

Grant Announcement at Stanford University: Exploring the Gut-Brain Connection in Parkinson’s Disease

Stanford University, in collaboration with leading institutions nationwide, is proud to announce the launch of a groundbreaking, NIH-funded study exploring the intricate relationship between the gastrointestinal system and Parkinson’s disease (PD). Spearheaded by Drs. Kathleen Poston and Laren Becker at Stanford, this multi-site initiative represents a major stride in unraveling the mysteries of non-motor symptoms in PD.

Gastrointestinal dysfunction, often predating motor symptoms, is a pervasive challenge for those living with PD. This innovative study will investigate how gut physiology, immune dynamics, and microbial composition contribute to disease onset and progression. It will also evaluate the presence of Lewy body pathology in the gut, a hallmark of PD, to advance our understanding of the gut-brain axis.

This multidisciplinary approach integrates clinical neurology, gastroenterology, bioengineering, and microbiome science. Stanford’s efforts are part of a collaborative network, with study sites at Rush University, Massachusetts General Hospital, the Mayo Clinic, and the University of Chicago, coordinated by Duke University. Together, this initiative has the potential to revolutionize early diagnostic and therapeutic strategies for PD.

We welcome the Stanford community and beyond to support and follow our journey as we uncover the critical connections between gut health and PD. For updates and recruitment opportunities, please stay tuned to the Stanford Movement Disorders Center.

January 2025