Kyle Lyman, MD, PhD


  • Internship: Stanford University Hospital (2019-2020)
  • Postdoctoral fellowship: Vanderbilt University (2018-2019)
  • Medical School: Northwestern University, MD (2019)
  • Graduate School: Northwestern University, PhD in Neuroscience (2017)
  • Undergraduate: The Ohio State University, BS Mathematics (2011)



  • Epilepsy
  • Machine Learning
  • Ion channel trafficking



Hippocampal cAMP regulates HCN channel function on two time scales with differential effects on animal behavior. Lyman KA*, Han Y*, Zhou C*, Renteria I, Besing GL, Kurz JE, Chetkovich DM. Sci Transl Med. 2021 Nov 24;13(621):eabl4580 

The structure and function of TRIP8b, an auxiliary subunit of hyperpolarization-activated cyclic-nucleotide gated channels. Han Y*, Lyman KA*, Foote KM*, Chetkovich DM.Channels (Austin). 2020 Dec;14(1):110-122.

Moving Metabolism to Make Inroads in a Model of Mitochondrial Epilepsy. Lyman KA, Chetkovich DM.Epilepsy Curr. 2019 Nov-Dec;19(6):408-410.

Phosphorylation of the HCN channel auxiliary subunit TRIP8b is altered in an animal model of temporal lobe epilepsy and modulates channel function. Foote KM, Lyman KA, Han Y, Michailidis IE, Heuermann RJ, Mandikian D, Trimmer JS, Swanson GT, Chetkovich DM.J Biol Chem. 2019 Oct 25;294(43):15743-15758.

Oligodendrocyte Kir4.1 Channels Clear Out Congested K. Lyman KA, Chetkovich DM.Epilepsy Curr. 2019 Sep;19(5):339-340.

Current Opinions and Consensus for Studying Tremor in Animal Models. Kuo SH, Louis ED, Faust PL, Handforth A, Chang SY, Avlar B, Lang EJ, Pan MK, Miterko LN, Brown AM, Sillitoe RV, Anderson CJ, Pulst SM, Gallagher MJ, Lyman KA, Chetkovich DM, Clark LN, Tio M, Tan EK, Elble RJ.Cerebellum. 2019 Dec;18(6):1036-1063.

CRAFTing a New Approach to Antiepileptic Drug Discovery. Lyman KA, Chetkovich DM.Epilepsy Curr. 2019 May-Jun;19(3):182-183. d

PUMILIO1 Links Epilepsy to Spinocerebellar Ataxia. Lyman KA, Chetkovich DM.Epilepsy Curr. 2019 Mar-Apr;19(2):122-123.

Pannexin1 as a Possible Panacea for Intractable Epilepsy. Lyman KA, Chetkovich DM.Epilepsy Curr. 2018 Nov-Dec;18(6):396-397.

HCN channels in the hippocampus regulate active coping behavior. Fisher DW*, Han Y*, Lyman KA*, Heuermann RJ, Bean LA, Ybarra N, Foote KM, Dong H, Nicholson DA, Chetkovich DM.J Neurochem. 2018 Sep;146(6):753-766.

Molecular Mimicry may Underlie a Worm-Associated Epilepsy Syndrome. Lyman KA, Chetkovich DM.Epilepsy Curr. 2018 May-Jun;18(3):180-181.

Neuroinflammation Alters Integrative Properties of Rat Hippocampal Pyramidal Cells. Frigerio F, Flynn C, Han Y, Lyman K, Lugo JN, Ravizza T, Ghestem A, Pitsch J, Becker A, Anderson AE, Vezzani A, Chetkovich D, Bernard C.Mol Neurobiol. 2018 Sep;55(9):7500-7511.

Allostery between two binding sites in the ion channel subunit TRIP8b confers binding specificity to HCN channels. Lyman KA*, Han Y*, Heuermann RJ, Cheng X, Kurz JE, Lyman RE, Van Veldhoven PP, Chetkovich DM.J Biol Chem. 2017 Oct 27;292(43):17718-17730.

New Insights Into Postictal Paresis: An Epilepsy-Associated Phenomenon That may not be as Benign as Long Thought. Lyman KA, Chetkovich D.Epilepsy Curr. 2017 May-Jun;17(3):167-168.

Animal models suggest the TRIP8b-HCN interaction is a therapeutic target for major depressive disorder. Lyman KA*, Han Y*, Chetkovich DM.Expert Opin Ther Targets. 2017 Mar;21(3):235-237.

Method for Identifying Small Molecule Inhibitors of the Protein-protein Interaction Between HCN1 and TRIP8b. Han Y*, Lyman KA*, Clutter M, Schiltz GE, Ismail QA, Cheng X, Luan CH, Chetkovich DM.J Vis Exp. 2016 Nov 11;(117):54540.

Reduction of thalamic and cortical Ih by deletion of TRIP8b produces a mouse model of human absence epilepsy. Heuermann RJ, Jaramillo TC, Ying SW, Suter BA, Lyman KA, Han Y, Lewis AS, Hampton TG, Shepherd GMG, Goldstein PA, Chetkovich DM.Neurobiol Dis. 2016 Jan;85:81-92.

Chronic Granulomatous Disease: A Large, Single-center US Experience. Bortoletto P, Lyman K, Camacho A, Fricchione M, Khanolkar A, Katz BZ.Pediatr Infect Dis J. 2015 Oct;34(10):1110-4.

HTR7 Mediates Serotonergic Acute and Chronic Itch. Morita T, McClain SP, Batia LM, Pellegrino M, Wilson SR, Kienzler MA, Lyman K, Olsen AS, Wong JF, Stucky CL, Brem RB, Bautista DM.Neuron. 2015 Jul 1;87(1):124-38.

Identification of Small-Molecule Inhibitors of Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels. Han Y*, Lyman K*, Clutter M, Schiltz GE, Ismail QA, Prados DB, Luan CH, Chetkovich DM.J Biomol Screen. 2015 Oct;20(9):1124-31.

Cortical Compass: EML1 Helps Point the Way in Neuronal Migration. Lyman KA, Chetkovich DM.Epilepsy Curr. 2015 Jan-Feb;15(1):43-4.  

Reconciling the influence of task-set switching and motor inhibition processes on stop signal after-effects. Anguera JA, Lyman K, Zanto TP, Bollinger J, Gazzaley A.Front Psychol. 2013 Sep 24;4:649.

*Denotes equal contribution



  • MD Summa Cum Laude, Magna Cum Laude in Scientia Experimentali (2019)
  • Northwestern MSTP award for clinical excellence (2019)
  • Alpha Omega Alpha (2018)
  • Heller Travel Grant (2014)
  • Kurt and Rhoda Isselbacher Grant (2014)
  • Woods Hole Marine Biological Laboratory Neurobiology Course (2014)    
  • Howard Hughes Medical Institute Grant to support tuition at Woods Hole (2014)    
  • Heller Award for Excellence in the Pre-clinical Curriculum, 2013
  • Bachelor of Science in Mathematics, Magna Cum Laude (2011)



Hiking, jogging, exploring the bay