David Rogawski, MD, PhD
Education Chief Resident, 2021-2022
Medicine Internship, California Pacific Medical Center, June 2018-June 2019
MD/PhD Program, University of Michigan Medical School, July 2010-May 2018
MSc, University of Otago, New Zealand, November 2008-May 2010
BA, Williams College, September 2004-June 2008
- Drug development
- Medical education
Rogawski DS, Deng J, Li H, Miao H, Borkin D, Purohit T, Song J, Chase J, Li S, Ndoj J, Klossowski S, Kim E, Mao F, Zhou B, Ropa J, Krotoska MZ, Jin Z, Ernst P, Feng X, Huang G, Nishioka K, Kelly S, He M, Wen B, Sun D, Muntean A, Dou Y, Maillard I, Cierpicki T, Grembeck J. Discovery of first-in-class inhibitors of ASH1L histone methyltransferase with anti-leukemic activity. Nat Commun 12, 2792 (2021)
Huang H, Howard CA, Zari S, Cho HJ, Shukla S, Li H, Ndoj J, González-Alonso P, Nikolaidis C, Abbott J, Rogawski DS, Potopnyk MA, Kempinska K, Miao H, Purohit T, Henderson A, Mapp A, Sulis ML, Ferrando A, Grembecka J, Cierpicki T. Covalent inhibition of NSD1 histone methyltransferase. Nat Chem Biol. 2020 Dec;16(12):1403-1410
Rogawski DS, Vitanza NA, Gauthier AC, Ramaswamy V, Koschmann C. Integrating RNA sequencing into neuro-oncology practice. Transl Res 189, 93-104 (2017).
Horowitz S, Koepnick B, Martin R, Tymieniecki A, Winburn AA, Cooper S, Flatten J, Rogawski DS, Koropatkin NM, Hailu TT, Jain N, Koldewey P, Ahlstrom LS, Chapman MR, Sikkema AP, Skiba MA, Maloney FP, Beinlich FRM, Foldit players, University of Michigan students, Popović Z, Baker D, Khatib F, Bardwell JCA. Playing with a purpose: determining crystal structures through crowdsourcing and coursework. Nat Commun 7, 12549 (2016).
Rogawski DS, Grembecka J, and Cierpicki T. H3K36 methyltransferases as cancer drug targets: rationale and perspectives for inhibitor development. Future Med Chem 8, 1589-607 (2016).
Rogawski DS, Ndoj J, Cho HJ, Maillard I, Grembecka J, Cierpicki T. Two Loops Undergoing Concerted Dynamics Regulate the Activity of the ASH1L Histone Methyltransferase. Biochemistry 54, 5401-13 (2015).
Lee KJ, Panzera A, Rogawski D, Greene LE, Eisenberg E. Cellular prion protein (PrPC) protects neuronal cells from the effect of huntingtin aggregation. Journal of Cell Science 120, 2663-2671 (2007).
Rogawski DS, Mulinyawe SB, Thomas C, Monje M. Neurophysiological small molecule screen to target neuron-glioma interactions in pediatric high-grade gliomas. 6th Biennial Pediatric Neuro-Oncology Research Conference, June 10-12, 2021.
Grembecka J, Cierpicki T, Rogawski D, Klossowski S, Borkin, D, Zhuang J, Montgomery D, Deng J, Szewczyk M, Li H. “Ash1L inhibitors and methods of treatment therewith.” International Patent WO 2017197240 A1, Nov 16, 2017.
AWARDS AND HONORS
- Francis J. Rigney Intern of the Year Award, California Pacific Medical Center (2019)
- American Academy of Neurology Medical Student Prize for Excellence in Neurology (2018)
- Most aesthetic oral presentation at Michigan Medical Scientist Training Program Annual Retreat (2016)
- Best poster presentation at the 13th Annual Michigan Pathology Research Symposium (2014)
- William C. Grant, Jr. Prize in biology for highest excellence and greatest insights in integrating different fields within the biological sciences (2008)
- Sam Goldberg Prize for the best senior colloquium presentation in mathematics (2008)