Select Multiple Sclerosis and Neuroimmunology Publications

Les Dorfman, MD

Neurocognitive impairment in adults with moyamoya disease without stroke.
Karzmark P, Zeifert PD, Bell-Stephens TE, Steinberg GK, Dorfman LJ. Neurosurgery. 2012; 70 (3): 634-8

Neuroradiologic correlates of cognitive impairment in adult Moyamoya disease.
Mogensen MA, Karzmark P, Zeifert PD, Rosenberg J, Marks M, Steinberg GK, Dorfman LJ. AJNR Am J Neuroradiol. 2012; 33 (4): 721-5

 

Lawrence Steinman, MD

Identification of Naturally Occurring Fatty Acids of the Myelin Sheath That Resolve
Neuroinflammation. Ho P,  Kanter J, Johnson AM, Srinagesh H, Chang E, Purdy TM, van Haren KP, Wikoff, WR, Kind T, Khademi M, Matloff L, Narayana S, Hur EM, Lindstrom TM, He Z, Fiehn Ok Olsson T, Han X Han MH, Steinman L and Robinson WH. Sci Transl Med 4(137):137ra73, 2012

Janus-Like Opposing Roles of CD47 in Autoimmune Brain Inflammation.
Han MH, Lundgren DH, Jaiswal S, Chao M, Graham KL, Garris CS, Axtell RC, Ho PP, Lock CB, Woodward JI, Brownell SE, Zoudilova M, Hunt JFV, Branzini S, Butcher E, Raine CS, Sobel RA, Han DK, Weissman I, and Steinman L. J Exp Med, 209:1325-1334, 2012

Peroxisome proliferator-activated receptors (PPAR)-α and -γ regulate IFNγ and IL-17A production by human T cells in a sex-specific way.
Zhang MA , Rego D, Moshkova M, Kebir  H, Chruscinski  A, Nguyen HK , Akkermann R, Stanczyk FZ, Prat A, Steinman L, Dunn S. Proc Natl Acad Sci 109(24):9505-9510, 2012.

Unexpected Therapeutic Benefit from Peripheral Administration of Amyloid-β in Th1- and Th17-Versions of Experimental Autoimmune Encephalomyelitis. 
Grant JL, Bou Ghosn EE , Axtell RC, Herges K, Kuipers HF, Woodling NS, Andreasson K, Herzenberg LA, Herzenberg LA, Lawrence Steinman L.  Sci Transl Med, 4: 145ra105, 2012.

The Discovery of Natalizumab, A Potent Therapeutic for Multiple Sclerosis.
Steinman L.  Journal of Cell Biology 199(3):413-6, 2012.

Piet Mondrian’s trees and the evolution in understanding multiple sclerosis, Charcot Prize Lecture 2011 
Steinman L, Axtell RC, Barbieri D, Bhat R, Brownell S, de Jong BA, Dunn SE, Grant JL, Han MH, Ho P, Kuipers HF, Kurnellas MP, Ousman SS, and  Rothbard J. Multiple Sclerosis Journal 19:5-14, 2013.

Weighing in on Autoimmune disease: ‘Hub and Spoke’ T cell Traffic in Autoimmunity.
Steinman L.  Nature Medicine, 19:139-141, 2013.

Amyloid fibrils composed of hexameric peptides attenuate neuroinflammation.
Kurnellas MP, Adams CM, Sobel RA, Steinman L, Rothbard JB. Sci Transl Med. 2013; 5 (179): 179ra42

 

Jeffrey Dunn, MD

Defining the Neuroimmunology/Multiple Sclerosis Subspecialty: Surveys of Fellowship Training in the Unites States.
Longbrake, E., Obeidat, A., Dunn, J., Sicotte, N., Hua, L. Lippincott Williams & Wilkins 2020. Web of Science # 000536058001053

Advocacy, Dissemination and Implementation Strategies for an International Standardized MRI Protocol for Diagnosis and Follow-Up of patients with Multiple Sclerosis.
Saslow, L., Li, D., Halper, J., Banwell, B., Barkhof, F., Barlow, L., Costello, K., Damiri, B., Dunn, J., Giri, S., Maes, M., Morrow, S., Newsome, S., Oh, J., Friedemann, P., Quarterman, P., Reich, D., Shewchuk, J., Shinohara, R., Van Hecke, W., Van dee Ven, K., Wallin, M., Wolinsky, J., Traboulsee, T. Int J MS Care. 2020; 22:226-232.

Consensus Curriculum for Fellowship Training in Multiple Sclerosis and Neuroimmunology.
Le H. Hua, Ahmed Obeidat, Lilyana Amezcua, Jeffrey A. Cohen, Kathleen Costello, Jeffrey Dunn, Jeffrey Gelfand, Myla Goldman, Sarah Hopkins, Douglas Jeffery, Stephen Krieger, Scott Newsome, Suma Shah, Nancy Sicotte, Vijayshree Yadav, Erin Longbrake. Neurol Clin Pract Jan 2021, 10.1212/CPJ.0000000000001040;  DOI: 10.1212/CPJ.0000000000001040

Repopulation of T, B and NK cells following alemtuzumab treatment in relapsing-remitting Multiple Sclerosis.
Gilmore, W., Lund, B., Li, P., Levy, A., Kelland, E., Akbari, O., Groshen, S., Yong, S., Pelletier, D., Weiner, L., Javed, A., Dunn, J., Traboulsee, T. Journal of Neuroinflammation 2020; 17 (1): 189

Disease Modifying Therapies for non-relapsing Multiple Sclerosis: Absence of evidence does not constitute evidence of absence.
Dunn, J. Neurol Clin Pract. December 2013; 3 (6): 515-518

Mobility Concerns in Multiple Sclerosis- Studies and Surveys on US patient populations of relevance to nurses.
Lee, J., Dunn J. US Neurology; 2013; 9(1): 17-23

Dalfampridine: A brief review of its Mechanism of Action and Efficacy as a treatment to improve walking in patients with Multiple Sclerosis.
Dunn J, Blight A. Current Research Medical Opinion. 2011; 27 (7): 1415-1423

Protective Effect of elastase inhibitor in a neuromyelitis optica-like disease driven by a peptide of myelin olidodendrocyte glycoprotein.
Herges K, DeJong BA, Kolkowitz I, Dunn C, Mandelbaum G, Maini A, Han M, Killestein J, Polman C, Goodyear A, Dunn J, Steinman L, Axtell RC. Multiple Sclerosis. 2012; 18 (4): 398-408

The impact of mobility impairment on the burden of caregiving in individuals with multiple sclerosis
Dunn, J., Expert Rev. Pharmacoeconomics Outcomes Res.. 2010; 10 (4): 433-440

Analysis of B Cell Subsets in Multiple Sclerosis Patients on Immunomodulatory Therapy Reveals Modulation of CD19+CD24hiCD38hi Cells With Implications for the Diagnosis and Monitoring of MS
Schubert R., Goodyear A., Abraham P., Dunn C., Steinman L.; Senior authors: Dunn J. and Axtell R.: American Academy of Neurology Annual meeting abstract # P03.224;  San Diego, CA: 19 March 2013

MRI Characteristics of CNS Demyelinating Disease in Ethnic Indian Patients.
Hua, Le H., Le, Jong-mi, Dunn J.; Consortium of Multiple Sclerosis Centers CMSC Annual Conference; Montreal, Canada: 2011

CMV Optic Neuritis with Extensive Tracking along the Visual Pathway
Pershing S, Dunn J, Khan A, Liao JY, J Neuro-Ophthalmology. 2009; 29 (3): 223-226

Glatiramer Acetate after Induction Therapy with Mitoxantrone in Relapsing Multiple Sclerosis
Vollmer T, Panitch H, Bar-Or A, Dunn J, Freedman MS, Gazda SK,Campagnolo D, Deutsch F, Arnold D, Multiple Sclerosis. 2008 Apr 18

Glatiramer Acetate after Mitoxantrone Induction improves MRI markers of lesion volume and permanent tissue injury in MS
Arnold D., Campagnolo D., Panitch H., Bar-Or A., Dunn J, Freedman M., Gazda S.K., Vollmer T., J Neurol. 2008: 255 1473-1478

 

May Han, MD

Identification of naturally occurring fatty acids of the myelin sheath that resolve neuroinflammation.
Ho PP, Kanter JL, Johnson AM, Srinagesh HK, Chang EJ, Purdy TM, van Haren K, Wikoff WR, Kind T, Khademi M, Matloff LY, Narayana S, Hur EM, Lindstrom TM, He Z, Fiehn O, Olsson T, Han X, Han MH, Steinman L, Robinson WH. Sci Transl Med. 2012; 4 (137): 137ra73

Janus-like opposing roles of CD47 in autoimmune brain inflammation in humans and mice.
Han MH, Lundgren DH, Jaiswal S, Chao M, Graham KL, Garris CS, Axtell RC, Ho PP, Lock CB, Woodard JI, Brownell SE, Zoudilova M, Hunt JF, Baranzini SE, Butcher EC, Raine CS, Sobel RA, Han DK, Weissman I, Steinman L. J Exp Med. 2012; 209 (7): 1325-34

Protective effect of an elastase inhibitor in a neuromyelitis optica-like disease driven by a peptide of myelin oligodendroglial glycoprotein.
Herges K, de Jong BA, Kolkowitz I, Dunn C, Mandelbaum G, Ko RM, Maini A, Han MH, Killestein J, Polman C, Goodyear AL, Dunn J, Steinman L, Axtell RC. Mult Scler. 2012; 18 (4): 398-408

T helper type 1 and 17 cells determine efficacy of interferon-beta in multiple sclerosis and experimental encephalomyelitis.
Axtell RC, de Jong BA, Boniface K, van der Voort LF, Bhat R, De Sarno P, Naves R, Han M, Zhong F, Castellanos JG, Mair R, Christakos A, Kolkowitz I, Katz L, Killestein J, Polman CH, de Waal Malefyt R, Steinman L, Raman C. Nat Med. 2010; 16 (4): 406-12

 

Jong-Mi Lee, NP

Mobility Concerns in Multiple Sclerosis- Studies and Surveys on US patient populations of relevance to nurses.
Lee, J., Dunn J. US Neurology; 2013; 9(1): 17-23

 

Raymond A. Sobel, MD

Amyloid fibrils composed of hexameric peptides attenuate neuroinflammation.
Kurnellas MP, Adams CM, Sobel RA, Steinman L, Rothbard JB. Sci Transl Med. 2013; 5 (179): 179ra42

A transgenic model of central nervous system autoimmunity mediated by CD4+ and CD8+ T and B cells.
Anderson AC, Chandwaskar R, Lee DH, Sullivan JM, Solomon A, Rodriguez-Manzanet R, Greve B, Sobel RA, Kuchroo VK. J Immunol. 2012; 188 (5): 2084-92

Apparent expression of varicella-zoster virus proteins in latency resulting from reactivity of murine and rabbit antibodies with human blood group a determinants in sensory neurons.
Zerboni L, Sobel RA, Lai M, Triglia R, Steain M, Abendroth A, Arvin A. J Virol. 2012; 86 (1): 578-83

Bat3 promotes T cell responses and autoimmunity by repressing Tim-3–mediated cell death and exhaustion.
Rangachari M, Zhu C, Sakuishi K, Xiao S, Karman J, Chen A, Angin M, Wakeham A, Greenfield EA, Sobel RA, Okada H, McKinnon PJ, Mak TW, Addo MM, Anderson AC, Kuchroo VK. Nat Med. 2012; 18 (9): 1394-400

Chaperone activity of small heat shock proteins underlies therapeutic efficacy in experimental autoimmune encephalomyelitis.
Kurnellas MP, Brownell SE, Su L, Malkovskiy AV, Rajadas J, Dolganov G, Chopra S, Schoolnik GK, Sobel RA, Webster J, Ousman SS, Becker RA, Steinman L, Rothbard JB. J Biol Chem. 2012; 287 (43): 36423-34

Defect in regulatory B-cell function and development of systemic autoimmunity in T-cell Ig mucin 1 (Tim-1) mucin domain-mutant mice.
Xiao S, Brooks CR, Zhu C, Wu C, Sweere JM, Petecka S, Yeste A, Quintana FJ, Ichimura T, Sobel RA, Bonventre JV, Kuchroo VK. Proc Natl Acad Sci U S A. 2012; 109 (30): 12105-10

Janus-like opposing roles of CD47 in autoimmune brain inflammation in humans and mice.
Han MH, Lundgren DH, Jaiswal S, Chao M, Graham KL, Garris CS, Axtell RC, Ho PP, Lock CB, Woodard JI, Brownell SE, Zoudilova M, Hunt JF, Baranzini SE, Butcher EC, Raine CS, Sobel RA, Han DK, Weissman I, Steinman L. J Exp Med. 2012; 209 (7): 1325-34

Laquinimod, a quinoline-3-carboxamide, induces type II myeloid cells that modulate central nervous system autoimmunity.
Schulze-Topphoff U, Shetty A, Varrin-Doyer M, Molnarfi N, Sagan SA, Sobel RA, Nelson PA, Zamvil SS. PLoS One. 2012; 7 (3): e33797

Aberrant mitochondrial fission in neurons induced by protein kinase C{delta} under oxidative stress conditions in vivo.
Qi X, Disatnik MH, Shen N, Sobel RA, Mochly-Rosen D. Mol Biol Cell. 2011; 22 (2): 256-65

Th17 cells induce ectopic lymphoid follicles in central nervous system tissue inflammation.
Peters A, Pitcher LA, Sullivan JM, Mitsdoerffer M, Acton SE, Franz B, Wucherpfennig K, Turley S, Carroll MC, Sobel RA, Bettelli E, Kuchroo VK. Immunity. 2011; 35 (6): 986-96

Tyrosine kinase inhibitors ameliorate autoimmune encephalomyelitis in a mouse model of multiple sclerosis.
Crespo O, Kang SC, Daneman R, Lindstrom TM, Ho PP, Sobel RA, Steinman L, Robinson WH. J Clin Immunol. 2011; 31 (6): 1010-20

Enhanced expression of mitochondrial superoxide dismutase leads to prolonged in vivo cell cycle progression and up-regulation of mitochondrial thioredoxin.
Kim A, Joseph S, Khan A, Epstein CJ, Sobel R, Huang TT. Free Radic Biol Med. 2010; 48 (11): 1501-12

Expression of varicella-zoster virus immediate-early regulatory protein IE63 in neurons of latently infected human sensory ganglia.
Zerboni L, Sobel RA, Ramachandran V, Rajamani J, Ruyechan W, Abendroth A, Arvin A. J Virol. 2010; 84 (7): 3421-30

Peroxisome proliferator-activated receptor delta limits the expansion of pathogenic Th cells during central nervous system autoimmunity.
Dunn SE, Bhat R, Straus DS, Sobel RA, Axtell R, Johnson A, Nguyen K, Mukundan L, Moshkova M, Dugas JC, Chawla A, Steinman L. J Exp Med. 2010; 207 (8): 1599-608

Tim-3/galectin-9 pathway: regulation of Th1 immunity through promotion of CD11b+Ly-6G+ myeloid cells.
Dardalhon V, Anderson AC, Karman J, Apetoh L, Chandwaskar R, Lee DH, Cornejo M, Nishi N, Yamauchi A, Quintana FJ, Sobel RA, Hirashima M, Kuchroo VK. J Immunol. 2010; 185 (3): 1383-92

Blocking angiotensin-converting enzyme induces potent regulatory T cells and modulates TH1- and TH17-mediated autoimmunity.
Platten M, Youssef S, Hur EM, Ho PP, Han MH, Lanz TV, Phillips LK, Goldstein MJ, Bhat R, Raine CS, Sobel RA, Steinman L. Proc Natl Acad Sci U S A. 2009; 106 (35): 14948-53

 

Y. Joyce Liao, MD, PhD

Plasticity and stability of the visual system in human a chiasma
Hoffman MB, Kaule FR, Levin N, Masuda Y, Kimar N, Gottlob I, Horiguchi H, Dougherty RF, Stadler J, Wolynski B, Speck O, Kanowski M, Liao YJ, Wandell BA, Dumoulin SO. Neuron. 2012

Functional rescue of experimental ischemic optic neuropathy with αB-crystallin.
Pangratz-Fuehrer S, Kaur K, Ousman SS, Steinman L, Liao YJ. Eye (Lond). 2011; 25 (6): 809-17

Junctional visual field loss in a case of Wyburn-Mason syndrome.
Liu A, Chen YW, Chang S, Liao YJ. J Neuroophthalmol. 2012; 32 (1): 42-4

The immunopathology of giant cell arteritis: diagnostic and therapeutic implications.
Weyand CM, Liao YJ, Goronzy JJ. J Neuroophthalmol. 2012; 32 (3): 259-65

Dorsolateral midbrain MRI abnormalities and ocular motor deficits following cytarabine-based chemotherapy for acute myelogenous leukemia.
Doan T, Lacayo N, Fisher PG, Liao YJ. J Neuroophthalmol. 2011; 31 (1): 52-3

Giant cell arteritis: immune and vascular aging as disease risk factors.
Mohan SV, Liao YJ, Kim JW, Goronzy JJ, Weyand CM. Arthritis Res Ther. 2011; 13 (4): 231

Congenital achiasma and see-saw nystagmus in VACTERL syndrome.
Prakash S, Dumoulin SO, Fischbein N, Wandell BA, Liao YJ. J Neuroophthalmol. 2010; 30 (1): 45-8

 

Keith P. Van Haren, MD

Case Report of Subdural Hematoma in a Patient With Sturge-Weber Syndrome and Literature Review: Questions and Implications for Therapy
JOURNAL OF CHILD NEUROLOGY
Lopez J., Yeom K. W., Comi A., Van Haren K. 2013; 28 (5): 672-675

Identification of Naturally Occurring Fatty Acids of the Myelin Sheath That Resolve Neuroinflammation
SCIENCE TRANSLATIONAL MEDICINE
Ho P. P., Kanter J. L., Johnson A. M., Srinagesh H. K., Chang E., Purdy T. M., Van Haren K., Wikoff W. R., Kind T., Khademi M., Matloff L. Y., Narayana S., Hur E. M., Lindstrom T. M., He Z., Fiehn O., Olsson T., Han X., Han M. H., Steinman L., Robinson W. H. 2012; 4 (137)

Therapeutic Advances in Pediatric Multiple Sclerosis.
The Journal of pediatrics Van Haren K., Waubant E. 2013 Multiple Sclerosis Journal; 19 (13): 1726-1733

Serum autoantibodies to myelin peptides distinguish acute disseminated encephalomyelitis from relapsing- remitting multiple sclerosis.
Multiple sclerosis (Houndmills, Basingstoke, England) Van Haren K., Tomooka B. H., Kidd B. A., Banwell B., Bar-Or A., Chitnis T., Tenembaum S. N., Pohl D., Rostasy K., Dale R. C., O'Connor K. C., Hafler D. A., Steinman L., Robinson W. H. 2013