Meaghan Roy-O'Reilly, MD, PhD
- Adult Neurology Residency: Stanford (2021-2024)
- Internal Medicine, Preliminary Year: Stanford (2020-2021)
- MD/PhD: University of Texas Health Science Center at Houston/MD Anderson Cancer Center (2020)
- MS: University of Connecticut (2012)
- BS: University of Connecticut (2012)
- Clinical and translational research in neuro-oncology
- Aerospace medicine
McCullough LD, Roy-O’Reilly M et al. Exogenous inter-alpha inhibitor proteins prevent cell death and improve ischemic stroke outcomes in mice. Journal of Clinical Investigation. September 2021.
Manwani B, Fall P, Zhu L, Roy-O'Reilly M et al. Increased P450 aromatase levels in post-menopausal women after acute ischemic stroke. Biol Sex Differ. 2021;12(1):8.
Roy-O'Reilly M, Mulavara A, Williams T. A review of alterations to the brain during spaceflight and the potential relevance to crew in long-duration space exploration. NPJ Microgravity. 2021 Feb 16:(1):5.
Patrizz A, Doran SJ, Chauhan A, Ahnstedt H, Roy-O’Reilly M, Lai Y, Weston G, Tarabishy S, Patel AR, Verma R, Staff I, Kofler JK, Li J, et al. EMMPRIN/CD147 plays a detrimental role in clinical and experimental ischemic stroke. Aging (Albany NY). 2020.
Ahnstedt H, Patrizz A, Chauhan A, Roy-O’Reilly M, et al. Sex differences in T cell immune responses, gut permeability and outcome after ischemic stroke in aged mice. Brain Behav Immun. 2020.
Harris NM, Roy-O’Reilly M, Ritzel RM, et al. Depletion of CD4 T cells provides therapeutic benefits in aged mice after ischemic stroke. Exp Neurol. 2020;326:113202.
Roy-O’Reilly MA, Ahnstedt H, Spychala M, et al. Aging exacerbates neutrophil pathogenicity in ischemic stroke. Aging. 2020;12(1):436-461.
Howe MD, Furr JW, Munshi Y, Roy-O’Reilly MA, Maniskas ME, Koellhoffer EC, d’Aigle J, Sansing LH, McCullough LD, Urayama A. Transforming growth factor-B promotes basement membrane fibrosis, alters perivascular cerebrospinal fluid distribution, and worsens neurologic recovery in the aged brain after stroke. Geroscience. 2019 Oct;41(5): 543 – 559.
Ritzel RM, Mamun A, Crapser J, Verma R, Patel AR, Knight BE, Harris N, Mancini N, Roy-O’Reilly M, Ganesh BP, Liu F, McCullough LD. CD200-CD200R1 inhibitory signalling prevents spontaneous bacterial infection and promotes resolution of neuroinflammnation and recovery after stroke. Journal of Neuroinflammation. 2019. Feb 19; 16:40.
Aronowski JA, Roy-O’Reilly M. Basic Science Controversies: Neutrophils, the Felons of the Brain. Stroke. 2019. Mar; 50 (3): e42-e43.
Modak J, Roy-O’Reilly M, McCullough LD. Differential MicroRNA Expression in Cardioembolic Stroke. Journal of Stroke and Cerebrovascular Disease. 2019, Jan; 28 (1): 121 – 124.
Roy-O’Reilly M, Pham Q, McCullough LD. Sex Differences in Cerebral Ischemia. Sex Differences in Cardiovascular Physiology and Pathophysiology. ED: LaMarca B, Alexander B. Elsevier, 2019. Cambridge, MA.
Roy-O’Reilly M, McCullough LD. Age and Sex are Critical Factors in Ischemic Stroke Pathology. Endocrinology. 2018 Aug 1;159(8):3120-3131.
Ahnstedt H, Roy-O’Reilly M, Spychala M, Mobley A, Bravo-Alegria J, Chauhan A, Aronowski J, Marrelli S, McCullough LD. Sex Differences in Adipose Tissue CD8+ T Cells and Regulatory T Cells in Middle-Aged Mice. Front. Immunol. 2018 Apr 4;9:659.
Zhao X, Ting S, Sun G, Roy-O’Reilly M, Mobley A, Garrido J, Zheng X, Obertas L, Jung J, Kruzel M, Aronowski J. Beneficial role of neutrophils through function of lactoferrin after intracerebral hemorrhage. Stroke. 2018 May;49(5):1241-1247.
Roy-O'Reilly M, Zhu L, Atadja L, Torres G, Aronowski J, McCullough LD, Edwards NJ. Soluble CD163 in Intracerebral Hemorrhage: Biomarker for Perihematomal Edema. Ann Clin Transl Neurol. Nov 2017;4(11):793-800.
Zhao X, Ting SM, Liu CH, Sun G, Kruzel M, Roy-O’Reilly M, Aronowski JA. Neutrophil Polarization as a Therapeutic Target for Intracerebral Hemorrhage: The Role of IL-27. Nature Communications. Sep 2017;8(1):602.
Roy-O’Reilly M, Ritzel RM, Conway SE, Staff I, Fortunato G, McCullough LD. CCL11 (Eotaxin-1) Levels Predict Long-Term Functional Outcomes in Patients Following Ischemic Stroke. Transl Stroke Res. 2017 Dec;8(6):578-584.
Roy-O’Reilly M, McCullough LD. Astrocytes fuel the fire of lymphocyte toxicity after stroke. Proc Natl Acad Sci USA. Jan 2017; 114(3):425-427.
Conway, S.E., Roy-O’Reilly,M., Friedler, B., Staff, I., Fortunato, G., McCullough, L.D. Sex differences and the role of IL-10 in ischemic stroke recovery. Biology of Sex Differences. 2015; 6:17.
Roy-O’Reilly, M., DeAngelis A.R. Intersection of the genomics of cholesterol metabolism and cardiometabolic disease with reproductive health. In A. Rodriguez (Ed.), Cardiometabolic Genomic Medicine. Philadelphia, PA. Elsevier, 2015.
DeAngelis, A.M, Roy-O’Reilly, M., Rodriguez, A. (2014). Genetic alterations affecting cholesterol metabolism and human fertility. Journal of Repro. Biol. 2014:91 (5): 117.
Roy-O’Reilly, M. and McCullough, L.D. (2014). Sex differences in stroke: the contribution of coagulation. Experimental Neurology. 2014; 259:16-27.
HONORS AND AWARDS
- Globus New Investigator in Stroke Award. American Heart Association (2019)
- President’s Scholar Award. UT Health & MD Anderson (2018)
- Research Travel Award. American Physician Scientist Association (2018)
- George M. Stancel Fellowship. UT Health & MD Anderson (2017)
- Dean’s Research Scholarship. UT Health Science Center at Houston (2017)
- NIH F30 NRSA Fellowship. National Institute of Neurological Disorders and Stroke (2017)
- Berlin Junior Investigator Travel Fellowship. JCBFM (2017)
- T. C. Hsu Memorial Scholarship. UT Health & MD Anderson Cancer Center (2017)
- Hawkins Foundation Discovery Fellowship. UT Health & MD Anderson (2016)
- Graduate Oral Presentation Competition, People’s Choice Award. UT Health (2016)
- Research Council Travel Grant. University of Connecticut Health Center (2015)
- Outstanding Senior in Molecular and Cell Biology. University of Connecticut (2012)
- University Scholar Distinction. University of Connecticut (2011)
- Drotch Memorial Scholarship. University of Connecticut (2010)
- Academic Excellence Scholarship. University of Connecticut (2008 – 2012)
Roy-O’Reilly M, Mulavara A, Williams T. Spaceflight-Associated Structure/Function Alterations in the Brain and Risk to Operational Performance. NASA Aerospace Medicine Clerkship Research Day. NASA Johnson Space Center, Houston, Texas. 2019. Poster.
Roy-O’Reilly M, Ahnstedt H, Spychala M, Munshi Y, McCullough LD. Aging Exacerbates Neutrophil Pathogenicity in Ischemic Stroke. International Stroke Conference, Honolulu, Hawaii. 2019. Poster. Globus New Investigator in Stroke Award.
Roy-O’Reilly M, Ahnstedt H, McCullough LD. Age Enhances Neutrophil Pathogenicity in Ischemic Stroke. Keystone Conference on Inflammation in Health and Chronic Disease. Dublin, Ireland. 2018. Poster
Roy-O’Reilly, M. McCullough L. The importance of age and sex in post-stroke immunotherapy. MD/PhD Research Retreat. Houston, Texas. 2017. Oral presentation.
Roy-O’Reilly M, Ahnstedt H, McCullough LD. Age and Sex Influence the Neutrophil Response to Ischemic Stroke in Mice and Humans. Berlin Brain & Brain Pet. Berlin, Germany. 2017. Poster
Roy-O’Reilly M, McCullough LD. Age and Sex Influence the Neutrophil Response to Ischemic Stroke in Mice and Humans. International Stroke Conference, Houston, TX. 2017. Oral Presentation.
Roy-O’Reilly, M. McCullough L. Aged females exhibit enhanced pro-inflammatory leukocyte phenotypes. OSSD, Philadelphia, PA. 2016. Oral Presentation.
Roy-O’Reilly, M. Manwani, B. Increased P450 Aromatase Level in Post-Menopausal Women After an Acute Ischemic Stroke. International Stroke Conference, Los Angeles, CA. 2016. Talk.
Roy-O’Reilly M, Conway S, Staff I, McCullough L. The sex-specific link between eotaxin and ischemic stroke outcomes. Stanford, CA. 2015. Poster
Roy-O’Reilly M, Howe MD, Venna V, McCullough LD. Sex differences in Transforming Growth Factor-B Activated Kinase Signaling Following Experimental Stroke. American Heart Association: Scientific Sessions. Chicago, IL. 2014. Invited Poster.