Esther Nie, MD, PhD

EDUCATION

  • Residency: Stanford
  • Internship: Cedars-Sinai
  • Medical School: UCLA MSTP
  • Undergraduate: Yale


INTERESTS (clinical/research)

  • Enhancing repair and regeneration after brain injury
  • Neurologic presentations in BMT, CART, and BITE therapy patients
  • Young adult neurorehabilitation
  • Biotechnology and novel CNS diagnostics/therapeutics


ARTICLES

Nie EH, Ahmadian SS, Bharadwaj SN, Acosta L, Threlkeld ZD, Frank MJ, Scott BW, Miklos DB, Monje MM, Vogel H. Multifocal demyelinating leukoencephalopathy and oligodendroglial lineage cell loss with immune effector cell-associated neurotoxicity syndrome (ICANS) following CD-19 CAR T-cell therapy for mantle cell lymphoma. J Neuropathol Exp Neurol. 2023: nlac 121 doi: 10.1093.   

Rogawski DS, Nirschl JJ, McDonald J, Nie EH, Schwartz NU, Vogel H, Scott BJ, Gold CA, Kipp LB. A rare neuromyelitis optica mimic: Primary CNS histiocytic sarcoma. Mult Scler. 2022 Sep;28(10):1651-1654.   

Majzner RG and Ramakrishna S, Yeom K, Patel S, Chinnasamy H, Schultz L, Richards R, Barsan V, Zina Good Z,  Mochizuki A, Mahdi J, Reschke A, Geraghty A, Toland AMS, Chau I,  Nie EH, Rotiroti MC, Mount C, Baggott C, Mavroukakis S, Egeler E, Moon J, Erickson C, Green S, Tamaresis JS, Kunicki M, Fujimoto M, Ehlinger Z, Reynolds W, Kurra S, Warren KE, Prabhu S, Vogel H, Rasmussen L, Cornell TT, Partap S,  Fisher P, Campen C, Grant G, Sahaf B, Davis KL, Feldman SA, Mackall CL, and Monje M. GD2-CAR T-cell therapy for H3K27M-mutated diffuse midline gliomas. Nature. 2022: 603: 934-41. 

Carmichael ST, Kathirvelu B, Schweppe CA, Nie EH. Molecular, cellular, and functional events in axonal sprouting after stroke. Exp Neurol. 2016: 16: 30029-2.

Li S*, Nie EH*, Yin Y, Benowitz LI, Tung S, Vinters HV, Bahjat FR, Stenzel-Poore MP, Kawaguchi R, Coppola G, Carmichael ST. GDF10 is a signal for axonal sprouting and functional recovery after stroke.  Nat Neurosci. 2015: 12: 1737-45.

Greten-Harrison B, Polydoro M, Morimoto-Tomita M, Diao L, Williams AM, Nie EH, Makani S, Tian N, Castillo PE, Buchman VL, Chandra SS. αβγ-Synuclein triple knockout mice reveal age-dependent neuronal dysfunction. Proc Natl Acad Sci. 2010: 107: 19573-8.


SELECT ABSTRACTS/PRESENTATIONS

Nie EH, Lafeuille P, Diamond S, Aptekar J, Agarwal V. Cooccurrence patterns of CRS and ICANS in patients undergoing autologous CD19-targeted CAR T-cell treatments. Presented at the 5th EBMT-European Hematology Association CAR T-cell Meeting, Rotterdam, Netherlands, Feb 2023.   

Nie EH, Ahmadian SS, Bharadwaj SN, Acosta-Alvarez L, Threlkeld ZD, Frank MJ, Miklos DB, Monje M, Scott, BJ, Vogel H. Multifocal demyelinating leukoencephalopathy and oligodendrocyte lineage cell loss with Immune Effector Cell-associated Neurotoxicity Syndrome (ICANS) in CD19 CART cell therapy for Mantle Cell Lymphoma. Presented at the 98th Annual Meeting of American Association of Neuropathologists, Bonita Springs, FL, June 2022.  

Young R, Nie EH, Mukarram F, Szeder V, Duckwiler G. Comprehensive Stroke Measures in an Academic versus Private Practice Setting. 5th Annual World Live Neurovascular Conference, Los Angeles, CA, 2017.

Nie EH, Coppola G, Kawaguchi R, Carmichael S.T. Candidate testing of axonal sprouting genes in a cortical circuit induced by limb overuse after stroke. Presented at Genome Editing Congress, Oxford, UK, March 2016 .

Wang Q, Nie EH, Carmichael ST. Activity-dependent molecular programs for optic nerve regeneration. 45th Annual meeting of the Society of Neuroscience, San Diego, CA, 2016.

Nie EH, Kawaguchi R, Coppola G, Carmichael ST. Mechanisms of axonal sprouting in a cortical circuit induced by limb overuse after stroke.  44th Annual meeting of the Society of Neuroscience, Chicago, IL, 2015.

Schweppe CA, Nie EH, Li S, Carmichael ST. Stroke transcriptome-driven analysis of axonal outgrowth mechanisms. 44th Annual meeting of the Society of Neuroscience, Chicago, IL, 2015.

Nie EH, Coppola G, Carmichael ST. Activity-dependent formation of a novel premotor connection after ischemic stroke. 9th World Congress International Brain Research Organization, Rio de Janeiro, Brazil, 2015.

Nie EH, Carmichael ST. Activity-dependent mechanisms of cortical reorganization during limb-overuse after stroke. Annual meeting of the American Society of Neurorehabilitation and 43rd Annual meeting of the Society for Neuroscience, San Diego, CA, 2013.

Nie EH, Carmichael ST. Identifying activity-dependent cortical circuits in stroke recovery. 42nd Annual meeting of the Society of Neuroscience, New Orleans, LA, 2012.


AWARDS AND HONORS

American Academy of Neurology (AAN) Medical Student Prize for Excellence in Neurology  (2018)

Co-awarded 1st place prize Radiology Award for neurovascular research presentation (2017)

Eva Kavan Prize in basic brain research, awarded to one graduating neuroscience PhD thesis  (2016)

Ruth L. Kirschstein National Research Service Award (NRSA), NINDS F31 (2013-2015)

Predoctoral Research Fellowship, American Heart Association (2013-2015)

Training Program in Neural Repair NIH T32 grant recipient  (2012-2013)

Distinction in the Major: Molecular Biophysics and Biochemistry (2009)

Yale University Sheffield Scientific Scholarship (2007-2009)


HOBBIES

Nature and street photography

Marinating in the creative process (ie in design, gastronomy, essaying/storytelling)

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