EDUCATION
- Internship & Residency: University of Massachusetts Medical School/UMass Memorial Medical Center
- Medical School: Kyung Hee University College of Medicine, South Korea (M.D.-Ph.D.)
- Undergraduate: Korea Advanced Institute of Science and Technology (KAIST), South Korea (B.S., Summa cum laude in Chemistry)
RESEARCH INTEREST
- Parkinson’s Disease
- Biomarkers
PUBLICATIONS
- Currens L, Je G*, Church R, Daniello K, Serna F, Moen J, Han JY, Jun-O’Connell A (2022). An Interprofessional Residency Education and Utilization of the Phone-adapted Panoptic Ophthalmoscope, Neurology, Accepted
- Fang T, Je G*, Pacut P, Keyhanian K, Gao J, Ghasemi M (2022). Gene Therapy in Amyotrophic Lateral Sclerosis, Cells, 11(13), 2066
- Je G*, Arora S, Raithartha S, Barrette R, Valizadeh N, Shah U, Desai D, Deb A, Desai S (2021). Epidemiology of Parkinson’s disease in rural Gujarat, India, Neuroepidemiology. 55(3):188-95
- Je G*, Sun Y, Keyhanian K, Yaghi S, Henninger N (2021). Dorsal nucleus of the vagal nerve involvement related to QTc prolongation after acute medullary infarction, Acta Neurologica Scandinavica. 144(3):283-87
- Je G*, Kayhanian K, Ghasemi M. Stem Cell Therapy in Amyotrophic Lateral Sclerosis: An Update (2021), Neurological Research. 43(8):616-32
- Guhathakurta S, Kim J, Adams L, Basu S, Song MK, Adler E, Je G*, Fiadeiro MB, Kim YS (2021). Targeted attenuation of elevated histone marks at SNCA alleviates α-synuclein in Parkinson’s disease, EMBO Molecular Medicine. 13:e12188
- Je G*, Ghasemi M (2020). Myasthenia Gravis and Pregnancy: An Overview, World Journal of Obstetrics and Gynecology. 9(1):1-10
- Cristóvão AC, Campos FL, Je G*, Esteves M, Guhathakurta S, Yang L, Beal F, Fonseca BM, Salgado AJ, Queiroz J, Sousa N, Bernardino L, Alves G, Yoon KS and Kim YS (2020). Characterization of a Parkinson disease rat model using an improved paraquat exposure paradigm, European Journal of Neuroscience. 00:1-14
- Je G*, Guhathakurta S, Yun SP, Ko HS and Kim YS (2018). A novel extended form of alpha-synuclein 3'UTR in human brain, Molecular brain. 11(1):29
- Je G*, Croop B, Basu S, Han KY and Kim YS (2017). Endogenous α-SYN protein analysis from human brain tissues using single-molecule pull-down assay, Analytical Chemistry. 89 (24), 13044–48
- Je G*, Kim YS (2017). Mitochondrial ROS-mediated post-transcriptional regulation of α-synuclein through miR-7 and miR-153, Neuroscience letters. 60, 132-36
- Rocha SM, Saraiva T, Cristóvão AC, Ferreira R, Santos T, Esteves M, Saraiva C, Je G*, Cortes L, Valero J, Alves G, Klibanov A, Kim YS, Bernardino L (2016). Histamine induces microglia activation and dopaminergic neuronal toxicity via H1 receptor activation. Journal of Neuroinflammation. 13, 137
- Yoo SD, Park JS, Yun DH, Kim HS, Kim SK, Kim DH, Chon J, Je G*, Kim YS, Chung JH, Chung SJ, Yeo JA (2016). Polymorphism of Nitric Oxide Synthase 1 Affects the Clinical Phenotypes of Ischemic Stroke in Korean Population. Annals of Rehabilitation Medicine. 40, 102-10
- Basu S, Je G*, Kim YS (2015). Transcriptional mutagenesis by 8-oxodG in α-synuclein aggregation and the pathogenesis of Parkinson's disease. Experimental & Molecular Medicine. 47, e179
- Campos FL, Carvalho MM, Cristovão AC, Je G*, Baltazar G, Salgado AJ, Kim YS, Sousa N (2013). Rodent models of Parkinson's disease: beyond the motor symptomatology. Frontiers in Behavioral Neuroscience. 7, 175
- Cristóvão AC, Barata J, Je G*, Kim YS (2013). PKC delta mediates paraquat-induced Nox1 expression in dopaminergic neurons. Biochemical and Biophysical Research Communications. 437, 380-85
- Cristóvão AC, Guhathakurta S, Bok E, Je G*, Yoo SD, Choi DH, Kim YS (2012). NADPH oxidase 1 mediates α-synucleinopathy in Parkinson's disease. Journal of Neuroscience. 32, 14465-77
ABSTRACTS/PRESENTATIONS
- Currents L, Je G*, Church R, De La Serna F, Moen J, Han JY, Daniello K, Jun-O’Connell A. An interprofessional residency education and utilization of the phone-adapted panoptic ophthalmoscope. American Academy of Neurology (AAN) 2022, Seattle, WA
- Je G*, Sun Y, Keyhanian K, Henninger N. QTc prolongation in acute medullary infarction maps to the dorsal vagal nucleus. International Stroke Conference (ISC) 2021, Virtual meeting
- Je G*, Sun Y, Keyhanian K, Henninger N. Anatomical substrate of QTc-prolongation in acute medullary infarction, American Neurological Association (ANA) 2020, Virtual meeting
- Je G*, Guhathakurta S, Bok E, Basu S, Kim YS. Pum2-dependent translational regulation of alpha-synuclein mRNA on the mitochondrial outer surface, International Conference on Alzheimer’s & Parkinson’s Disease (AD/PD) 2019, Lisbon, Portugal
- Guhathakurta S, Adler E, Basu S, Je G*, Adams L, Kim YS. Regulation of α-synuclein expression reveals a key role of histone post-translational modifications in Parkinson’s disease, International Conference on Alzheimer’s & Parkinson’s Disease (AD/PD) 2019, Lisbon, Portugal
- Basu S, Guhathakurta S, Je G*, Bok E, Mclean PJ, Dickson DW, Kim YS. Implication of 8-oxodG mediated transcriptional mutagenesis of alpha-synuclein in the pathogenesis of sporadic Parkinson’s disease, International Conference on Alzheimer’s & Parkinson’s Disease (AD/PD) 2019, Lisbon, Portugal
- Guhathakurta S, Adler E, Basu S, Je G*, Adams L, Kim YS. Regulation of α-synuclein expression in Parkinson’s disease by locus-specific epigenetic remodeling of SNCA, Society for Neuroscience (SFN) 2018, San Diego, CA
- Je G*, Croop B, Han KY, Kim YS. Single-molecule pull-down assay of alpha-synuclein in dopaminergic neurons of postmortem brain tissue, Society for Neuroscience (SFN) 2017, Washington D.C., DC
- Je G*, Guhathakurta S, Bok E, Basu S, Cristóvão AC, Kim YS. Pum2-dependent translational regulation of alpha-synuclein mRNA on mitochondrial outer surface, Society for Neuroscience (SFN) 2017, Washington D.C., DC
- Basu S, Guhathakurta S, Goldblatt G, Tatulian S, Das S, Bok E, Je G*, Cristóvão AC, Kim YS. Implication of 8-oxodG-mediated Transcriptional Mutagenesis in sporadic Parkinson’s disease, Society for Neuroscience (SFN) 2016, San Diego, CA
- Je G*, Guhathakurta S, Basu S, Bok E, Cristóvão AC, Kim YS. Pum2-mediated translational regulation of alpha-synuclein mRNA in neurites and cross talk with mitochondria, Society for Neuroscience (SFN) 2015, Chicago, IL
- Guhathakurta S, Basu S, Bok E, Je G*, Kim YS. De-repression of TET1 by oxidative stress regulates alpha-synuclein expression in dopaminergic neurons, Society for Neuroscience (SFN) 2015, Chicago, IL
- Basu S, Guhathakurta S, Bok E, Je G*, Cristóvão AC, Kim YS. Implication of 8-oxodG-mediated Transcriptional Mutagenesis in sporadic Parkinson’s disease, Society for Neuroscience (SFN) 2015, Chicago, IL
- Je G*, Cristóvão AC, Guhathakurta S, Bok e, Looger L, Belousov V, Kim YS. Mitochondrial oxidative stress induces alpha-synuclein translation in neurites of dopaminergic neurons, Society for Neuroscience (SFN) 2013, San Diego, CA
- Guhathakurta S, Je G*, Bok E, Cristóvão AC, Kim YS. TET1 and H3K27me3 mediated epigenetic regulation of alpha-synuclein in Parkinson's Disease, Society for Neuroscience (SFN) 2013, San Diego, CA
- Cristóvão AC, Guhathakurta S, Bok E, Je G*, Choi DH, Kim YS. NOX1, a novel player in alpha-synucleinopathy in Parkinson’s Disease, Gordon Research Conference 2012, Waterville Valley, NH
AWARDS AND HONORS
- AAN Resident Scholarship to the Annual Meeting, 2022
- Neurology Chief Resident, 2021-2022
- MS Mentorship Forum Program Scholarship, Consortium of Multiple Sclerosis Centers, 2021
- President’s Award, Korean Society for Biochemistry and Molecular Biology, 2016
- National Scholarship for M.D.-Ph.D. students, Brain Korea 21 Program, 2009-2016
- Summa cum laude, Korea Advanced Institute of Science and Technology (KAIST), 2009
- National Scholarship for Science and Engineering, Korea Student Aid Foundation 2005-2009
